| ABEONA THERAPEUTICS INC | COM NEW | $673K | 0.1%Prev: 0.1% | 108,865 SH | Increased |
| ACADIA PHARMACEUTICALS INC | COM | $72.5M | 10.0%Prev: 11.8% | 2,864,096 SH | Increased+300,887 SH |
| ACLARIS THERAPEUTICS INC | COM | $8.5M | 1.2%Prev: 0.4% | 1,613,430 SH | Increased+223,402 SH |
| AGIOS PHARMACEUTICALS INC | COM | $7.9M | 1.1%Prev: 1.9% | 213,601 SH | Decreased-55,182 SH |
| ALDEYRA THERAPEUTICS INC | COM | $332K | 0.0% | 155,709 SH | New |
| ALIGN TECHNOLOGY INC | COM | $5.3M | 0.7%Prev: 1.5% | 31,389 SH | Decreased-6,383 SH |
| ALKERMES PLC | SHS | $12.7M | 1.8% | 242,560 SH | New |
| ANAPTYSBIO INC | COM | $40.7M | 5.6%Prev: 3.8% | 603,489 SH | Increased-209,332 SH |
| ANNEXON INC | COM | $16.8M | 2.3% | 2,948,090 SH | New |
| BICARA THERAPEUTICS INC | COM | $16.3M | 2.3% | 550,408 SH | New |
| BICYCLE THERAPEUTICS PLC-ADR | SPONSORED ADS | $856K | 0.1% | 201,890 SH | New |
| BIOGEN INC | COM | $30.3M | 4.2% | 140,279 SH | New |
| BIOMARIN PHARMACEUTICAL INC | COM | $39.1M | 5.4%Prev: 9.8% | 682,777 SH | Decreased-157,693 SH |
| BIONTECH SE-ADR | SPONSORED ADS | $1.8M | 0.3% | 19,614 SH | New |
| CAPRICOR THERAPEUTICS INC | COM NEW | $5.5M | 0.8% | 229,763 SH | New |
| CAREDX INC | COM | $15.2M | 2.1% | 531,870 SH | New |
| CELLDEX THERAPEUTICS INC | COM NEW | $14.9M | 2.1% | 399,856 SH | New |
| COMPASS PATHWAYS PLC ADR | SPONSORED ADS | $1.6M | 0.2% | 115,616 SH | New |
| COMPASS THERAPEUTICS INC | COM | $12.8M | 1.8% | 5,831,813 SH | New |
| CRISPR THERAPEUTICS AG | NAMEN AKT | $2.2M | 0.3%Prev: 0.5% | 39,605 SH | Decreased-5,020 SH |
| CYTOKINETICS INC | COM NEW | $2.7M | 0.4% | 32,195 SH | New |
| DISC MEDICINE INC | COM | $30.5M | 4.2%Prev: 1.6% | 416,646 SH | Increased+270,955 SH |
| DYNE THERAPEUTICS INC | COM | $36.6M | 5.1% | 1,647,521 SH | New |
| EDWARDS LIFESCIENCES CORP | COM | $3.0M | 0.4%Prev: 0.7% | 33,640 SH | Decreased-5,833 SH |
| EHEALTH INC | COM | $2.2M | 0.3%Prev: 1.5% | 1,482,797 SH | Decreased-95,053 SH |
| FIRST TRACKS BIOTHERAPEUTICS | ORD SHS | $12.1M | 1.7% | 603,489 SH | New |
| HUMANA INC | COM | $1.6M | 0.2%Prev: 0.2% | 3,985 SH | Increased |
| INSMED INC | COM PAR $.01 | $44.1M | 6.1% | 413,980 SH | New |
| INSPIRE MEDICAL SYSTEMS INC | COM | $391K | 0.1% | 8,772 SH | New |
| IOVANCE BIOTHERAPEUTICS INC | COM | $22.0M | 3.0% | 5,296,209 SH | New |
| MADRIGAL PHARMACEUTICALS INC | COM | $960K | 0.1% | 1,787 SH | New |
| MIRUM PHARMACEUTICALS INC | COM | $40.8M | 5.6%Prev: 0.7% | 348,808 SH | Increased+284,108 SH |
| NEUROCRINE BIOSCIENCES INC | COM | $3.1M | 0.4%Prev: 0.4% | 18,117 SH | Increased+4,783 SH |
| NEWAMSTERDAM PHARMA CO NV | ORDINARY SHARES | $1.5M | 0.2% | 44,359 SH | New |
| NOVOCURE LTD | ORD SHS | $19.4M | 2.7% | 1,280,439 SH | New |
| NUVATION BIO INC | COM CL A | $1.9M | 0.3% | 326,609 SH | New |
| ORUKA THERAPEUTICS INC - Restricted | COM | $3.2M | 0.4% | 33,546 SH | New |
| PROQR THERAPEUTICS NV | SHS EURO | $351K | 0.0% | 188,807 SH | New |
| PROTHENA CORP PLC | SHS | $11.2M | 1.5% | 1,143,155 SH | New |
| PTC THERAPEUTICS INC | COM | $75.0M | 10.4% | 918,846 SH | New |
| PYXIS ONCOLOGY INC | COMMON STOCK | $2.6M | 0.4% | 864,277 SH | New |
| SAGIMET BIOSCIENCES INC-A | COM SER A | $1.9M | 0.3% | 250,000 SH | New |
| STOKE THERAPEUTICS INC | COM | $2.8M | 0.4% | 84,631 SH | New |
| SYNDAX PHARMACEUTICALS INC | COM | $18.9M | 2.6%Prev: 0.9% | 864,986 SH | Increased+420,619 SH |
| TAYSHA GENE THERAPIES INC | COM SHS | $9.5M | 1.3% | 1,391,382 SH | New |
| TRAVERE THERAPEUTICS INC | COM | $9.5M | 1.3% | 167,525 SH | New |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $19.9M | 2.8%Prev: 0.4% | 596,495 SH | Increased+547,745 SH |
| UNITED THERAPEUTICS CORP | COM | $33.9M | 4.7%Prev: 5.8% | 62,587 SH | Increased-32,895 SH |
| UROGEN PHARMA LTD | COM | $902K | 0.1%Prev: 0.1% | 24,500 SH | Increased |
| VERASTEM INC | COM NEW | $1.2M | 0.2% | 309,685 SH | New |
| XENON PHARMACEUTICALS INC | COM | $3.1M | 0.4% | 51,345 SH | New |
| XERIS BIOPHARMA HOLDINGS INC | COM | $827K | 0.1% | 104,410 SH | New |