| ABEONA THERAPEUTICS INC | COM NEW | $5.3M | 0.3% | 1,000,000 SH | New |
| ACADIA PHARMACEUTICALS INC | COM | $8.0M | 0.4%Prev: 1.2% | 300,000 SH | Decreased-1,200,000 SH |
| ADICET BIO INC | COM NEW | $52K | 0.0% | 6,158 SH | New |
| ALEXANDRIA REAL ESTATE EQ IN | COM | $2.0M | 0.1%Prev: 0.1% | 40,000 SH | Decreased |
| ALTIMMUNE INC | COM NEW | $7.7M | 0.4%Prev: 0.3% | 2,131,307 SH | Decreased |
| ANAPTYSBIO INC | COM | $64.6M | 3.2%Prev: 1.6% | 1,332,087 SH | Increased-1,552 SH |
| ANI PHARMACEUTICALS INC | COM | $38.0M | 1.9%Prev: 1.1% | 481,437 SH | Increased+163,937 SH |
| ARVINAS INC | COM | $6.8M | 0.3%Prev: 0.5% | 569,698 SH | Decreased-824,102 SH |
| ATEA PHARMACEUTICALS INC | COM | $17.2M | 0.8%Prev: 0.5% | 4,814,700 SH | Increased-11,500 SH |
| AURINIA PHARMACEUTICALS INC | COM | $180.7M | 8.9%Prev: 4.8% | 11,329,500 SH | Increased |
| AVIDITY BIOSCIENCES INC | COM | $64.9M | 3.2% | 900,000 SH | New |
| BIOCRYST PHARMACEUTICALS INC | COM | $6.2M | 0.3%Prev: 0.2% | 800,000 SH | Increased |
| BIOGEN INC | COM | $6.2M | 0.3%Prev: 0.2% | 35,000 SH | Increased |
| BIOHAVEN LTD | COM | $1.6M | 0.1%Prev: 0.1% | 140,000 SH | Decreased |
| BIONTECH SE | SPONSORED ADS | $44.7M | 2.2%Prev: 1.0% | 470,000 SH | Increased+200,000 SH |
| BRISTOL-MYERS SQUIBB CO | COM | $10.8M | 0.5% | 200,000 SH | New |
| CAPRICOR THERAPEUTICS INC | COM NEW | $49.1M | 2.4% | 1,700,000 SH | New |
| CASSAVA SCIENCES INC | COM | $14K | 0.0% | 7,073 SH | New |
| CELCUITY INC | COM | $104.7M | 5.2%Prev: 2.2% | 1,050,000 SH | Increased-100,000 SH |
| COHERUS ONCOLOGY INC | COM | $3.9M | 0.2%Prev: 0.3% | 2,724,509 SH | Decreased-2,372,853 SH |
| COMPASS THERAPEUTICS INC | COM | $90.2M | 4.5%Prev: 2.3% | 16,790,809 SH | Increased-21,154 SH |
| CORCEPT THERAPEUTICS INC | COM | $5.5M | 0.3% | 156,764 SH | New |
| CRESCENT BIOPHARMA INC. | COM | $10.3M | 0.5%Prev: 0.3% | 872,398 SH | Increased+192,574 SH |
| DIANTHUS THERAPEUTICS INC | COM | $10.9M | 0.5%Prev: 0.4% | 264,692 SH | Increased |
| DYNAVAX TECHNOLOGIES CORP | COM NEW | $8.6M | 0.4%Prev: 0.7% | 556,359 SH | Decreased-1,393,141 SH |
| ERASCA INC | COM | $3.3M | 0.2%Prev: 0.1% | 900,000 SH | Increased-602,915 SH |
| EVOLUS INC | COM | $8.3M | 0.4%Prev: 1.3% | 1,245,692 SH | Decreased-4,242,607 SH |
| FATE THERAPEUTICS INC | COM | $1.1M | 0.1%Prev: 0.1% | 1,167,773 SH | Decreased-700,000 SH |
| GALAPAGOS NV | SPON ADR | $128.2M | 6.3%Prev: 5.5% | 3,921,219 SH | Decreased-229,975 SH |
| GSK PLC | SPONSORED ADR | $14.7M | 0.7%Prev: 0.7% | 300,000 SH | Decreased-100,000 SH |
| HARMONY BIOSCIENCES HLDGS IN | COM | $10.9M | 0.5%Prev: 0.3% | 290,292 SH | Increased+9,092 SH |
| HERON THERAPEUTICS INC | COM | $8.1M | 0.4%Prev: 0.2% | 6,250,000 SH | Increased+2,800,000 SH |
| IDEAYA BIOSCIENCES INC | COM | $15.6M | 0.8%Prev: 0.4% | 450,000 SH | Increased+50,000 SH |
| IMMUNITYBIO INC | COM | $4.6M | 0.2%Prev: 0.2% | 2,333,333 SH | Decreased |
| IMMUNOCORE HLDGS PLC | ADS | $91.2M | 4.5%Prev: 3.2% | 2,628,538 SH | Increased+322,930 SH |
| INSMED INC | COM PAR $.01 | $10.4M | 0.5%Prev: 1.1% | 60,000 SH | Decreased-140,000 SH |
| JOURNEY MED CORP | COM | $14.3M | 0.7%Prev: 0.5% | 1,854,596 SH | Increased |
| KALVISTA PHARMACEUTICALS INC | COM | $73.9M | 3.6%Prev: 2.4% | 4,573,530 SH | Increased-468,268 SH |
