| ABEONA THERAPEUTICS INC | COM NEW | $488K | 0.1%Prev: 0.1% | 108,865 SH | Decreased |
| ACADIA PHARMACEUTICALS INC | COM | $63.9M | 9.8%Prev: 8.4% | 2,872,695 SH | Increased+208,770 SH |
| ACLARIS THERAPEUTICS INC | COM | $6.1M | 0.9%Prev: 0.2% | 1,613,430 SH | Increased+837,402 SH |
| AGIOS PHARMACEUTICALS INC | COM | $7.2M | 1.1%Prev: 1.5% | 213,601 SH | Decreased-62,977 SH |
| ALDEYRA THERAPEUTICS INC | COM | $263K | 0.0%Prev: 0.2% | 155,709 SH | Decreased-69,756 SH |
| ALIGN TECHNOLOGY INC | COM | $7.1M | 1.1%Prev: 1.1% | 41,520 SH | Increased+3,748 SH |
| ALKERMES PLC | SHS | $8.6M | 1.3%Prev: 1.4% | 242,560 SH | Increased+21,047 SH |
| AMICUS THERAPEUTICS INC | COM | $16.1M | 2.5%Prev: 11.4% | 1,113,045 SH | Decreased-6,231,957 SH |
| ANAPTYSBIO INC | COM | $35.4M | 5.4%Prev: 3.6% | 638,161 SH | Increased-382,552 SH |
| ANNEXON INC | COM | $16.3M | 2.5% | 2,948,090 SH | New |
| BICARA THERAPEUTICS INC | COM | $10.9M | 1.7% | 550,408 SH | New |
| BICYCLE THERAPEUTICS PLC-ADR | SPONSORED ADS | $937K | 0.1%Prev: 0.4% | 201,890 SH | Decreased-47,044 SH |
| BIOGEN INC | COM | $25.8M | 3.9%Prev: 5.3% | 140,719 SH | Decreased-64,204 SH |
| BIOMARIN PHARMACEUTICAL INC | COM | $38.7M | 5.9%Prev: 13.3% | 685,182 SH | Decreased-306,025 SH |
| BIONTECH SE-ADR | SPONSORED ADS | $1.7M | 0.3%Prev: 0.4% | 19,614 SH | Decreased-5,592 SH |
| CAPRICOR THERAPEUTICS INC | COM NEW | $7.0M | 1.1% | 229,763 SH | New |
| CAREDX INC | COM | $9.2M | 1.4% | 531,870 SH | New |
| CELLDEX THERAPEUTICS INC | COM NEW | $9.4M | 1.4% | 296,408 SH | New |
| COMPASS PATHWAYS PLC ADR | SPONSORED ADS | $639K | 0.1% | 115,616 SH | New |
| COMPASS THERAPEUTICS INC | COM | $8.0M | 1.2% | 1,514,504 SH | New |
| CRISPR THERAPEUTICS AG | NAMEN AKT | $1.9M | 0.3% | 39,605 SH | New |
| CYTOKINETICS INC | COM NEW | $2.1M | 0.3% | 32,195 SH | New |
| DENALI THERAPEUTICS INC | COM | $4.5M | 0.7% | 234,582 SH | New |
| DISC MEDICINE INC | COM | $25.7M | 3.9% | 401,719 SH | New |
| DYNE THERAPEUTICS INC | COM | $30.0M | 4.6%Prev: 0.7% | 1,652,972 SH | Increased+1,319,581 SH |
| EDWARDS LIFESCIENCES CORP | COM | $2.7M | 0.4%Prev: 0.5% | 33,640 SH | Decreased-5,833 SH |
| EHEALTH INC | COM | $1.9M | 0.3%Prev: 2.1% | 1,482,797 SH | Decreased-201,539 SH |
| HUMANA INC | COM | $691K | 0.1%Prev: 0.2% | 3,985 SH | Decreased |
| INSMED INC | COM PAR $.01 | $67.9M | 10.4%Prev: 14.3% | 415,269 SH | Decreased-571,884 SH |
| INSPIRE MEDICAL SYSTEMS INC | COM | $452K | 0.1% | 8,772 SH | New |
| IOVANCE BIOTHERAPEUTICS INC | COM | $22.3M | 3.4%Prev: 2.0% | 6,349,563 SH | Increased+3,138,249 SH |
| MADRIGAL PHARMACEUTICALS INC | COM | $935K | 0.1% | 1,787 SH | New |
| MIRUM PHARMACEUTICALS INC | COM | $30.0M | 4.6%Prev: 0.6% | 325,175 SH | Increased+260,475 SH |
| NEUROCRINE BIOSCIENCES INC | COM | $2.4M | 0.4%Prev: 0.3% | 18,117 SH | Increased+4,783 SH |
| NOVOCURE LTD | ORD SHS | $14.0M | 2.1%Prev: 3.4% | 1,280,439 SH | Decreased+278,378 SH |
| NUVATION BIO INC | COM CL A | $2.2M | 0.3%Prev: 0.3% | 508,846 SH | Increased-263,806 SH |
| ORUKA THERAPEUTICS INC | COM | $2.9M | 0.4% | 59,985 SH | New |
| PROQR THERAPEUTICS NV | SHS EURO | $306K | 0.0% | 188,807 SH | New |
| PROTHENA CORP PLC | SHS | $11.7M | 1.8%Prev: 3.9% | 1,208,568 SH | Decreased-451,166 SH |
| PTC THERAPEUTICS INC | COM | $62.8M | 9.6%Prev: 3.9% | 921,607 SH | Increased+517,411 SH |
| PYXIS ONCOLOGY INC | COMMON STOCK | $1.5M | 0.2%Prev: 0.2% | 1,010,510 SH | Increased-26,911 SH |
| STOKE THERAPEUTICS INC | COM | $2.8M | 0.4%Prev: 0.2% | 84,631 SH | Increased-41,230 SH |
| SYNDAX PHARMACEUTICALS INC | COM | $20.2M | 3.1%Prev: 1.0% | 864,986 SH | Increased+420,619 SH |
| TAYSHA GENE THERAPIES INC | COM SHS | $6.2M | 1.0%Prev: 0.4% | 1,391,382 SH | Increased-28,086 SH |
| TRAVERE THERAPEUTICS INC | COM | $6.8M | 1.0%Prev: 0.4% | 230,453 SH | Increased+119,734 SH |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $12.5M | 1.9% | 596,495 SH | New |
| UNITED THERAPEUTICS CORP | COM | $37.2M | 5.7%Prev: 6.2% | 62,809 SH | Increased-42,419 SH |
| UROGEN PHARMA LTD | COM | $441K | 0.1%Prev: 0.1% | 24,500 SH | Increased |
| VERASTEM INC | COM NEW | $1.3M | 0.2% | 246,093 SH | New |
| XENON PHARMACEUTICALS INC | COM | $3.0M | 0.5% | 51,345 SH | New |
| XERIS BIOPHARMA HOLDINGS INC | COM | $606K | 0.1% | 104,410 SH | New |