| 4D MOLECULAR THERAPEUTICS IN | COM | $3.6M | 0.0% | 475,737 SH | New |
| ACADIA PHARMACEUTICALS INC | COM | $190.8M | 1.9%Prev: 1.9% | 7,144,524 SH | Increased |
| ALKERMES PLC | SHS | $46.8M | 0.5%Prev: 0.6% | 1,672,356 SH | Decreased |
| ALLURION TECHNOLOGIES INC | COMMON STOCK | $7.2M | 0.1%Prev: 0.1% | 5,891,430 SH | Increased+3,348,827 SH |
| APELLIS PHARMACEUTICALS INC | COM | $192.6M | 1.9% | 7,666,764 SH | New |
| APOGEE THERAPEUTICS INC | COM | $204.7M | 2.1%Prev: 1.3% | 2,712,097 SH | Increased |
| AQUESTIVE THERAPEUTICS INC | COM | $40.4M | 0.4%Prev: 0.4% | 6,250,000 SH | Increased |
| ARGENX SE | SPONSORED ADR | $566.4M | 5.7%Prev: 6.1% | 673,497 SH | Increased |
| ARROWHEAD PHARMACEUTICALS IN | COM | $38.8M | 0.4% | 584,716 SH | New |
| ATAI BECKLEY NV | SHS | $8.2M | 0.1% | 2,000,000 SH | New |
| AXSOME THERAPEUTICS INC | COM | $162.2M | 1.6%Prev: 1.7% | 888,001 SH | Increased-230,882 SH |
| BEAM THERAPEUTICS INC | COM | $15.8M | 0.2% | 570,394 SH | New |
| BELITE BIO INC | SPONSORED ADS | $114.4M | 1.1%Prev: 0.3% | 715,332 SH | Increased+402,832 SH |
| BETA BIONICS INC | COM | $76.2M | 0.8%Prev: 0.8% | 2,500,000 SH | Increased-799,191 SH |
| CAPRICOR THERAPEUTICS INC | COM NEW | $7.2M | 0.1% | 250,000 SH | New |
| CASTLE BIOSCIENCES INC | COM | $82.3M | 0.8% | 2,115,237 SH | New |
| CELCUITY INC | COM | $54.9M | 0.5% | 550,160 SH | New |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $44.8M | 0.4%Prev: 0.7% | 1,790,837 SH | Decreased-500,910 SH |
| CG ONCOLOGY INC | COM | $83.5M | 0.8%Prev: 0.8% | 2,012,127 SH | Increased+310,911 SH |
| COGENT BIOSCIENCES INC | COM | $269.7M | 2.7%Prev: 0.6% | 7,592,241 SH | Increased+4,124,755 SH |
| COMPASS PATHWAYS PLC | SPONSORED ADS | $60.4M | 0.6%Prev: 0.6% | 8,757,390 SH | Increased+50,000 SH |
| COMPASS THERAPEUTICS INC | COM | $13.4M | 0.1%Prev: 0.1% | 2,500,000 SH | Increased |
| CORVUS PHARMACEUTICALS INC | COM | $3.4M | 0.0%Prev: 0.2% | 447,607 SH | Decreased-2,231,872 SH |
| CRESCENT BIOPHARMA INC. | COM | $4.4M | 0.0% | 372,856 SH | New |
| CRINETICS PHARMACEUTICALS IN | COM | $62.9M | 0.6%Prev: 0.4% | 1,351,326 SH | Increased+478,939 SH |
| CULLINAN THERAPEUTICS INC | COM | $17.7M | 0.2%Prev: 0.1% | 1,705,960 SH | Increased |
| CYTOKINETICS INC | COM NEW | $172.9M | 1.7%Prev: 1.8% | 2,721,158 SH | Increased |
| DISC MEDICINE INC | COM | $2.4M | 0.0% | 30,000 SH | New |
| ERASCA INC | COM | $546K | 0.0% | 146,651 SH | New |
| ESTABLISHMENT LABS HLDGS INC | COM | $188.7M | 1.9%Prev: 1.3% | 2,588,831 SH | Increased |
