Siren, L.L.C.

CIK 0002005245 • 7 13F filings • May 14, 2025 – Aug 13, 2026

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Filer information

Filed by: Siren, L.L.C., President
Address: The Invus Group, Llc, 750 Lexington Avenue, 30th Floor, New York, NY, 10022
Phone: 212-371-1717
AUM: $3.35B

AUM over time

$4.94B latest

Sector allocation over time

Past 5 quarters

Q4 2025

Q3 2025

Q2 2026

Q2 2025

Q1 2026

TechnologyHealthcareConsumer DiscretionaryEnergyOther

Holdings by filing

Portfolio value: $3.35B2 positionsView on SEC.gov

			% of Portfolio
Adobe Inc	COM	$4.2M	0.1%Prev: 0.2%	12,051 SH	Decreased-3,000 SH
Agenus Inc	COM NEW	$3.3M	0.1%Prev: 0.2%	1,064,250 SH	Decreased
Alphabet Inc	CAP STK CL A	$6.5M	0.2%Prev: 0.2%	20,703 SH	Increased-500 SH
Alumis Inc	COM	$4.9M	0.1%	500,000 SH	New
Amazon.com Inc	COM	$11.9M	0.4%Prev: 0.5%	51,500 SH	Decreased-7,000 SH
Apellis Pharmaceuticals Inc	COM	$64.8M	1.9%Prev: 2.3%	2,578,396 SH	Increased
Arcus Biosciences Inc	COM	$71.7M	2.1%Prev: 1.5%	3,007,077 SH	Increased+95,000 SH
Arm Holdings PLC	SPONSORED ADS	$2.4M	0.1%	21,500 SH	New
Arrowhead Pharmaceuticals Inc	COM	$99.6M	3.0%Prev: 3.6%	1,500,476 SH	Increased-1,169,404 SH
Ascendis Pharma A/S	SPONSORED ADR	$50.3M	1.5%Prev: 1.8%	235,862 SH	Increased
Benitec Biopharma Inc	COM NEW	$10.4M	0.3%	775,000 SH	New
BeOne Medicines AG	SPONSORED ADS	$151.9M	4.5%Prev: 6.6%	500,000 SH	Decreased+7,010 SH
Bicara Therapeutics Inc	COM	$87.8M	2.6%Prev: 3.2%	5,216,969 SH	Increased
Bicycle Therapeutics PLC	SPONSORED ADS	$14.3M	0.4%Prev: 0.6%	2,012,752 SH	Decreased
BillionToOne Inc	CL A	$6.9M	0.2%	83,833 SH	New
Black Diamond Therapeutics Inc	COM	$2.5M	0.1%Prev: 0.2%	1,046,517 SH	Decreased
Broadcom Inc	COM	$2.4M	0.1%	7,000 SH	New
Caribou Biosciences Inc	COM	$168K	0.0%Prev: 0.0%	105,347 SH	Decreased
Cellebrite DI Ltd	ORDINARY SHARES	$2.7M	0.1%Prev: 0.1%	150,000 SH	Increased+60,000 SH
Centessa Pharmaceuticals PLC	SPONSORED ADS	$100.7M	3.0%Prev: 3.1%	4,027,517 SH	Increased+800,000 SH
Cogent Biosciences Inc	COM	$57.9M	1.7%Prev: 1.0%	1,629,279 SH	Increased-95,000 SH
Compass Pathways PLC	SPONSORED ADS	$6.9M	0.2%	1,000,000 SH	New
CoreWeave Inc	COM CL A	$2.0M	0.1%Prev: 0.1%	27,500 SH	Decreased+3,500 SH
Crinetics Pharmaceuticals Inc	COM	$70.2M	2.1%Prev: 2.8%	1,507,636 SH	Decreased-180,975 SH
CrowdStrike Holdings Inc	CL A	$7.7M	0.2%Prev: 0.4%	16,500 SH	Decreased-2,000 SH
Cullinan Therapeutics Inc	COM	$12.4M	0.4%Prev: 0.3%	1,193,410 SH	Increased
Cyclerion Therapeutics Inc	COM	$147K	0.0%Prev: 0.0%	115,603 SH	Decreased-552 SH
Datadog Inc	CL A COM	$5.0M	0.1%Prev: 0.2%	36,425 SH	Increased+3,500 SH
Dbv Technologies SA	SPONSORED ADS	$35.6M	1.1%	1,857,362 SH	New
Denali Therapeutics Inc	COM	$23.1M	0.7%Prev: 0.5%	1,396,513 SH	Increased+575,000 SH
Disc Medicine Inc	COM	$78.5M	2.3%Prev: 2.4%	988,401 SH	Increased+75,000 SH
Dynatrace Inc	COM NEW	$5.0M	0.1%Prev: 0.2%	115,229 SH	Increased+15,000 SH
