| 89BIO INC | COM | $137.5M | 3.8% | 9,356,171 SH | New |
| ACADIA PHARMACEUTICALS INC | COM | $2.2M | 0.1% | 105,085 SH | New |
| AKERO THERAPEUTICS INC | COM | $190.0M | 5.3% | 4,000,978 SH | New |
| ALIGOS THERAPEUTICS INC | COM NEW | $4.4M | 0.1%Prev: 0.0% | 444,110 SH | Increased |
| ANI PHARMACEUTICALS INC | COM | $41.2M | 1.2% | 450,000 SH | New |
| APELLIS PHARMACEUTICALS INC | COM | $181.0M | 5.1% | 8,000,382 SH | New |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | $4.2M | 0.1% | 2,568,613 SH | New |
| AVALO THERAPEUTICS INC | COM NEW | $1.8M | 0.1%Prev: 1.0% | 144,600 SH | Decreased-3,465,400 SH |
| AXSOME THERAPEUTICS INC | COM | $109.3M | 3.1% | 900,000 SH | New |
| BICARA THERAPEUTICS INC | COM | $38.3M | 1.1%Prev: 1.8% | 2,426,657 SH | Decreased-1,673,343 SH |
| BIOMARIN PHARMACEUTICAL INC | COM | $1.3M | 0.0%Prev: 2.8% | 24,856 SH | Decreased-3,282,625 SH |
| BRIDGEBIO PHARMA INC | COM | $62.3M | 1.7% | 1,200,000 SH | New |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | $51.7M | 1.4%Prev: 1.6% | 2,000,000 SH | Decreased-939,151 SH |
| CIDARA THERAPEUTICS INC | COM NEW | $28.7M | 0.8% | 300,000 SH | New |
| CLIMB BIO INC | COM | $1.0M | 0.0% | 509,789 SH | New |
| COMPASS PATHWAYS PLC | SPONSORED ADS | $45.0M | 1.3%Prev: 2.5% | 7,859,648 SH | Decreased-4,301,848 SH |
| CONTEXT THERAPEUTICS INC | COM | $7.2M | 0.2%Prev: 0.1% | 7,419,355 SH | Increased |
| CORMEDIX INC | COM | $5.8M | 0.2%Prev: 0.7% | 500,000 SH | Decreased-5,774,076 SH |
| CRESCENT BIOPHARMA INC. | COM | $5.4M | 0.2% | 453,686 SH | New |
| CYBIN INC | COM NEW | $5.9M | 0.2% | 1,000,000 SH | New |
| CYTOKINETICS INC | COM NEW | $236.3M | 6.6%Prev: 0.9% | 4,300,000 SH | Increased+3,600,000 SH |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | $156.2M | 4.4% | 15,726,349 SH | New |
| DYNE THERAPEUTICS INC | COM | $25.3M | 0.7%Prev: 0.5% | 2,000,000 SH | Decreased+500,000 SH |
| ENGENE HOLDINGS INC | COM | $15.3M | 0.4% | 2,239,353 SH | New |
| EXACT SCIENCES CORP | COM | $54.7M | 1.5% | 1,000,000 SH | New |
| GENMAB A/S | SPONSORED ADS | $14.8M | 0.4%Prev: 3.5% | 481,267 SH | Decreased-8,168,733 SH |
| GERON CORP | COM | $56.3M | 1.6% | 41,096,522 SH | New |
| GH RESEARCH PLC | ORDINARY SHARES | $17.9M | 0.5%Prev: 1.3% | 1,250,000 SH | Decreased-2,083,334 SH |
| GUARDANT HEALTH INC | COM | $259.5M | 7.2%Prev: 7.4% | 4,154,086 SH | Decreased+760,774 SH |
| IMAGENEBIO INC | COM | $7.2M | 0.2% | 878,516 SH | New |
| IMMUNOCORE HLDGS PLC | ADS | $65.4M | 1.8%Prev: 0.1% | 1,800,000 SH | Increased+1,488,782 SH |
| IMMUNOVANT INC | COM | $156.8M | 4.4%Prev: 5.2% | 9,728,845 SH | Decreased+387,694 SH |
| IONIS PHARMACEUTICALS INC | COM | $249.1M | 7.0%Prev: 2.5% | 3,808,144 SH | Increased+1,608,144 SH |
| JADE BIOSCIENCES INC | COM NEW | $19.7M | 0.5% | 2,279,892 SH | New |
| LB PHARMACEUTICALS INC | COM SHS | $52.9M | 1.5%Prev: 1.6% | 3,352,804 SH | Decreased |
| MAZE THERAPEUTICS INC | COM | $102.4M | 2.9%Prev: 1.6% | 3,948,910 SH | Decreased+216,341 SH |
| MBX BIOSCIENCES INC | COM | $55.1M | 1.5%Prev: 1.4% | 3,150,000 SH | Decreased+1,417,431 SH |
| MIND MEDICINE MINDMED INC | COM NEW | $17.7M | 0.5% | 1,500,000 SH | New |
| NURIX THERAPEUTICS INC | COM | $56.0M | 1.6%Prev: 2.7% | 6,057,024 SH | Decreased-1,679,431 SH |
| OCULAR THERAPEUTIX INC | COM | $139.5M | 3.9%Prev: 2.8% | 11,932,137 SH | Decreased-7,754,145 SH |
| OLEMA PHARMACEUTICALS INC | COM | $34.0M | 0.9%Prev: 0.3% | 3,470,172 SH | Increased+1,970,172 SH |
| ORUKA THERAPEUTICS INC | COM | $51.1M | 1.4%Prev: 2.7% | 2,654,781 SH | Decreased+728,781 SH |
| PEPGEN INC | COM | $5.5M | 0.2% | 1,200,000 SH | New |
| PROTAGONIST THERAPEUTICS INC | COM | $114.0M | 3.2% | 1,715,691 SH | New |
| RAPT THERAPEUTICS INC | COM NEW | $19.4M | 0.5% | 751,422 SH | New |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $118.0M | 3.3%Prev: 3.7% | 4,215,811 SH | Decreased-524,261 SH |
| TANGO THERAPEUTICS INC | COM | $12.2M | 0.3%Prev: 1.9% | 1,454,562 SH | Decreased-2,745,438 SH |
| TARSUS PHARMACEUTICALS INC | COM | $178.3M | 5.0%Prev: 3.4% | 3,000,000 SH | Decreased-666,768 SH |
| TERNS PHARMACEUTICALS INC | COM | $56.3M | 1.6% | 7,495,000 SH | New |
| UNIQURE NV | SHS | $28.2M | 0.8% | 483,092 SH | New |
| VAXCYTE INC | COM | $108.1M | 3.0%Prev: 3.6% | 3,000,000 SH | Decreased-1,300,000 SH |
| VIRIDIAN THERAPEUTICS INC | COM | $116.1M | 3.2%Prev: 1.0% | 5,380,449 SH | Increased+1,787,709 SH |
| X4 PHARMACEUTICALS INC | COM | $3.8M | 0.1% | 1,122,484 SH | New |
| XENCOR INC | COM | $6.4M | 0.2%Prev: 0.1% | 549,439 SH | Decreased-44,112 SH |
| XENON PHARMACEUTICALS INC | COM | $48.2M | 1.3% | 1,200,000 SH | New |
| ZURA BIO LTD | CLASS A ORD SHS | $1.1M | 0.0% | 259,014 SH | New |