Business Description

Overview and Strategy Powering the Immune System to Transform Lives. Vir Biotechnology, Inc. (including its subsidiaries, referred to as “Vir Bio,” “the Company,” “we,” “our” or “us”) is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. These diseases represent formidable challenges to human health. Under normal conditions, our immune system is naturally equipped to protect us by identifying and eradicating both cancer cells and viruses. However, these threats have evolved sophisticated mechanisms to evade our immune defenses. When cancer cells or viruses successfully bypass our immune system, they have the potential to cause diseases that may be life-threatening. We are focused on developing therapies that enhance the immune system’s ability to overcome these evasion tactics, effectively powering the immune system to combat viruses and fight cancer. We believe our unified approach of leveraging our deep understanding of immunology to address seemingly disparate threats distinguishes us in the field. Our mission is to develop innovative therapies that can transform patients' lives by addressing areas of high unmet medical need. Our clinical development pipeline consists of investigational therapies targeting hepatitis delta virus (HDV) and multiple solid tumors. In hepatitis delta, we have initiated our registrational ECLIPSE clinical program evaluating the tobevibart and elebsiran combination in people living with chronic hepatitis delta (CHD). The three randomized, controlled trials (ECLIPSE 1, 2, and 3) are ongoing, with ECLIPSE 1 and 3 completing enrollment ahead of the Company’s expectations. Topline results from ECLIPSE 1 are expected in the fourth quarter of 2026 with topline results from ECLIPSE 2 and 3 expected in the first quarter of 2027. Should the ECLIPSE program yield positive results that support regulatory approval and subsequent commercial launch, we believe the combination has the potential to be a new standard of care for CHD patients, for whom approved treatment options are either limited or unavailable. In oncology, we are advancing three Phase 1 clinical studies of dual-masked T-cell engagers (TCEs): VIR-5500 in patients with Prostate-Specific Membrane Antigen (PSMA)-expressing metastatic castration-resistant prostate cancer (mCRPC); VIR-5818 in patients with HER2-expressing tumors; and VIR-5525 in patients with EGFR-expressing tumors. We are developing therapeutic candidates in HIV cure and multiple solid tumors. Our HIV broadly neutralizing antibodies (bnAbs) are being developed as a potential long-acting treatment or cure in combination with existing or investigational regimens. We have also made available for external partnerships our next-generation preclinical influenza A and B antibodies and antibody drug conjugates (ADCs), along with our next generation coronavirus (COVID) monoclonal antibodies. We are advancing multiple undisclosed PRO-XTEN ® dual-masked TCEs targeting clinically validated targets with potential applications across a variety of solid tumors. These preclinical candidates leverage the PRO-XTEN ® masking technology with novel TCE fragments discovered and engineered using our antibody discovery platform. These research and development efforts are driven by Vir Bio’s discovery engine, comprised of our exceptional protein engineering and antibody discovery expertise and our two core technology platforms — our proprietary dAIsY™ (data, AI structure and antibodY) platform utilizing artificial intelligence and machine learning (collectively referred to as AI) for antibody optimization, and the exclusive PRO-XTEN ® (a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company) masking platform, which we in-licensed from Sanofi for worldwide rights in oncology and infectious diseases. The PRO-XTEN ® platform allows for the development of potentially best-in-class TCEs with improved safety and efficacy profiles across multiple therapeutic areas. The dAIsY™ and PRO-XTEN ® platforms, individually and in combination, enable us to modulate the immune system in innovative ways, harnessing its power to combat viruses and fight cancer.…