| EVOMMUNE INC | COM SHS | $22.0M | 0.2% | 1,283,671 SH | New |
| EXAGEN INC | COM | $4.8M | 0.0%Prev: 0.2% | 790,462 SH | Decreased-906,404 SH |
| FULGENT GENETICS INC | COM | $18.5M | 0.2% | 705,027 SH | New |
| GH RESEARCH PLC | ORDINARY SHARES | $75.4M | 0.8%Prev: 1.0% | 5,933,815 SH | Decreased+364,251 SH |
| GUARDANT HEALTH INC | COM | $151.3M | 1.5%Prev: 1.1% | 1,481,033 SH | Increased |
| HEARTFLOW INC | COM | $14.4M | 0.1%Prev: 0.2% | 495,000 SH | Decreased |
| HINGE HEALTH INC | CL A | $16.4M | 0.2% | 353,500 SH | New |
| IMAGENEBIO INC | COM | $2.3M | 0.0%Prev: 0.0% | 334,445 SH | Decreased |
| IMMATICS N.V | SHS | $120.1M | 1.2%Prev: 0.9% | 11,433,354 SH | Increased+2,617,737 SH |
| IMMUNOCORE HLDGS PLC | ADS | $169.0M | 1.7%Prev: 2.2% | 4,869,798 SH | Decreased |
| IMMUNOVANT INC | COM | $80.8M | 0.8% | 3,177,850 SH | New |
| INSMED INC | COM PAR $.01 | $842.9M | 8.4%Prev: 5.5% | 4,842,879 SH | Increased+1,758,321 SH |
| INSULET CORP | COM | $92.3M | 0.9% | 324,600 SH | New |
| INTUITIVE SURGICAL INC | COM NEW | $57.3M | 0.6%Prev: 1.1% | 101,228 SH | Decreased-101,228 SH |
| INVENTIVA SA | ADS | $6.0M | 0.1% | 1,298,701 SH | New |
| IQVIA HLDGS INC | COM | $10.4M | 0.1% | 46,000 SH | New |
| IRHYTHM TECHNOLOGIES INC | COM | $209.7M | 2.1% | 1,181,990 SH | New |
| JADE BIOSCIENCES INC | COM NEW | $22.4M | 0.2%Prev: 0.2% | 1,449,273 SH | Increased |
| KALARIS THERAPEUTICS INC | COM | $11.0M | 0.1% | 1,300,000 SH | New |
| KODIAK SCIENCES INC | COM | $41.6M | 0.4% | 1,487,933 SH | New |
| KYMERA THERAPEUTICS INC | COM | $18.7M | 0.2% | 240,000 SH | New |
| LARIMAR THERAPEUTICS INC | COM | $11.9M | 0.1%Prev: 0.1% | 3,125,000 SH | Increased |
| LUMEXA IMAGING HOLDINGS INC | COM | $12.0M | 0.1% | 650,000 SH | New |
| MADRIGAL PHARMACEUTICALS INC | COM | $1.16B | 11.6%Prev: 11.3% | 1,993,687 SH | Increased |
| MASIMO CORP | COM | $88.9M | 0.9%Prev: 1.2% | 683,294 SH | Decreased |
| MEDLINE INC | COM CL A | $2.9M | 0.0% | 70,000 SH | New |
| MILESTONE PHARMACEUTICALS IN | COM | $5.1M | 0.1%Prev: 0.1% | 2,506,102 SH | Increased |
| MIND MEDICINE MINDMED INC | COM NEW | $4.0M | 0.0% | 300,000 SH | New |
| NATERA INC | COM | $343.6M | 3.4%Prev: 4.0% | 1,500,000 SH | Increased-500,000 SH |
| NEUROCRINE BIOSCIENCES INC | COM | $150.6M | 1.5%Prev: 1.8% | 1,062,072 SH | Increased |
| NEUROGENE INC | COM | $28.1M | 0.3%Prev: 0.3% | 1,362,456 SH | Increased |
| OMADA HEALTH INC | COM | $3.2M | 0.0%Prev: 0.1% | 200,000 SH | Decreased |
| ORCHESTRA BIOMED HLDGS INC | COM | $34.5M | 0.3%Prev: 0.3% | 8,306,063 SH | Increased |
