| ACLARIS THERAPEUTICS INC | COM | $49.4M | 0.7% | 9,345,000 SH | New |
| ALIGOS THERAPEUTICS INC | COM NEW | $2.6M | 0.0%Prev: 0.1% | 444,110 SH | Decreased |
| ALKERMES PLC | SHS | $209.6M | 3.1% | 4,000,000 SH | New |
| ALNYLAM PHARMACEUTICALS INC | COM | $248.3M | 3.6% | 825,000 SH | New |
| ALTIMMUNE INC | COM NEW | $58.5M | 0.9% | 19,250,000 SH | New |
| ALUMIS INC | COM | $178.6M | 2.6% | 6,348,558 SH | New |
| ATAIBECKLEY INC | COM SHS | $76.0M | 1.1% | 14,417,442 SH | New |
| AVALO THERAPEUTICS INC | COM NEW | $66.7M | 1.0%Prev: 0.1% | 3,610,000 SH | Increased+3,042,897 SH |
| AXSOME THERAPEUTICS INC. | COM | $171.3M | 2.5% | 700,000 SH | New |
| BEAM THERAPEUTICS INC | COM | $34.3M | 0.5% | 1,000,000 SH | New |
| BICARA THERAPEUTICS INC | COM | $121.7M | 1.8%Prev: 0.7% | 4,100,000 SH | Increased+1,673,343 SH |
| BIOMARIN PHARMACEUTICAL INC | COM | $189.3M | 2.8% | 3,307,481 SH | New |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | $109.4M | 1.6%Prev: 1.3% | 2,939,151 SH | Increased+939,151 SH |
| CENTURY THERAPEUTICS INC | COM | $23.2M | 0.3% | 9,462,645 SH | New |
| COGENT BIOSCIENCES INC | COM | $77.4M | 1.1% | 2,000,000 SH | New |
| COMPASS PATHWAYS PLC | SPONSORED ADS | $172.1M | 2.5%Prev: 0.8% | 12,161,496 SH | Increased+3,330,489 SH |
| CONTEXT THERAPEUTICS INC | COM | $4.1M | 0.1%Prev: 0.2% | 7,419,355 SH | Decreased |
| CORMEDIX INC | COM | $49.3M | 0.7% | 6,274,076 SH | New |
| CORVUS PHARMACEUTICALS INC | COM | $37.2M | 0.5% | 2,491,939 SH | New |
| CYTOKINETICS INC | COM NEW | $59.6M | 0.9%Prev: 3.9% | 700,000 SH | Decreased-2,950,000 SH |
| DEFINIUM THERAPEUTICS INC | COM SHS | $129.4M | 1.9% | 2,750,000 SH | New |
| DYNE THERAPEUTICS INC | COM | $33.3M | 0.5% | 1,500,000 SH | New |
| ENANTA PHARMACEUTICALS INC | COM | $21.1M | 0.3% | 1,444,167 SH | New |
| ENLIVEN THERAPEUTICS INC | COM | $11.4M | 0.2% | 225,000 SH | New |
| GENEDX HOLDINGS CORP | COM CL A | $48.1M | 0.7% | 700,000 SH | New |
| GENERATE BIOMEDICINES INC | COM SHS | $22.5M | 0.3% | 1,333,815 SH | New |
| GENMAB A/S | SPONSORED ADS | $237.6M | 3.5% | 8,650,000 SH | New |
| GH RESEARCH PLC | ORDINARY SHARES | $89.6M | 1.3%Prev: 0.8% | 3,333,334 SH | Increased+1,333,334 SH |
| GRAIL INC | COM | $125.3M | 1.8% | 1,834,944 SH | New |
| GUARDANT HEALTH INC | COM | $509.1M | 7.4%Prev: 7.1% | 3,393,312 SH | Increased-856,688 SH |
| HARROW INC | COM | $41.2M | 0.6% | 969,000 SH | New |
| HEMAB THERAPEUTICS HLDGS INC | COM SHS | $132.3M | 1.9% | 3,602,093 SH | New |
| IMMIX BIOPHARMA INC | COM | $28.6M | 0.4% | 2,775,000 SH | New |
| IMMUNOCORE HLDGS PLC | ADS | $9.9M | 0.1%Prev: 1.8% | 311,218 SH | Decreased-1,488,782 SH |
