| ADLAI NORTYE LTD | SPONSORED ADS | $49K | 0.0% | 34,852 SH | New |
| ALIGOS THERAPEUTICS INC | COM NEW | $4.1M | 0.1%Prev: 0.1% | 444,110 SH | Decreased |
| ALKERMES PLC | SHS | $56.0M | 1.0% | 2,000,000 SH | New |
| ANI PHARMACEUTICALS INC | COM | $37.7M | 0.7%Prev: 1.2% | 477,684 SH | Decreased+27,684 SH |
| APELLIS PHARMACEUTICALS INC | COM | $194.7M | 3.5%Prev: 5.1% | 7,750,000 SH | Increased-250,382 SH |
| ATAI BECKLEY NV | SHS | $19.1M | 0.3% | 4,677,289 SH | New |
| AXSOME THERAPEUTICS INC | COM | $210.0M | 3.7%Prev: 3.1% | 1,150,000 SH | Increased+250,000 SH |
| BICARA THERAPEUTICS INC | COM | $44.0M | 0.8%Prev: 1.1% | 2,614,004 SH | Increased+187,347 SH |
| BILLIONTOONE INC | CL A | $4.1M | 0.1% | 50,000 SH | New |
| BIOHAVEN LTD | COM | $5.6M | 0.1% | 500,000 SH | New |
| BIOMARIN PHARMACEUTICAL INC | COM | $136.7M | 2.4%Prev: 0.0% | 2,300,000 SH | Increased+2,275,144 SH |
| BRIDGEBIO PHARMA INC | COM | $62.0M | 1.1%Prev: 1.7% | 810,142 SH | Decreased-389,858 SH |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | $51.6M | 0.9%Prev: 1.4% | 1,900,738 SH | Decreased-99,262 SH |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $50.0M | 0.9% | 2,000,000 SH | New |
| COGENT BIOSCIENCES INC | COM | $16.1M | 0.3% | 453,102 SH | New |
| COMPASS PATHWAYS PLC | SPONSORED ADS | $50.6M | 0.9%Prev: 1.3% | 7,334,323 SH | Increased-525,325 SH |
| CONTEXT THERAPEUTICS INC | COM | $10.9M | 0.2%Prev: 0.2% | 7,419,355 SH | Increased |
| CORMEDIX INC | COM | $61.3M | 1.1%Prev: 0.2% | 5,274,076 SH | Increased+4,774,076 SH |
| CRESCENT BIOPHARMA INC. | COM | $5.4M | 0.1%Prev: 0.2% | 453,686 SH | Decreased |
| CYBIN INC | COM NEW | $15.2M | 0.3%Prev: 0.2% | 1,854,255 SH | Increased+854,255 SH |
| CYTOKINETICS INC | COM NEW | $212.0M | 3.8%Prev: 6.6% | 3,336,998 SH | Decreased-963,002 SH |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | $241.9M | 4.3%Prev: 4.4% | 15,726,349 SH | Increased |
| DYNE THERAPEUTICS INC | COM | $51.8M | 0.9%Prev: 0.7% | 2,650,000 SH | Increased+650,000 SH |
| ENANTA PHARMACEUTICALS INC | COM | $30.9M | 0.6% | 1,956,867 SH | New |
| ENGENE HOLDINGS INC | COM | $39.5M | 0.7%Prev: 0.4% | 4,377,572 SH | Increased+2,138,219 SH |
| GERON CORP | COM | $42.9M | 0.8%Prev: 1.6% | 32,511,271 SH | Decreased-8,585,251 SH |
| GRAIL INC | COM | $87.5M | 1.6% | 1,022,797 SH | New |
| GUARDANT HEALTH INC | COM | $286.0M | 5.1%Prev: 7.2% | 2,800,000 SH | Increased-1,354,086 SH |
| IMMUNOCORE HLDGS PLC | ADS | $69.6M | 1.2%Prev: 1.8% | 2,003,978 SH | Increased+203,978 SH |
| IMMUNOVANT INC | COM | $293.0M | 5.2%Prev: 4.4% | 11,526,971 SH | Increased+1,798,126 SH |
| INVENTIVA SA | ADS | $2.3M | 0.0% | 490,000 SH | New |
| IONIS PHARMACEUTICALS INC | COM | $134.5M | 2.4%Prev: 7.0% | 1,700,000 SH | Decreased-2,108,144 SH |
| JANUX THERAPEUTICS INC | COM | $1.2M | 0.0% | 89,589 SH | New |
| LB PHARMACEUTICALS INC | COM SHS | $74.6M | 1.3%Prev: 1.5% | 3,352,804 SH | Increased |
| MAZE THERAPEUTICS INC | COM | $175.9M | 3.1%Prev: 2.9% | 4,246,440 SH | Increased+297,530 SH |
| MBX BIOSCIENCES INC | COM | $102.5M | 1.8%Prev: 1.5% | 3,249,790 SH | Increased+99,790 SH |
| MIND MEDICINE MINDMED INC | COM NEW | $22.4M | 0.4%Prev: 0.5% | 1,676,540 SH | Increased+176,540 SH |
| MONOPAR THERAPEUTICS INC | COM NEW | $6.2M | 0.1% | 95,408 SH | New |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | $60.8M | 1.1% | 4,610,071 SH | New |
| NURIX THERAPEUTICS INC | COM | $133.5M | 2.4%Prev: 1.6% | 7,036,455 SH | Increased+979,431 SH |
| OCULAR THERAPEUTIX INC | COM | $98.0M | 1.7%Prev: 3.9% | 8,070,414 SH | Decreased-3,861,723 SH |
| ORUKA THERAPEUTICS INC | COM | $65.5M | 1.2%Prev: 1.4% | 2,161,510 SH | Increased-493,271 SH |
| RAPT THERAPEUTICS INC | COM NEW | $3.7M | 0.1%Prev: 0.5% | 110,448 SH | Decreased-640,974 SH |
| SOLENO THERAPEUTICS INC | COM | $46.3M | 0.8% | 1,000,000 SH | New |
| SPDR SERIES TRUST | STATE STREET SPD | $1.22B | 21.7% | 10,000,000 SH | New |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $286.0M | 5.1%Prev: 3.3% | 4,111,782 SH | Increased-104,029 SH |
| TANGO THERAPEUTICS INC | COM | $21.7M | 0.4%Prev: 0.3% | 2,454,562 SH | Increased+1,000,000 SH |
| TARSUS PHARMACEUTICALS INC | COM | $246.0M | 4.4%Prev: 5.0% | 3,004,034 SH | Increased+4,034 SH |
| TERNS PHARMACEUTICALS INC | COM | $31.1M | 0.6%Prev: 1.6% | 769,048 SH | Decreased-6,725,952 SH |
| VAXCYTE INC | COM | $184.6M | 3.3%Prev: 3.0% | 4,000,000 SH | Increased+1,000,000 SH |
| VERA THERAPEUTICS INC | CL A | $142.9M | 2.5% | 2,821,135 SH | New |
| VERASTEM INC | COM NEW | $44.3M | 0.8% | 5,740,850 SH | New |
| VIRIDIAN THERAPEUTICS INC | COM | $78.6M | 1.4%Prev: 3.2% | 2,524,833 SH | Decreased-2,855,616 SH |
| X4 PHARMACEUTICALS INC | COM NEW | $20.1M | 0.4% | 5,013,661 SH | New |
| XENON PHARMACEUTICALS INC | COM | $16.4M | 0.3%Prev: 1.3% | 366,435 SH | Decreased-833,565 SH |