| ABEONA THERAPEUTICS INC | COM NEW | $618K | 0.1%Prev: 0.1% | 108,865 SH | Increased |
| ACADIA PHARMACEUTICALS INC | COM | $55.3M | 11.8%Prev: 9.8% | 2,563,209 SH | Decreased-309,486 SH |
| ACLARIS THERAPEUTICS INC | COM | $2.0M | 0.4%Prev: 0.9% | 1,390,028 SH | Decreased-223,402 SH |
| AGIOS PHARMACEUTICALS INC | COM | $8.9M | 1.9%Prev: 1.1% | 268,783 SH | Increased+55,182 SH |
| AKARI THERAPEUTICS PLC-ADR | COM | $171K | 0.0% | 146,024 SH | New |
| ALDEYRA THERAPEUTICS INC | SPONSORED ADR | $864K | 0.2% | 225,465 SH | New |
| ALIGN TECHNOLOGY INC | COM | $7.2M | 1.5%Prev: 1.1% | 37,772 SH | Increased-3,748 SH |
| ALKERMES PLC | COM | $6.3M | 1.3% | 221,021 SH | New |
| ALNYLAM PHARMACEUTICALS INC | SHS | $24.6M | 5.2% | 75,535 SH | New |
| ALUMIS INC | COM | $430K | 0.1% | 143,437 SH | New |
| AMICUS THERAPEUTICS INC | COM | $32.1M | 6.8%Prev: 2.5% | 5,610,513 SH | Increased+4,497,468 SH |
| ANAPTYSBIO INC | COM | $18.0M | 3.8%Prev: 5.4% | 812,821 SH | Decreased+174,660 SH |
| AVIDITY BIOSCIENCES INC | COM | $3.4M | 0.7% | 118,886 SH | New |
| BICYCLE THERAPEUTICS PLC-ADR | COM | $1.7M | 0.4% | 248,934 SH | New |
| BIOGEN INC | SPONSORED ADS | $25.8M | 5.5% | 205,759 SH | New |
| BIOMARIN PHARMACEUTICAL INC | COM | $46.2M | 9.8%Prev: 5.9% | 840,470 SH | Increased+155,288 SH |
| BIONTECH SE-ADR | COM | $2.7M | 0.6% | 25,206 SH | New |
| CRISPR THERAPEUTICS AG | NAMEN AKT | $2.2M | 0.5%Prev: 0.3% | 44,625 SH | Increased+5,020 SH |
| DENALI THERAPEUTICS INC | COM | $3.4M | 0.7%Prev: 0.7% | 239,809 SH | Decreased+5,227 SH |
| DISC MEDICINE INC | COM | $7.7M | 1.6%Prev: 3.9% | 145,691 SH | Decreased-256,028 SH |
| DYNE THERAPEUTICS INC | SPONSORED ADS | $2.5M | 0.5% | 264,976 SH | New |
| EDWARDS LIFESCIENCES CORP | COM | $3.1M | 0.7%Prev: 0.4% | 39,473 SH | Increased+5,833 SH |
| EHEALTH INC | COM | $6.9M | 1.5%Prev: 0.3% | 1,577,850 SH | Increased+95,053 SH |
| GENERATION BIO CO | COM | $48K | 0.0% | 150,475 SH | New |
| GOSSAMER BIO INC | COM | $7.1M | 1.5% | 5,739,013 SH | New |
| HUMANA INC | COM | $974K | 0.2%Prev: 0.1% | 3,985 SH | Increased |
| INSMED INC | COM | $87.1M | 18.5% | 865,113 SH | New |
| IOVANCE BIOTHERAPEUTICS INC | COM NEW | $5.9M | 1.3% | 3,429,329 SH | New |
| KARYOPHARM THERAPEUTICS INC | COM | $810K | 0.2% | 187,911 SH | New |
| MIRUM PHARMACEUTICALS INC | COM | $3.3M | 0.7%Prev: 4.6% | 64,700 SH | Decreased-260,475 SH |
| NEUROCRINE BIOSCIENCES INC | COM | $1.7M | 0.4%Prev: 0.4% | 13,334 SH | Decreased-4,783 SH |
| NOVOCURE LTD | COM | $17.1M | 3.6% | 962,396 SH | New |
| NUVATION BIO INC | ORD SHS | $1.5M | 0.3% | 772,652 SH | New |
| PROTHENA CORP PLC | COM CL A | $7.7M | 1.6% | 1,274,753 SH | New |
| PTC THERAPEUTICS INC | SHS | $19.9M | 4.2% | 406,469 SH | New |
| PYXIS ONCOLOGY INC | COM | $1.1M | 0.2% | 1,037,421 SH | New |
| STAAR SURGICAL CO | COM | $13.3M | 2.8% | 791,879 SH | New |
| STOKE THERAPEUTICS INC | COM PAR $0.01 | $1.4M | 0.3% | 125,861 SH | New |
| SYNDAX PHARMACEUTICALS INC | COM | $4.2M | 0.9%Prev: 3.1% | 444,367 SH | Decreased-420,619 SH |
| TAYSHA GENE THERAPIES INC | COM | $2.9M | 0.6% | 1,246,033 SH | New |
| TRAVERE THERAPEUTICS INC | COM SHS | $1.6M | 0.3% | 110,719 SH | New |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $1.8M | 0.4%Prev: 1.9% | 48,750 SH | Decreased-547,745 SH |
| UNITED THERAPEUTICS CORP | COM | $27.4M | 5.8%Prev: 5.7% | 95,482 SH | Decreased+32,673 SH |
| UROGEN PHARMA LTD | COM | $336K | 0.1%Prev: 0.1% | 24,500 SH | Decreased |
| VYNE THERAPEUTICS INC PIPE | COM | $735K | 0.2% | 445,434 SH | New |