| 89BIO INC | COM | $93.3M | 3.0% | 9,500,000 SH | New |
| ABIVAX SA | SPONSORED ADS | $26.6M | 0.9% | 3,480,144 SH | New |
| AKERO THERAPEUTICS INC | COM | $162.4M | 5.2% | 3,042,598 SH | New |
| ALIGOS THERAPEUTICS INC | COM NEW | $3.2M | 0.1%Prev: 0.1% | 444,110 SH | Decreased |
| ANI PHARMACEUTICALS INC | COM | $45.7M | 1.5%Prev: 0.8% | 700,000 SH | Decreased+100,000 SH |
| APELLIS PHARMACEUTICALS INC | COM | $121.2M | 3.9%Prev: 3.0% | 7,000,000 SH | Decreased+2,467,626 SH |
| AUTOLUS THERAPEUTICS PLC | SPON ADS | $38.4M | 1.2% | 16,852,147 SH | New |
| AVALO THERAPEUTICS INC | COM NEW | $2.8M | 0.1% | 567,103 SH | New |
| AXSOME THERAPEUTICS INC | COM | $83.7M | 2.7% | 801,371 SH | New |
| BICARA THERAPEUTICS INC | COM | $22.5M | 0.7%Prev: 1.3% | 2,426,657 SH | Decreased-1,635,843 SH |
| BICYCLE THERAPEUTICS PLC | SPONSORED ADS | $8.4M | 0.3% | 1,203,244 SH | New |
| BRIDGEBIO PHARMA INC | COM | $38.9M | 1.2%Prev: 1.0% | 900,000 SH | Decreased+58,555 SH |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | $40.7M | 1.3%Prev: 0.7% | 2,000,000 SH | Decreased+716,021 SH |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $6.6M | 0.2%Prev: 2.0% | 500,000 SH | Decreased-2,658,041 SH |
| CIDARA THERAPEUTICS INC | COM NEW | $12.2M | 0.4% | 250,000 SH | New |
| CLIMB BIO INC | COM | $1.3M | 0.0% | 1,040,115 SH | New |
| COMPASS PATHWAYS PLC | SPONSORED ADS | $24.7M | 0.8%Prev: 1.1% | 8,831,007 SH | Decreased-3,330,489 SH |
| CONTEXT THERAPEUTICS INC | COM | $4.9M | 0.2%Prev: 0.3% | 7,419,355 SH | Decreased |
| CRESCENT BIOPHARMA INC. | COM | $7.3M | 0.2%Prev: 0.1% | 453,686 SH | Decreased |
| CYBIN INC | COM NEW | $12.8M | 0.4%Prev: 0.1% | 1,529,987 SH | Increased+216,850 SH |
| CYTOKINETICS INC | COM NEW | $120.6M | 3.9%Prev: 1.5% | 3,650,000 SH | Increased+2,275,680 SH |
| DIANTHUS THERAPEUTICS INC | COM | $41.6M | 1.3% | 2,233,148 SH | New |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | $176.5M | 5.7% | 17,791,486 SH | New |
| ENGENE HOLDINGS INC | COM | $16.6M | 0.5%Prev: 0.5% | 4,557,575 SH | Decreased+180,003 SH |
| GERON CORP | COM | $60.6M | 1.9%Prev: 0.8% | 43,000,000 SH | Increased+11,279,722 SH |
| GH RESEARCH PLC | ORDINARY SHARES | $24.4M | 0.8% | 2,000,000 SH | New |
| GUARDANT HEALTH INC | COM | $221.2M | 7.1%Prev: 5.0% | 4,250,000 SH | Decreased+911,759 SH |
| IKENA ONCOLOGY INC | COM | $3.4M | 0.1% | 2,515,513 SH | New |
| IMMUNOCORE HLDGS PLC | ADS | $56.5M | 1.8%Prev: 1.0% | 1,800,000 SH | Decreased-131,884 SH |
| IMMUNOVANT INC | COM | $152.0M | 4.9%Prev: 4.7% | 9,500,000 SH | Decreased-2,026,971 SH |
| INOVIO PHARMACEUTICALS INC | COM SHS | $4.0M | 0.1% | 1,981,370 SH | New |