Dyne Therapeutics Inc	COM	$68.5M	2.0%Prev: 2.3%	3,502,941 SH	Increased-1,226,233 SH
Edgewise Therapeutics Inc	COM	$112.4M	3.4%Prev: 2.5%	4,529,990 SH	Increased+632,891 SH
enGene Holdings Inc	COM	$30.1M	0.9%	3,336,264 SH	New
Erasca Inc	COM	$32.6M	1.0%Prev: 0.7%	8,757,249 SH	Increased
Figma Inc	CLASS A COM STK	$934K	0.0%Prev: 0.0%	25,000 SH	Increased+10,000 SH
Foghorn Therapeutics Inc	COM	$3.9M	0.1%Prev: 0.1%	720,720 SH	Increased
Fulcrum Therapeutics Inc	COM	$22.1M	0.7%	1,950,000 SH	New
Generation Bio Inc	COM NEW	$1.1M	0.0%	201,419 SH	New
GitLab Inc	CLASS A COM	$3.7M	0.1%Prev: 0.1%	99,000 SH	Increased+35,000 SH
Gossamer Bio Inc	COM	$16.1M	0.5%Prev: 0.5%	5,208,968 SH	Increased
IHS Holding Limited	ORD SHS	$17.6M	0.5%Prev: 0.6%	2,357,520 SH	Increased
Inhibikase Therapeutics Inc	COM NEW	$12.0M	0.4%	5,850,000 SH	New
Instil Bio Inc	COM NEW	$2.2M	0.1%Prev: 0.1%	203,933 SH	Decreased
Invivyd Inc	COM	$9.9M	0.3%	4,000,000 SH	New
IONQ Inc	COM	$7.6M	0.2%Prev: 0.4%	170,000 SH	Decreased
IREN Ltd	ORDINARY SHARES	$1.6M	0.0%Prev: 0.0%	43,100 SH	Increased+23,100 SH
Jfrog Ltd	ORD SHS	$5.8M	0.2%Prev: 0.2%	93,616 SH	Increased-13,500 SH
Kalaris Therapeutics Inc	COM	$3.7M	0.1%Prev: 0.1%	435,798 SH	Increased+117,534 SH
Ke Holdings Inc	SPONSORED ADS	$2.3M	0.1%Prev: 0.1%	145,000 SH	Decreased
Korro Bio Inc	COM	$2.8M	0.1%Prev: 0.8%	347,718 SH	Decreased-71,115 SH
Kymera Therapeutics Inc	COM	$255.7M	7.6%Prev: 7.6%	3,286,830 SH	Increased-141,320 SH
Lexeo Therapeutics Inc	COM	$7.2M	0.2%Prev: 0.2%	720,622 SH	Increased+117,187 SH
Lexicon Pharmaceuticals Inc	COM NEW	$44.8M	1.3%Prev: 2.1%	38,918,903 SH	Decreased
MapLight Therapeutics Inc	COM	$7.9M	0.2%	450,000 SH	New
Medline Inc	COM CL A	$3.1M	0.1%	75,000 SH	New
Meta Platforms Inc	CL A	$4.7M	0.1%	7,169 SH	New
Microsoft Corp	COM	$7.3M	0.2%Prev: 0.3%	15,000 SH	Decreased-2,150 SH
Mind Medicine (MindMed) Inc	COM NEW	$10.7M	0.3%	800,000 SH	New
Mineralys Therapeutics Inc	COM	$25.4M	0.8%	699,999 SH	New
monday.com Ltd	SHS	$2.5M	0.1%Prev: 0.1%	17,000 SH	Increased+10,000 SH
Monopar Therapeutics Inc	COM NEW	$13.9M	0.4%	212,298 SH	New
Nebius Group NV	SHS CLASS A	$6.4M	0.2%Prev: 0.3%	76,218 SH	Decreased+3,618 SH
Neumora Therapeutics Inc	COM	$11.3M	0.3%Prev: 0.3%	6,288,783 SH	Increased+1,930,500 SH
New Oriental Education & Technology Group Inc	SPON ADR	$3.4M	0.1%Prev: 0.1%	62,000 SH	Increased
NovaBridge Biosciences	SPONSORED ADS	$11.9M	0.4%	3,000,000 SH	New
NVIDIA Corp	COM	$7.0M	0.2%Prev: 0.3%	37,485 SH	Decreased
Olema Pharmaceuticals Inc	COM	$82.5M	2.5%	3,300,700 SH	New
Oric Pharmaceuticals Inc	COM	$8.2M	0.2%Prev: 0.5%	1,007,575 SH	Decreased
Palo Alto Networks Inc	COM	$2.1M	0.1%Prev: 0.1%	11,450 SH	Decreased-2,000 SH
Palvella Therapeutics Inc	COM	$7.9M	0.2%	75,000 SH	New
PDD Holdings Inc	SPONSORED ADS	$7.2M	0.2%Prev: 0.2%	63,401 SH	Increased+20,000 SH
PepGen Inc	COM	$4.6M	0.1%Prev: 0.1%	700,000 SH	Increased
