| 4D MOLECULAR THERAPEUTICS IN | SH | $42.4M | 0.4%Prev: 0.5% | 5,653,211 SH | Increased+1,090,000 SH |
| ACRIVON THERAPEUTICS INC | SH | $20.1M | 0.2%Prev: 0.2% | 8,340,508 SH | Increased |
| ACUMEN PHARMACEUTICALS INC | SH | $31.5M | 0.3%Prev: 0.3% | 14,932,063 SH | Increased |
| ADICET BIO INC | SH | $8.0M | 0.1%Prev: 0.1% | 948,249 SH | Increased-6,592,751 SH |
| ARCELLX INC | SH | $82.6M | 0.8%Prev: 3.1% | 1,267,156 SH | Decreased-1,769,371 SH |
| ARS PHARMACEUTICALS INC | SH | $126.5M | 1.3%Prev: 1.3% | 10,860,977 SH | Increased |
| ARTIVA BIOTHERAPEUTICS INC | SH | $42.3M | 0.4%Prev: 0.3% | 9,853,302 SH | Increased |
| ASCENDIS PHARMA A/S - ADR | SH | $2.19B | 22.5%Prev: 25.2% | 10,281,496 SH | Increased |
| ASSEMBLY BIOSCIENCES INC | SH | $34.7M | 0.4%Prev: 0.3% | 1,020,410 SH | Increased |
| AVALO THERAPEUTICS INC | SH | $12.0M | 0.1%Prev: 0.1% | 662,968 SH | Increased |
| AVIDITY BIOSCIENCES INC | SH | $623.3M | 6.4%Prev: 4.6% | 8,641,031 SH | Increased |
| BELITE BIO INC - ADR | SH | $69.2M | 0.7%Prev: 0.8% | 432,484 SH | Increased-442,516 SH |
| BENITEC BIOPHARMA INC | SH | $24.9M | 0.3% | 1,850,000 SH | New |
| BICARA THERAPEUTICS INC | SH | $117.1M | 1.2%Prev: 1.4% | 6,955,993 SH | Increased |
| BIOCRYST PHARMACEUTICALS INC | SH | $123.5M | 1.3% | 15,827,186 SH | New |
| C4 THERAPEUTICS INC | SH | $15.3M | 0.2% | 8,000,000 SH | New |
| CAPRICOR THERAPEUTICS INC | SH | $43.5M | 0.4% | 1,507,844 SH | New |
| CIDARA THERAPEUTICS INC | SH | $743.4M | 7.6%Prev: 4.0% | 3,365,523 SH | Increased |
| CLIMB BIO INC | SH | $77.7M | 0.8%Prev: 0.8% | 11,293,828 SH | Increased-20,125,439 SH |
| CONTINEUM THERAPEUTICS INC-A | SH | $24.9M | 0.3%Prev: 0.3% | 2,179,711 SH | Decreased+57,711 SH |
| DESIGN THERAPEUTICS INC | SH | $13.7M | 0.1%Prev: 0.0% | 1,461,381 SH | Increased+985,682 SH |
| DIANTHUS THERAPEUTICS INC | SH | $66.4M | 0.7%Prev: 1.4% | 1,611,733 SH | Decreased-1,255,000 SH |
| DISC MEDICINE INC | SH | $156.9M | 1.6%Prev: 1.3% | 1,976,132 SH | Increased+399,026 SH |
| EDGEWISE THERAPEUTICS INC | SH | $258.8M | 2.7%Prev: 2.1% | 10,428,437 SH | Increased |
| EVOMMUNE INC | SH | $59.2M | 0.6% | 3,458,770 SH | New |
| FULCRUM THERAPEUTICS INC | SH | $68.5M | 0.7%Prev: 1.2% | 6,053,960 SH | Decreased-4,175,139 SH |
| GENEDX HOLDINGS CORP | SH | $7.5M | 0.1%Prev: 0.1% | 58,044 SH | Increased |
| GERON CORP | SH | $84.2M | 0.9%Prev: 1.0% | 63,771,366 SH | Increased+3,392,000 SH |
| GH RESEARCH PLC | SH | $97.5M | 1.0%Prev: 1.4% | 7,676,697 SH | Decreased |
| GRAIL INC | SH | $36.7M | 0.4% | 428,266 SH | New |
| HEALTH CATALYST INC | SH | $1.9M | 0.0% | 793,749 SH | New |
| HINGE HEALTH INC-A | SH | $3.7M | 0.0% | 80,113 SH | New |
| INSPIRE MEDICAL SYSTEMS INC | SH | $13.1M | 0.1%Prev: 0.1% | 141,964 SH | Increased+27,063 SH |