| INSMED INC | COM PAR $.01 | $176.1M | 5.6% | 1,750,000 SH | New |
| INVIVYD INC | COM | $6.1M | 0.2% | 8,585,980 SH | New |
| IONIS PHARMACEUTICALS INC | COM | $193.3M | 6.2%Prev: 2.4% | 4,891,544 SH | Increased+2,941,544 SH |
| JADE BIOSCIENCES INC | COM NEW | $25.1M | 0.8% | 2,509,301 SH | New |
| KORRO BIO INC | COM | $3.5M | 0.1% | 277,966 SH | New |
| MAZE THERAPEUTICS INC | COM | $48.5M | 1.6%Prev: 1.7% | 3,948,910 SH | Decreased+471,348 SH |
| MBX BIOSCIENCES INC | COM | $25.0M | 0.8%Prev: 1.3% | 2,188,592 SH | Decreased-568,977 SH |
| MERUS N V | COM | $14.5M | 0.5% | 275,000 SH | New |
| METSERA INC | COM | $31.1M | 1.0% | 1,094,408 SH | New |
| MIND MEDICINE MINDMED INC | COM NEW | $16.2M | 0.5% | 2,500,000 SH | New |
| NOVAVAX INC | COM NEW | $6.3M | 0.2% | 998,542 SH | New |
| NURIX THERAPEUTICS INC | COM | $69.1M | 2.2%Prev: 1.6% | 6,064,910 SH | Decreased-280,334 SH |
| OCULAR THERAPEUTIX INC | COM | $132.7M | 4.3%Prev: 2.7% | 14,294,420 SH | Decreased-5,391,862 SH |
| OLEMA PHARMACEUTICALS INC | COM | $14.7M | 0.5% | 3,442,833 SH | New |
| ONKURE THERAPEUTICS INC | COM CL A | $431K | 0.0% | 180,510 SH | New |
| ORUKA THERAPEUTICS INC | COM | $21.5M | 0.7%Prev: 1.6% | 1,918,798 SH | Decreased-115,405 SH |
| PLIANT THERAPEUTICS INC | COM | $4.6M | 0.1% | 3,947,807 SH | New |
| PROTAGONIST THERAPEUTICS INC | COM | $179.4M | 5.8% | 3,245,899 SH | New |
| RAPPORT THERAPEUTICS INC | COM | $1.1M | 0.0% | 98,237 SH | New |
| RAPT THERAPEUTICS INC | COM NEW | $6.0M | 0.2% | 751,422 SH | New |
| SAREPTA THERAPEUTICS INC | COM | $12.1M | 0.4% | 709,800 SH | New |
| SEPTERNA INC | COM | $1.3M | 0.0% | 121,716 SH | New |
| SPYRE THERAPEUTICS INC | COM NEW | $3.3M | 0.1% | 219,015 SH | New |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $106.5M | 3.4%Prev: 3.4% | 5,133,917 SH | Decreased+854,069 SH |
| TARSUS PHARMACEUTICALS INC | COM | $70.9M | 2.3%Prev: 4.1% | 1,750,000 SH | Decreased-1,850,000 SH |
| TECTONIC THERAPEUTIC INC | COM | $27.9M | 0.9% | 1,401,938 SH | New |
| TERNS PHARMACEUTICALS INC | COM | $28.0M | 0.9%Prev: 0.9% | 7,495,000 SH | Decreased+6,421,123 SH |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $49.1M | 1.6% | 1,350,000 SH | New |
| UPSTREAM BIO INC | COM | $15.8M | 0.5% | 1,442,767 SH | New |
| VAXCYTE INC | COM | $69.9M | 2.2%Prev: 4.1% | 2,150,000 SH | Decreased-2,150,000 SH |
| VIRIDIAN THERAPEUTICS INC | COM | $75.2M | 2.4%Prev: 0.4% | 5,380,449 SH | Increased+3,986,505 SH |
| XENCOR INC | COM | $4.3M | 0.1% | 549,439 SH | New |
| XENON PHARMACEUTICALS INC | COM | $42.3M | 1.4% | 1,350,000 SH | New |
| ZURA BIO LTD | CLASS A ORD SHS | $1.8M | 0.1% | 1,727,562 SH | New |