Primo Brands Corp	CLASS A COM SHS	$1.2M	0.0%Prev: 0.1%	75,000 SH	Decreased
Qualcomm Inc	COM	$2.4M	0.1%Prev: 0.1%	14,000 SH	Increased
Rani Therapeutics Holdings Inc	COM CL A	$2.7M	0.1%	2,000,000 SH	New
Rapport Therapeutics Inc	COM	$21.5M	0.6%Prev: 1.2%	708,469 SH	Decreased-345,000 SH
RAPT Therapeutics Inc	COM NEW	$46.6M	1.4%Prev: 0.6%	1,375,000 SH	Increased+794,534 SH
Remitly Global Inc	COM	$22.3M	0.7%Prev: 1.0%	1,618,271 SH	Decreased
Revolution Medicines Inc	COM	$106.3M	3.2%Prev: 1.9%	1,335,075 SH	Increased+291,355 SH
Rhythm Pharmaceuticals Inc	COM	$53.5M	1.6%Prev: 2.0%	499,975 SH	Increased
Sagimet Biosciences Inc	COM SER A	$4.3M	0.1%Prev: 0.2%	724,771 SH	Decreased
Salesforce Inc	COM	$6.9M	0.2%Prev: 0.3%	26,100 SH	Decreased-4,000 SH
Savara Inc	COM	$6.0M	0.2%	1,000,000 SH	New
Scholar Rock Holding Corp	COM	$476.8M	14.2%Prev: 13.5%	10,825,013 SH	Increased+1,575,008 SH
Seer Inc	COM CL A	$7.3M	0.2%Prev: 0.3%	4,000,000 SH	Decreased
Septerna Inc	COM	$55.8M	1.7%Prev: 1.6%	2,000,000 SH	Increased-202,514 SH
ServiceNow Inc	COM	$5.5M	0.2%Prev: 0.3%	35,630 SH	Decreased+28,504 SH
Silence Therapeutics PLC	ADS	$17.7M	0.5%Prev: 0.6%	2,911,438 SH	Increased
Sionna Therapeutics Inc	COM	$12.3M	0.4%Prev: 0.4%	300,000 SH	Increased-25,000 SH
Solid Biosciences Inc	COM NEW	$43.4M	1.3%Prev: 1.8%	7,690,405 SH	Decreased+274,500 SH
Spyre Therapeutics Inc	COM NEW	$26.8M	0.8%Prev: 0.2%	818,598 SH	Increased+450,000 SH
Stoke Therapeutics Inc	COM	$71.3M	2.1%Prev: 2.1%	2,247,347 SH	Increased
Structure Therapeutics Inc	SPONSORED ADS	$75.0M	2.2%Prev: 1.1%	1,078,698 SH	Increased+51,887 SH
Taboola.com Ltd	ORD SHS	$46.0M	1.4%Prev: 1.3%	9,969,495 SH	Increased
Taiwan Semiconductor Manufacturing Co Ltd	SPONSORED ADS	$8.4M	0.3%Prev: 0.3%	27,700 SH	Increased-500 SH
Tango Therapeutics Inc	COM	$72.3M	2.2%Prev: 1.9%	8,165,374 SH	Increased+2,282,186 SH
Taysha Gene Therapies Inc	COM SHS	$55.7M	1.7%Prev: 1.4%	10,129,913 SH	Increased-884,824 SH
Tenax Therapeutics Inc	COM NEW	$5.2M	0.2%Prev: 0.1%	427,141 SH	Increased+74,700 SH
Tesla Inc	COM	$675K	0.0%Prev: 0.0%	1,500 SH	Increased
Trevi Therapeutics Inc	COM	$28.6M	0.9%Prev: 0.9%	2,286,867 SH	Increased-250,000 SH
Upstream Bio Inc	COM	$16.0M	0.5%Prev: 0.6%	588,450 SH	Increased-200,000 SH
Varonis Systems Inc	COM	$1.2M	0.0%	37,500 SH	New
vTv Therapeutics Inc	CL A NEW	$6.5M	0.2%Prev: 0.1%	163,000 SH	Increased
WAVE Life Sciences Ltd	SHS	$41.6M	1.2%Prev: 1.1%	2,450,000 SH	Increased-1,246,322 SH
Whitehawk Therapeutics Inc	COM	$5.0M	0.2%Prev: 0.2%	2,082,000 SH	Increased
Workiva Inc	COM CL A	$6.8M	0.2%Prev: 0.1%	79,123 SH	Increased+49,123 SH
X4 Pharmaceuticals Inc	COM NEW	$6.0M	0.2%	1,500,000 SH	New
Xenon Pharmaceuticals Inc	COM	$36.4M	1.1%Prev: 1.3%	812,761 SH	Increased
Zscaler Inc	COM	$2.7M	0.1%	12,000 SH	New
Zura Bio Ltd	CLASS A ORD SHS	$6.8M	0.2%	1,300,000 SH	New
Zymeworks Inc	COM	$44.2M	1.3%	1,680,121 SH	New

