| 4D MOLECULAR THERAPEUTICS IN | COM | $750K | 0.1% | 100,000 SH | New |
| AARDVARK THERAPEUTICS INC | COM | $4.0M | 0.6%Prev: 0.6% | 303,939 SH | Decreased-2,973 SH |
| ABEONA THERAPEUTICS INC | COM NEW | $3.3M | 0.5%Prev: 0.7% | 627,738 SH | Decreased-367,016 SH |
| ABIVAX SA | SPONSORED ADS | $56.9M | 7.9%Prev: 6.2% | 422,193 SH | Increased-117,511 SH |
| ADAGIO MED HLDGS INC | COM | $536K | 0.1% | 515,384 SH | New |
| AMYLYX PHARMACEUTICALS INC | COM | $6.1M | 0.8%Prev: 1.3% | 506,242 SH | Decreased-193,758 SH |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $10.5M | 1.5%Prev: 1.4% | 49,228 SH | Decreased-4,326 SH |
| AVALO THERAPEUTICS INC | COM NEW | $9.5M | 1.3%Prev: 1.2% | 524,436 SH | Increased-196,486 SH |
| BENITEC BIOPHARMA INC | COM NEW | $9.9M | 1.4%Prev: 0.5% | 731,717 SH | Increased+455,450 SH |
| BIOGEN INC | COM | $13.3M | 1.8%Prev: 1.5% | 75,412 SH | Increased-5,007 SH |
| C4 THERAPEUTICS INC | COM STK | $3.8M | 0.5%Prev: 0.6% | 1,994,224 SH | Decreased+96,841 SH |
| CELCUITY INC | COM | $37.4M | 5.2%Prev: 0.6% | 375,132 SH | Increased+286,446 SH |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | $5.2M | 0.7%Prev: 1.2% | 191,074 SH | Decreased-157,848 SH |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $11.5M | 1.6%Prev: 0.5% | 458,203 SH | Increased+316,965 SH |
| CERUS CORP | COM | $5.8M | 0.8%Prev: 0.6% | 2,814,383 SH | Increased+98,597 SH |
| CG ONCOLOGY INC | COM | $15.0M | 2.1%Prev: 3.5% | 361,158 SH | Decreased-277,188 SH |
| COGENT BIOSCIENCES INC | COM | $44.2M | 6.1%Prev: 1.6% | 1,245,254 SH | Increased+430,179 SH |
| COMPASS THERAPEUTICS INC | COM | $5.6M | 0.8%Prev: 1.3% | 1,051,343 SH | Decreased-1,782,645 SH |
| COMPUGEN LTD | ORD | $5.3M | 0.7%Prev: 0.7% | 3,479,805 SH | Increased+168,640 SH |
| CONTINEUM THERAPEUTICS INC | CL A | $3.5M | 0.5%Prev: 0.3% | 307,540 SH | Increased+141,379 SH |
| CYTOMX THERAPEUTICS INC | COM | $1.6M | 0.2% | 385,974 SH | New |
| DIANTHUS THERAPEUTICS INC | COM | $30.9M | 4.3%Prev: 3.6% | 750,136 SH | Increased+75,170 SH |
| EDGEWISE THERAPEUTICS INC | COM | $1.0M | 0.1% | 42,052 SH | New |
| ELUTIA INC | CL A COM | $1.9M | 0.3%Prev: 0.3% | 2,751,314 SH | Decreased-99,673 SH |
| ERASCA INC | COM | $4.9M | 0.7%Prev: 0.4% | 1,317,584 SH | Increased-50,491 SH |
| FRACTYL HEALTH INC | COM | $21.6M | 3.0%Prev: 2.3% | 9,840,041 SH | Increased-759,959 SH |
| FULCRUM THERAPEUTICS INC | CALL | $4.4M | 0.6% | 391,900 SH | New |
| FULCRUM THERAPEUTICS INC | COM | $4.5M | 0.6% | 394,650 SH | New |
| GOSSAMER BIO INC | COM | $6.6M | 0.9%Prev: 1.7% | 2,135,722 SH | Decreased-2,643,360 SH |
| GUARDANT HEALTH INC | COM | $9.4M | 1.3% | 91,914 SH | New |
| IBIO INC | COM NEW | $205K | 0.0% | 106,000 SH | New |
| IMMUNOME INC | COM | $24.2M | 3.4% | 1,126,210 SH | New |
| INSMED INC | COM PAR $.01 | $12.4M | 1.7%Prev: 4.0% | 71,256 SH | Decreased-135,392 SH |
| KALVISTA PHARMACEUTICALS INC | CALL | $4.7M | 0.7% | 290,600 SH | New |
