| ABBVIE INC | COM | $2.1M | 0.4% | 9,325 SH | New |
| ABIVAX SA | SPONSORED ADS | $52.8M | 9.1%Prev: 2.8% | 391,783 SH | Increased+225,510 SH |
| ADAPTIVE BIOTECHNOLOGIES COR | COM | $9.9M | 1.7% | 606,825 SH | New |
| ADC THERAPEUTICS SA | SHS | $1.8M | 0.3%Prev: 0.2% | 502,570 SH | Increased+219,284 SH |
| AMYLYX PHARMACEUTICALS INC | COM | $6.8M | 1.2%Prev: 0.8% | 565,140 SH | Increased+288,256 SH |
| APOGEE THERAPEUTICS INC | COM | $6.1M | 1.0% | 80,574 SH | New |
| ARBUTUS BIOPHARMA CORP | COM | $4.7M | 0.8%Prev: 0.2% | 986,751 SH | Increased+686,363 SH |
| ARCELLX INC | COMMON STOCK | $21.7M | 3.7%Prev: 0.2% | 332,860 SH | Increased+321,484 SH |
| ARCUTIS BIOTHERAPEUTICS INC | COM | $6.5M | 1.1%Prev: 1.6% | 224,740 SH | Decreased-187,153 SH |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $3.2M | 0.5%Prev: 0.6% | 14,842 SH | Increased-307 SH |
| ASSEMBLY BIOSCIENCES INC | COM NEW | $5.3M | 0.9%Prev: 0.3% | 156,728 SH | Increased+90,598 SH |
| AVALO THERAPEUTICS INC | COM NEW | $2.5M | 0.4% | 135,552 SH | New |
| BELITE BIO INC | SPONSORED ADS | $1.5M | 0.3% | 9,163 SH | New |
| BRIDGEBIO ONCOLOGY THERAPEUT | COM NEW | $1.1M | 0.2%Prev: 0.4% | 86,517 SH | Decreased-100,097 SH |
| BRIGHT MINDS BIOSCIENCES INC | COM NEW | $7.6M | 1.3% | 97,340 SH | New |
| CAPRICOR THERAPEUTICS INC | COM NEW | $515K | 0.1% | 17,853 SH | New |
| CELCUITY INC | COM | $11.8M | 2.0%Prev: 1.4% | 118,333 SH | Increased-18,377 SH |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $28.9M | 5.0%Prev: 3.4% | 1,229,114 SH | Increased+401,229 SH |
| CLEARPOINT NEURO INC | COM | $6.6M | 1.1%Prev: 0.1% | 481,858 SH | Increased+465,207 SH |
| CYTOKINETICS INC | COM NEW | $9.3M | 1.6% | 146,978 SH | New |
| CYTOMX THERAPEUTICS INC | COM | $4.4M | 0.8% | 1,036,311 SH | New |
| DENALI THERAPEUTICS INC | COM | $6.9M | 1.2%Prev: 5.0% | 419,058 SH | Decreased-1,315,601 SH |
| DIANTHUS THERAPEUTICS INC | COM | $3.3M | 0.6%Prev: 0.3% | 79,284 SH | Increased+37,902 SH |
| DYNE THERAPEUTICS INC | COM | $16.3M | 2.8%Prev: 1.2% | 835,200 SH | Increased+360,588 SH |
| EDGEWISE THERAPEUTICS INC | COM | $9.0M | 1.5% | 360,876 SH | New |
| ELI LILLY & CO | COM | $5.1M | 0.9% | 4,759 SH | New |
| EVOMMUNE INC | COM SHS | $1.2M | 0.2% | 68,196 SH | New |
| EYEPOINT INC | COM NEW | $6.5M | 1.1% | 353,849 SH | New |
| IDEAYA BIOSCIENCES INC | COM | $5.6M | 1.0%Prev: 2.0% | 161,659 SH | Decreased-210,166 SH |
| IMMATICS N.V | SHS | $6.4M | 1.1% | 610,308 SH | New |
| IMMUNOVANT INC | COM | $16.4M | 2.8%Prev: 5.1% | 644,959 SH | Decreased-1,194,621 SH |
| INCYTE CORP | COM | $6.1M | 1.0%Prev: 0.7% | 61,435 SH | Increased+17,681 SH |
| INVENTIVA SA | ADS | $2.2M | 0.4%Prev: 0.0% | 467,242 SH | Increased+436,418 SH |
| INVIVYD INC | COM | $2.4M | 0.4%Prev: 0.1% | 989,822 SH | Increased+711,214 SH |
| JOHNSON & JOHNSON | COM | $7.2M | 1.2% | 35,000 SH | New |
| LEGEND BIOTECH CORP | SPONSORED ADS | $1.6M | 0.3% | 73,328 SH | New |
| MADRIGAL PHARMACEUTICALS INC | COM | $10.3M | 1.8%Prev: 0.8% | 17,736 SH | Increased+9,529 SH |
| MAPLIGHT THERAPEUTICS INC | COM | $1.8M | 0.3% | 100,000 SH | New |