| KEZAR LIFE SCIENCES INC | COM NEW | $4.2M | 0.2%Prev: 0.1% | 664,314 SH | Increased-55,686 SH |
| KINIKSA PHARMACEUTICALS INTL | ORD SHS CL A | $93.2M | 4.6%Prev: 3.5% | 2,259,889 SH | Increased-68,720 SH |
| LENZ THERAPEUTICS INC | COM | $13.8M | 0.7%Prev: 1.6% | 865,169 SH | Decreased-32,447 SH |
| META PLATFORMS INC | CL A | $15.4M | 0.8%Prev: 0.7% | 23,331 SH | Decreased-2,677 SH |
| MIRUM PHARMACEUTICALS INC | COM | $97.6M | 4.8%Prev: 3.5% | 1,236,027 SH | Increased |
| MODERNA INC | COM | $20.4M | 1.0%Prev: 0.3% | 692,820 SH | Increased+387,520 SH |
| NEUMORA THERAPEUTICS INC. | COM | $1.7M | 0.1% | 967,235 SH | New |
| NKARTA INC | COM | $2.7M | 0.1%Prev: 0.6% | 1,480,823 SH | Decreased-5,574,753 SH |
| NUVALENT INC | COM | $2.2M | 0.1%Prev: 0.2% | 21,880 SH | Decreased-28,120 SH |
| NUVATION BIO INC | COM CL A | $34.6M | 1.7%Prev: 0.6% | 3,857,457 SH | Increased-342,543 SH |
| NVIDIA CORPORATION | COM | $23.8M | 1.2%Prev: 0.9% | 127,788 SH | Decreased-2,721 SH |
| PLIANT THERAPEUTICS INC | COM | $7.5M | 0.4%Prev: 0.3% | 6,143,132 SH | Decreased+139,686 SH |
| PMV PHARMACEUTICALS INC | COM | $6.2M | 0.3% | 4,940,000 SH | New |
| PRECIGEN INC | COM | $23.5M | 1.2%Prev: 1.6% | 5,617,500 SH | Decreased-6,782,500 SH |
| PTC THERAPEUTICS INC | COM | $113.9M | 5.6%Prev: 3.5% | 1,500,000 SH | Increased |
| REGENERON PHARMACEUTICALS | COM | $6.2M | 0.3%Prev: 0.2% | 8,000 SH | Increased-2,000 SH |
| REVOLUTION MEDICINES INC | COM | $1.2M | 0.1%Prev: 0.2% | 15,640 SH | Decreased-84,360 SH |
| ROCKET PHARMACEUTICALS INC | COM | $351K | 0.0%Prev: 0.1% | 100,000 SH | Decreased-750,000 SH |
| SAREPTA THERAPEUTICS INC | COM | $7.5M | 0.4%Prev: 0.4% | 349,220 SH | Decreased-250,780 SH |
| SPDR S&P 500 ETF TR | TR UNIT | $20.5M | 1.0% | 30,000 SH | New |
| SPYRE THERAPEUTICS INC | COM NEW | $62.0M | 3.1%Prev: 2.1% | 1,892,200 SH | Increased-1,307,800 SH |
| STOKE THERAPEUTICS INC | COM | $15.9M | 0.8%Prev: 0.5% | 500,000 SH | Increased |
| SUTRO BIOPHARMA INC | COM SHS | $1.6M | 0.1% | 139,617 SH | New |
| TARSUS PHARMACEUTICALS INC | COM | $97.3M | 4.8%Prev: 5.6% | 1,188,624 SH | Decreased-1,266,173 SH |
| TELADOC HEALTH INC | COM | $9.8M | 0.5%Prev: 0.4% | 1,400,000 SH | Decreased |
| THERAVANCE BIOPHARMA INC | COM | $6.6M | 0.3%Prev: 0.1% | 351,252 SH | Increased+86,944 SH |
| TRAVERE THERAPEUTICS INC | COM | $26.7M | 1.3%Prev: 0.6% | 700,000 SH | Increased |
| TSCAN THERAPEUTICS INC | COM | $46K | 0.0%Prev: 0.0% | 46,131 SH | Decreased-553,869 SH |
| UROGEN PHARMA LTD | COM | $8.2M | 0.4%Prev: 0.8% | 350,000 SH | Decreased-650,000 SH |
| VAXCYTE INC | COM | $12.7M | 0.6%Prev: 0.4% | 275,000 SH | Increased-25,000 SH |
| VENTYX BIOSCIENCES INC | COM | $25.4M | 1.3%Prev: 0.4% | 2,814,000 SH | Increased-286,000 SH |
| VERASTEM INC | COM NEW | $8.3M | 0.4%Prev: 0.3% | 1,069,810 SH | Increased+280,000 SH |
| VERTEX PHARMACEUTICALS INC | COM | $36.3M | 1.8%Prev: 1.2% | 80,000 SH | Increased |
| VIKING THERAPEUTICS INC | COM | $17.6M | 0.9%Prev: 0.9% | 500,000 SH | Decreased-370,000 SH |
| VIRIDIAN THERAPEUTICS INC | COM | $55.8M | 2.8%Prev: 2.4% | 1,792,626 SH | Decreased-1,050,299 SH |
| WAVE LIFE SCIENCES LTD | SHS | $10.2M | 0.5% | 600,000 SH | New |
| ZYMEWORKS INC | COM | $912K | 0.0%Prev: 0.7% | 34,631 SH | Decreased-1,065,369 SH |