Sold (vs prior filing)

Amer Sports Inc — $869K
Arrivent Biopharma Inc — $12.9M
Astera Labs Inc — $685K
Avidity Biosciences Inc — $56.0M
BIOAGE Labs Inc — $2.2M
Cartesian Therapeutics Inc — $5.8M
CCC Intelligent Solutions Holdings Inc — $456K
Chime Financial Inc — $504K
Chipotle Mexican Grill Inc — $1.9M
Confluent Inc — $743K
Elastic NV — $1.1M
Eledon Pharmaceuticals Inc — $5.4M
Generation Bio Co — $1.8M
HubSpot Inc — $1.9M
I-Mab — $4.4M
Ironwood Pharmaceuticals Inc — $145K
Kenvue Inc — $406K
Keurig Dr Pepper Inc — $2.0M
NewAmsterdam Pharma Company NV — $21.8M
NIQ Global Intelligence PLC — $1.5M
… and 10 more

All filings

Open a filing on Jive Data

Filing Date	Quarter	Form	Accession	Portfolio	Filing
Feb 13, 2026	Q4 2025	13F-HR	0002005245-26-000003	$3.35B	View
Nov 13, 2025	Q3 2025	13F-HR	0002005245-25-000012	$2.56B	View
Aug 13, 2026	Q2 2026