| MAZE THERAPEUTICS INC | COM | $5.2M | 0.9% | 125,877 SH | New |
| MBX BIOSCIENCES INC | COM | $2.5M | 0.4%Prev: 0.3% | 78,553 SH | Increased+3,553 SH |
| MEIRAGTX HLDGS PLC | COM | $2.3M | 0.4%Prev: 0.1% | 287,689 SH | Increased+205,831 SH |
| MINERALYS THERAPEUTICS INC | COM | $10.5M | 1.8%Prev: 1.2% | 290,049 SH | Increased+131,937 SH |
| MONTE ROSA THERAPEUTICS INC | COM | $966K | 0.2% | 61,577 SH | New |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | $4.6M | 0.8% | 348,401 SH | New |
| NEKTAR THERAPEUTICS | COM NEW | $7.5M | 1.3%Prev: 0.6% | 178,274 SH | Increased+125,073 SH |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | $2.6M | 0.4%Prev: 0.9% | 73,106 SH | Decreased-77,467 SH |
| OCULAR THERAPEUTIX INC | COM | $6.3M | 1.1%Prev: 0.8% | 522,693 SH | Increased+163,223 SH |
| PALISADE BIO INC | COM | $9.9M | 1.7% | 4,192,375 SH | New |
| PASITHEA THERAPEUTICS CORP | COM NEW | $458K | 0.1% | 355,082 SH | New |
| PHARVARIS N V | COM | $1.6M | 0.3% | 58,389 SH | New |
| PRAXIS PRECISION MEDICINES I | COM NEW | $6.2M | 1.1% | 21,067 SH | New |
| PROTAGONIST THERAPEUTICS INC | COM | $5.2M | 0.9%Prev: 0.6% | 59,430 SH | Increased+11,476 SH |
| QUINCE THERAPEUTICS INC | COM | $2.5M | 0.4% | 739,264 SH | New |
| REPLIGEN CORP | COM | $2.6M | 0.4% | 15,707 SH | New |
| REVOLUTION MEDICINES INC | COM | $4.9M | 0.8%Prev: 1.7% | 62,032 SH | Decreased-123,348 SH |
| RHYTHM PHARMACEUTICALS INC | COM | $6.3M | 1.1%Prev: 1.9% | 58,915 SH | Decreased-32,529 SH |
| ROIVANT SCIENCES LTD | SHS | $21.0M | 3.6%Prev: 12.7% | 966,698 SH | Decreased-3,230,489 SH |
| SAB BIOTHERAPEUTICS INC | COM NEW | $548K | 0.1% | 146,558 SH | New |
| SCHOLAR ROCK HLDG CORP | COM | $39.6M | 6.8%Prev: 5.4% | 1,163,893 SH | Increased+419,289 SH |
| SPYRE THERAPEUTICS INC | COM NEW | $1.1M | 0.2% | 32,377 SH | New |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $24.4M | 4.2%Prev: 0.7% | 351,073 SH | Increased+221,738 SH |
| SURROZEN INC | COM NEW | $12.7M | 2.2%Prev: 1.8% | 619,766 SH | Increased-93,697 SH |
| SYNDAX PHARMACEUTICALS INC | COM | $28.1M | 4.8%Prev: 4.2% | 1,339,379 SH | Increased-126,826 SH |
| TAYSHA GENE THERAPIES INC | COM SHS | $1.0M | 0.2%Prev: 0.6% | 182,130 SH | Decreased-657,539 SH |
| TERNS PHARMACEUTICALS INC | COM | $17.3M | 3.0%Prev: 0.1% | 429,198 SH | Increased+339,581 SH |
| TREVI THERAPEUTICS INC | COM | $5.0M | 0.9%Prev: 0.6% | 399,557 SH | Increased+48,847 SH |
| TWIST BIOSCIENCE CORP | COM | $16.4M | 2.8% | 518,355 SH | New |
| UNIQURE NV | SHS | $1.0M | 0.2%Prev: 6.1% | 43,485 SH | Decreased-478,670 SH |
| VANDA PHARMACEUTICALS INC | COM | $520K | 0.1% | 58,989 SH | New |
| VIRIDIAN THERAPEUTICS INC | COM | $4.8M | 0.8% | 154,320 SH | New |
| VISTAGEN THERAPEUTICS INC | COM | $142K | 0.0%Prev: 1.6% | 616,749 SH | Decreased-1,871,936 SH |
| WHITEHAWK THERAPEUTICS INC | COM | $3.5M | 0.6%Prev: 0.2% | 1,458,807 SH | Increased+1,034,725 SH |
| X4 PHARMACEUTICALS INC | COM NEW | $3.6M | 0.6%Prev: 0.4% | 898,465 SH | Increased+343,054 SH |
| XENON PHARMACEUTICALS INC | COM | $15.6M | 2.7%Prev: 1.5% | 348,605 SH | Increased+156,310 SH |
| XILIO THERAPEUTICS INC | COM | $1.3M | 0.2% | 2,030,028 SH | New |