| KALVISTA PHARMACEUTICALS INC | COM | $39.2M | 5.4%Prev: 2.2% | 2,427,118 SH | Increased+1,063,740 SH |
| KODIAK SCIENCES INC | COM | $28.6M | 4.0%Prev: 2.2% | 1,023,122 SH | Increased+23,122 SH |
| KYMERA THERAPEUTICS INC | COM | $2.7M | 0.4% | 34,589 SH | New |
| LEXEO THERAPEUTICS INC | COM | $6.1M | 0.9%Prev: 0.7% | 617,608 SH | Increased-161,003 SH |
| MINERALYS THERAPEUTICS INC | COM | $3.4M | 0.5%Prev: 0.4% | 94,983 SH | Increased+14,983 SH |
| MONTE ROSA THERAPEUTICS INC | COM | $16.1M | 2.2%Prev: 0.7% | 1,029,066 SH | Increased+334,124 SH |
| NEXTCURE INC | COM NEW | $2.5M | 0.3% | 176,057 SH | New |
| NUVALENT INC | COM | $31.3M | 4.4%Prev: 4.3% | 311,430 SH | Decreased-60,870 SH |
| OLEMA PHARMACEUTICALS INC | COM | $5.2M | 0.7%Prev: 1.2% | 206,280 SH | Decreased-727,261 SH |
| ORIC PHARMACEUTICALS INC | COM | $9.1M | 1.3%Prev: 3.2% | 1,116,604 SH | Decreased-832,204 SH |
| PALISADE BIO INC | COM | $240K | 0.0% | 102,108 SH | New |
| PFIZER INC | COM | $10.4M | 1.4% | 419,134 SH | New |
| PRAXIS PRECISION MEDICINES I | COM NEW | $24.3M | 3.4%Prev: 0.4% | 82,465 SH | Increased+31,255 SH |
| RADIOPHARM THERANOSTICS LTD | SPONSORED ADS | $978K | 0.1%Prev: 0.1% | 187,406 SH | Decreased |
| RAPPORT THERAPEUTICS INC | COM | $293K | 0.0%Prev: 0.8% | 9,659 SH | Decreased-194,287 SH |
| RELAY THERAPEUTICS INC | COM | $3.4M | 0.5% | 398,167 SH | New |
| RHYTHM PHARMACEUTICALS INC | COM | $14.6M | 2.0%Prev: 5.0% | 135,950 SH | Decreased-234,046 SH |
| ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | $3K | 0.0%Prev: 0.0% | 104,828 SH | Decreased |
| SIONNA THERAPEUTICS INC | COM | $1.7M | 0.2%Prev: 0.4% | 41,460 SH | Decreased-67,341 SH |
| SOLENO THERAPEUTICS INC | COM | $5.4M | 0.8% | 117,485 SH | New |
| SPYRE THERAPEUTICS INC | COM NEW | $6.2M | 0.9% | 187,737 SH | New |
| SURROZEN INC | COM NEW | $3.6M | 0.5% | 157,323 SH | New |
| SYNDAX PHARMACEUTICALS INC | COM | $13.5M | 1.9%Prev: 1.0% | 642,899 SH | Increased+179,191 SH |
| TARSUS PHARMACEUTICALS INC | COM | $3.0M | 0.4% | 36,124 SH | New |
| TELA BIO INC | COM | $3.1M | 0.4%Prev: 0.6% | 2,647,512 SH | Decreased-135,411 SH |
| TREVI THERAPEUTICS INC | COM | $6.8M | 0.9%Prev: 0.7% | 541,240 SH | Increased-47,549 SH |
| ULTRAGENYX PHARMACEUTICAL IN | CALL | $2.5M | 0.4%Prev: 2.1% | 110,000 SH | Decreased-418,200 SH |
| UNIQURE NV | CALL | $17.2M | 2.4% | 720,800 SH | New |
| UNIQURE NV | SHS | $3.0M | 0.4%Prev: 3.6% | 126,047 SH | Decreased-328,953 SH |
| UROGEN PHARMA LTD | COM | $40.7M | 5.7%Prev: 4.2% | 1,738,821 SH | Increased+161,538 SH |
| VAXCYTE INC | COM | $6.9M | 1.0%Prev: 1.5% | 148,787 SH | Decreased-165,552 SH |
| VERACYTE INC | COM | $15.1M | 2.1%Prev: 1.1% | 357,558 SH | Increased+121,767 SH |
| VIRIDIAN THERAPEUTICS INC | COM | $10.8M | 1.5%Prev: 0.8% | 348,569 SH | Increased+89,060 SH |
| X4 PHARMACEUTICALS INC | COM NEW | $1.4M | 0.2% | 357,387 SH | New |