| IMMUNOVANT INC | COM | $359.9M | 5.2%Prev: 4.9% | 9,341,151 SH | Increased-158,849 SH |
| INVENTIVA SA | ADS | $3.0M | 0.0% | 800,000 SH | New |
| IONIS PHARMACEUTICALS INC | COM | $174.4M | 2.5%Prev: 6.2% | 2,200,000 SH | Decreased-2,691,544 SH |
| KAILERA THERAPEUTICS INC | COMMON STOCK | $15.4M | 0.2% | 700,000 SH | New |
| KARDIGAN INC | COM | $14.3M | 0.2% | 600,000 SH | New |
| KURA ONCOLOGY INC | COM | $21.7M | 0.3% | 1,978,565 SH | New |
| LB PHARMACEUTICALS INC | COM SHS | $108.8M | 1.6% | 3,352,804 SH | New |
| MANNKIND CORP | COM NEW | $25.6M | 0.4% | 6,000,000 SH | New |
| MAZE THERAPEUTICS INC | COM | $111.4M | 1.6%Prev: 1.6% | 3,732,569 SH | Increased-216,341 SH |
| MBX BIOSCIENCES INC | COM | $95.6M | 1.4%Prev: 0.8% | 1,732,569 SH | Increased-456,023 SH |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | $136.3M | 2.0% | 6,999,025 SH | New |
| NEKTAR THERAPEUTICS | COM NEW | $20.9M | 0.3% | 300,000 SH | New |
| NURIX THERAPEUTICS INC | COM | $187.7M | 2.7%Prev: 2.2% | 7,736,455 SH | Increased+1,671,545 SH |
| NUVALENT INC | COM | $220.2M | 3.2% | 1,783,322 SH | New |
| OCULAR THERAPEUTIX INC | COM | $193.3M | 2.8%Prev: 4.3% | 19,686,282 SH | Increased+5,391,862 SH |
| OLEMA PHARMACEUTICALS INC | COM | $18.8M | 0.3%Prev: 0.5% | 1,500,000 SH | Increased-1,942,833 SH |
| ORUKA THERAPEUTICS INC | COM | $183.3M | 2.7%Prev: 0.7% | 1,926,000 SH | Increased+7,202 SH |
| PERSONALIS INC | COM | $53.6M | 0.8% | 4,000,000 SH | New |
| PROMIS NEUROSCIENCES INC | COM SHS | $11.0M | 0.2% | 835,655 SH | New |
| SHATTUCK LABS INC | COM | $25.7M | 0.4% | 3,706,734 SH | New |
| SOLID BIOSCIENCES INC | COM NEW | $35.6M | 0.5% | 3,565,062 SH | New |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $254.4M | 3.7%Prev: 3.4% | 4,740,072 SH | Increased-393,845 SH |
| TANGO THERAPEUTICS INC | COM | $131.3M | 1.9% | 4,200,000 SH | New |
| TARSUS PHARMACEUTICALS INC | COM | $230.8M | 3.4%Prev: 2.3% | 3,666,768 SH | Increased+1,916,768 SH |
| UNITED THERAPEUTICS CORP DEL | COM | $67.0M | 1.0% | 123,616 SH | New |
| VAXCYTE INC | COM | $250.0M | 3.6%Prev: 2.2% | 4,300,000 SH | Increased+2,150,000 SH |
| VERA THERAPEUTICS INC | CL A | $171.6M | 2.5% | 4,000,000 SH | New |
| VERADERMICS INC | COMMON STOCK | $245.9M | 3.6% | 2,000,000 SH | New |
| VERASTEM INC | COM NEW | $21.9M | 0.3% | 5,740,850 SH | New |
| VIRIDIAN THERAPEUTICS INC | COM | $66.0M | 1.0%Prev: 2.4% | 3,592,740 SH | Decreased-1,787,709 SH |
| X4 PHARMACEUTICALS INC | COM NEW | $27.5M | 0.4% | 5,878,757 SH | New |
| XENCOR INC | COM | $9.6M | 0.1%Prev: 0.1% | 593,551 SH | Increased+44,112 SH |