| ORUKA THERAPEUTICS INC | COM | $62.4M | 0.6%Prev: 0.5% | 2,058,148 SH | Increased+112,499 SH |
| PENUMBRA INC | COM | $269.4M | 2.7%Prev: 2.7% | 866,499 SH | Increased |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | $9.7M | 0.1%Prev: 0.1% | 742,500 SH | Increased |
| PROTAGONIST THERAPEUTICS INC | COM | $441.9M | 4.4%Prev: 4.7% | 5,059,053 SH | Increased-697,224 SH |
| PTC THERAPEUTICS INC | COM | $588.4M | 5.9%Prev: 5.9% | 7,746,415 SH | Increased |
| RADNET INC | COM | $281.0M | 2.8%Prev: 2.6% | 3,938,500 SH | Increased+1,122,956 SH |
| RAPT THERAPEUTICS INC | COM NEW | $55.5M | 0.6%Prev: 0.5% | 1,637,165 SH | Increased+166,666 SH |
| REPLIGEN CORP | COM | $174.3M | 1.7% | 1,064,000 SH | New |
| REPLIMUNE GROUP INC | COM | $69.4M | 0.7%Prev: 0.3% | 7,140,352 SH | Increased+744,620 SH |
| ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | $9K | 0.0%Prev: 0.0% | 350,000 SH | Decreased |
| ROCKET PHARMACEUTICALS INC | COM | $62.1M | 0.6%Prev: 0.7% | 17,687,772 SH | Increased |
| SAVARA INC | COM | $35.9M | 0.4% | 5,952,380 SH | New |
| SPYRE THERAPEUTICS INC | COM NEW | $136.7M | 1.4%Prev: 0.7% | 4,171,996 SH | Increased+550,000 SH |
| STOKE THERAPEUTICS INC | COM | $176.1M | 1.8%Prev: 1.5% | 5,546,856 SH | Increased+423,331 SH |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $7.0M | 0.1% | 100,000 SH | New |
| STRYKER CORPORATION | COM | $86.1M | 0.9%Prev: 2.2% | 245,000 SH | Decreased-245,000 SH |
| TANGO THERAPEUTICS INC | COM | $13.2M | 0.1% | 1,491,228 SH | New |
| TARSUS PHARMACEUTICALS INC | COM | $273.1M | 2.7%Prev: 2.3% | 3,335,320 SH | Increased+157,884 SH |
| TAYSHA GENE THERAPIES INC | COM SHS | $90.2M | 0.9%Prev: 1.0% | 16,398,297 SH | Increased-7,955,994 SH |
| TEMPUS AI INC | CL A | $11.8M | 0.1%Prev: 0.2% | 200,000 SH | Decreased |
| TENAX THERAPEUTICS INC | COM NEW | $4.6M | 0.0%Prev: 0.0% | 378,346 SH | Increased |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $69.0M | 0.7%Prev: 1.2% | 3,000,139 SH | Decreased-258,127 SH |
| UNIQURE NV | SHS | $88.8M | 0.9%Prev: 3.2% | 3,711,462 SH | Decreased-713,506 SH |
| UROGEN PHARMA LTD | COM | $106.4M | 1.1%Prev: 1.1% | 4,543,895 SH | Increased |
| VERASTEM INC | COM NEW | $50.8M | 0.5%Prev: 0.6% | 6,576,306 SH | Increased+1,150,000 SH |
| WAVE LIFE SCIENCES LTD | SHS | $22.9M | 0.2%Prev: 0.1% | 1,350,000 SH | Increased+450,000 SH |
| XENCOR INC | COM | $103.8M | 1.0%Prev: 0.9% | 6,777,461 SH | Increased+556,407 SH |
| ZAI LAB LTD | ADR | $122.8M | 1.2%Prev: 1.0% | 6,959,032 SH | Increased+4,667,660 SH |