| ABEONA THERAPEUTICS INC | COM NEW | $574K | 0.1%Prev: 0.1% | 108,865 SH | Decreased |
| ACADIA PHARMACEUTICALS INC | COM | $66.3M | 9.2%Prev: 9.7% | 2,484,031 SH | Increased+17,347 SH |
| ACLARIS THERAPEUTICS INC | COM | $4.7M | 0.7%Prev: 0.6% | 1,566,840 SH | Increased |
| AGIOS PHARMACEUTICALS INC | COM | $5.8M | 0.8%Prev: 2.0% | 212,499 SH | Decreased-52,998 SH |
| AKARI THERAPEUTICS PLC-ADR | COM | $42K | 0.0%Prev: 0.0% | 146,024 SH | Decreased |
| ALDEYRA THERAPEUTICS INC | SPONSORED ADR | $1.2M | 0.2%Prev: 0.2% | 225,465 SH | Decreased |
| ALIGN TECHNOLOGY INC | COM | $6.5M | 0.9%Prev: 1.1% | 41,520 SH | Increased-4,215 SH |
| ALKERMES PLC | COM | $6.8M | 0.9%Prev: 1.0% | 242,560 SH | Increased+58,622 SH |
| AMICUS THERAPEUTICS INC | COM | $74.1M | 10.3%Prev: 7.8% | 5,205,767 SH | Increased-162,031 SH |
| ANAPTYSBIO INC | COM | $33.5M | 4.7%Prev: 3.8% | 690,032 SH | Increased+16,512 SH |
| ANNEXON INC | COM | $12.0M | 1.7% | 2,384,192 SH | New |
| BICARA THERAPEUTICS INC | COM | $5.0M | 0.7% | 298,575 SH | New |
| BICYCLE THERAPEUTICS PLC-ADR | COM | $1.6M | 0.2%Prev: 0.3% | 221,071 SH | Decreased |
| BIOGEN INC | SPONSORED ADS | $32.3M | 4.5%Prev: 4.8% | 183,571 SH | Increased-2,090 SH |
| BIOMARIN PHARMACEUTICAL INC | COM | $44.3M | 6.2%Prev: 7.6% | 746,256 SH | Increased-7,751 SH |
| BIONTECH SE-ADR | COM | $1.9M | 0.3%Prev: 0.4% | 19,614 SH | Decreased |
| CAPRICOR THERAPEUTICS INC | COM NEW | $6.5M | 0.9% | 226,304 SH | New |
| CAREDX INC | COM | $9.0M | 1.3%Prev: 0.9% | 478,220 SH | Increased+162,016 SH |
| COMPASS PATHWAYS PLC ADR | SPONSORED ADS | $798K | 0.1% | 115,616 SH | New |
| COMPASS THERAPEUTICS INC | COM | $13.6M | 1.9% | 2,532,419 SH | New |
| CRISPR THERAPEUTICS AG | NAMEN AKT | $2.2M | 0.3%Prev: 0.5% | 41,226 SH | Decreased |
| DENALI THERAPEUTICS INC | COM | $10.6M | 1.5%Prev: 1.1% | 641,239 SH | Increased+233,233 SH |
| DISC MEDICINE INC | COM | $25.2M | 3.5%Prev: 2.7% | 317,456 SH | Increased+93,156 SH |
| DYNE THERAPEUTICS INC | SPONSORED ADS | $28.8M | 4.0%Prev: 3.0% | 1,472,197 SH | Increased+209,523 SH |
| EDWARDS LIFESCIENCES CORP | COM | $2.9M | 0.4%Prev: 0.5% | 33,640 SH | Increased |
| EHEALTH INC | COM | $7.0M | 1.0%Prev: 1.2% | 1,531,429 SH | Increased-13,190 SH |
| GENERATION BIO CO | COM | $85K | 0.0%Prev: 0.0% | 15,047 SH | Decreased |
| GOSSAMER BIO INC | COM | $13.9M | 1.9%Prev: 2.7% | 4,471,592 SH | Decreased-992,757 SH |
| HUMANA INC | COM | $1.0M | 0.1%Prev: 0.2% | 3,985 SH | Decreased |
| INSMED INC | COM | $85.2M | 11.9%Prev: 13.1% | 489,482 SH | Increased-2,323 SH |
| INSPIRE MEDICAL SYSTEMS INC | COM | $809K | 0.1% | 8,772 SH | New |
| IOVANCE BIOTHERAPEUTICS INC | COM NEW | $19.4M | 2.7%Prev: 3.1% | 7,116,676 SH | Increased-501,456 SH |
| MIRUM PHARMACEUTICALS INC | COM | $12.4M | 1.7%Prev: 0.9% | 156,421 SH | Increased+91,721 SH |
| NEUROCRINE BIOSCIENCES INC | COM | $2.6M | 0.4%Prev: 0.5% | 18,117 SH | Increased |
| NOVOCURE LTD | COM | $16.8M | 2.3%Prev: 3.0% | 1,298,964 SH | Increased+42,805 SH |
| NUVATION BIO INC | COM CL A | $4.8M | 0.7%Prev: 0.7% | 538,079 SH | Increased-482,468 SH |
| ORUKA THERAPEUTICS INC | COM | $1.8M | 0.3%Prev: 0.1% | 59,985 SH | Increased |
| PROQR THERAPEUTICS NV | SHS EURO | $381K | 0.1%Prev: 0.1% | 188,807 SH | Decreased |
| PROTHENA CORP PLC | COM CL A | $12.6M | 1.8%Prev: 2.4% | 1,320,510 SH | Decreased-3,518 SH |
| PTC THERAPEUTICS INC | COM | $68.7M | 9.6%Prev: 9.8% | 903,916 SH | Increased+41,303 SH |
| PYXIS ONCOLOGY INC | COM | $1.2M | 0.2%Prev: 0.4% | 1,037,421 SH | Decreased |
| STOKE THERAPEUTICS INC | COM | $2.3M | 0.3%Prev: 0.5% | 72,022 SH | Decreased-33,405 SH |
| SYNDAX PHARMACEUTICALS INC | COM | $16.7M | 2.3%Prev: 1.9% | 794,507 SH | Increased+139,577 SH |
| TAYSHA GENE THERAPIES INC | COM | $6.5M | 0.9%Prev: 0.8% | 1,183,195 SH | Increased-62,838 SH |
| TRAVERE THERAPEUTICS INC | COM SHS | $4.2M | 0.6%Prev: 0.5% | 110,719 SH | Increased |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $10.6M | 1.5%Prev: 2.1% | 461,294 SH | Decreased+91,763 SH |
| UNITED THERAPEUTICS CORP | COM | $28.4M | 3.9%Prev: 4.5% | 58,186 SH | Increased |
| UROGEN PHARMA LTD | COM | $574K | 0.1%Prev: 0.1% | 24,500 SH | Increased |
| XENON PHARMACEUTICALS INC | COM | $4.3M | 0.6% | 96,519 SH | New |