Business Description

Overview We are a medical technology company focused on (i) diagnostic, ablation and deep brain stimulation technology for brain related conditions such as epilepsy and Parkinson’s disease; (ii) ablation and stimulation for pain management throughout the body; and (iii) drug delivery including diagnostic and stimulation capabilities. We have received 510(k) clearance for four of our devices from the Food and Drug Administration (“FDA”), including: (i) our Evo cortical electrode technology for temporary (less than 30 days) recording, monitoring, and stimulation on the surface of the brain (“Evo Cortical”), (ii) our Evo sEEG electrode technology for temporary (less than 30 days) use with recording, monitoring, and stimulation equipment for the recording, monitoring, and stimulation of electrical signals at the subsurface level of the brain (“Evo sEEG”), (iii) our OneRF ablation system for creation of radiofrequency lesions in nervous tissue for functional neurosurgical procedures (“OneRF Brain Ablation System”), and (iv) our OneRF TN ablation system for use in procedures to create radiofrequency lesions for the treatment of pain, or for lesioning nerve tissue for functional neurosurgical procedures (“OneRF TN Ablation System”). We have a distribution agreement with Zimmer, Inc. (“Zimmer”) providing Zimmer Biomet Holdings, Inc. with a license to commercialize and distribute the Evo Cortical, Evo sEEG, and OneRF Brain Ablation System in the brain. We initiated a limited market release of the OneRF TN Ablation System in December 2025. The Company’s other products and indications are still under development. Products We are focused on developing thin film electrode technology for a variety of recording and therapeutic applications. These cortical sheet and depth electrode technologies are crucial for diagnosing neurological disorders such as epilepsy, Parkinson’s disease, dystonia, essential tremors, and other related conditions. Commercialized Products ● Evo ® Cortical : Cortical or subdural electrodes are used in intracranial electroencephalography (iEEG) surgeries to monitor, record and stimulate the surface of the brain for less than 30 days. Our Evo cortical electrode portfolio consists of various contact configurations of strip and grid electrodes. ● Evo sEEG : Evo® sEEG Electrode technology for temporary (less than 30 days) use with recording, monitoring, and stimulation equipment for the recording, monitoring, and stimulation of electrical signals at the subsurface level of the brain. Federal (USA) law restricts this device to sale by or on the order of a physician. Evo sEEG enhances the ability to identify the right foci zones to determine the best intervention for patients. ● OneRF ® Brain Ablation System : Our OneRF Brain Ablation System is indicated for creation of radiofrequency lesions in nervous tissue for functional neurosurgical procedures. It provides bedside monitoring, mapping and ablation using the same device, giving physicians a less invasive, potentially safer way to gain improved bedside clarity of the therapeutic window for an epilepsy patient with the possibility of seizure reduction or freedom. ● OneRF ® TN Ablation System : Our OneRF® Trigeminal Nerve Ablation System is indicated for use in procedures to create radiofrequency lesions for the treatment of pain, or for lesioning nerve tissue for functional neurosurgical procedures. Differentiated features of this system include a “first-of-its-kind” multi-contact RF probe that allows for both precise localization and tailored ablation of the pain-conducting nerve tissue – using the same RF probe, and under temperature-controlled conditions which enhance safety and accuracy. This system may allow for reduced procedural time, improved patient comfort and improved patient safety. 1 NeuroOne Medical Technologies Corporation FORM 10-K Products in Development Drug delivery including diagnostic and stimulation capabilities ● Drug delivery : We are also researching and developing the capability to create a new type of combination device based on our sEEG electrode technology to deliver drugs or gene or cell therapies while having the ability to record brain activity before, during, and after delivery.…