| INVIVYD INC | SH | $42.3M | 0.4%Prev: 0.2% | 17,119,096 SH | Increased |
| JADE BIOSCIENCES INC | SH | $56.6M | 0.6%Prev: 0.1% | 3,671,083 SH | Increased+2,608,757 SH |
| JANUX THERAPEUTICS INC | SH | $154.4M | 1.6%Prev: 3.4% | 11,189,693 SH | Decreased |
| LB PHARMACEUTICALS INC | SH | $49.2M | 0.5%Prev: 0.3% | 2,208,604 SH | Increased+431,646 SH |
| LENZ THERAPEUTICS INC | SH | $66.9M | 0.7%Prev: 2.4% | 4,178,823 SH | Decreased |
| LEXEO THERAPEUTICS INC | SH | $49.6M | 0.5% | 5,000,000 SH | New |
| MEDLINE INC-CL A | SH | $14.1M | 0.1% | 335,000 SH | New |
| MINERALYS THERAPEUTICS INC | SH | $265.8M | 2.7%Prev: 3.4% | 7,323,750 SH | Decreased |
| MONOPAR THERAPEUTICS INC | SH | $43.6M | 0.4%Prev: 0.5% | 667,207 SH | Increased+156,000 SH |
| NEWAMSTERDAM PHARMA CO NV | SH | $335.0M | 3.4%Prev: 3.6% | 9,550,191 SH | Increased-588,747 SH |
| NEWAMSTERDAM PHARMA CO NV-27 | SH | $7.7M | 0.1%Prev: 0.1% | 333,333 SH | Increased |
| NKARTA INC | SH | $20.0M | 0.2%Prev: 0.3% | 10,805,129 SH | Decreased |
| NUVALENT INC-A | SH | $189.1M | 1.9%Prev: 1.3% | 1,880,057 SH | Increased+633,601 SH |
| OLEMA PHARMACEUTICALS INC | SH | $65.0M | 0.7% | 2,600,000 SH | New |
| ORTHOPEDIATRICS CORP | SH | $2.0M | 0.0% | 109,959 SH | New |
| OVID THERAPEUTICS INC | SH | $17.5M | 0.2% | 10,714,000 SH | New |
| PALATIN TECHNOLOGIES INC | SH | $1.1M | 0.0% | 70,000 SH | New |
| PALISADE BIO INC | SH | $16.7M | 0.2% | 7,124,116 SH | New |
| PEPGEN INC | SH | $130.6M | 1.3%Prev: 1.1% | 20,064,545 SH | Increased |
| PERCEPTIVE CAPITAL SOLUTIONS | SH | $9.8M | 0.1%Prev: 0.1% | 750,000 SH | Increased |
| PRAXIS PRECISION MEDICINES I | SH | $110.2M | 1.1% | 373,787 SH | New |
| PROGYNY INC | SH | $2.5M | 0.0%Prev: 0.0% | 96,628 SH | Increased |
| QIAGEN N.V. | SH | $2.1M | 0.0% | 43,976 SH | New |
| RANI THERAPEUTICS HOLDINGS-A | SH | $11.5M | 0.1% | 8,500,000 SH | New |
| REZOLUTE INC | SH | $21.7M | 0.2% | 9,180,000 SH | New |
| RHYTHM PHARMACEUTICALS INC | SH | $713.6M | 7.3%Prev: 7.1% | 6,666,837 SH | Increased+985,478 SH |
| SAB BIOTHERAPEUTICS INC | SH | $16.5M | 0.2%Prev: 0.1% | 4,401,500 SH | Increased |
| SEPTERNA INC | SH | $195.0M | 2.0%Prev: 1.6% | 6,995,858 SH | Increased |
| SIONNA THERAPEUTICS INC | SH | $407.5M | 4.2%Prev: 3.8% | 9,905,045 SH | Increased-540,277 SH |
| SOLID BIOSCIENCES INC | SH | $32.8M | 0.3%Prev: 0.4% | 5,811,423 SH | Decreased |
| SPYRE THERAPEUTICS INC | SH | $53.1M | 0.5% | 1,621,620 SH | New |
| TAYSHA GENE THERAPIES INC | SH | $129.6M | 1.3%Prev: 0.9% | 23,555,648 SH | Increased |
| TYRA BIOSCIENCES INC | SH | $320.7M | 3.3%Prev: 2.1% | 12,198,625 SH | Increased |
| VAXCYTE INC | SH | $494.8M | 5.1%Prev: 5.3% | 10,724,599 SH | Increased-1,241,392 SH |
| VOR BIOPHARMA INC | SH | $70.7M | 0.7%Prev: 1.2% | 5,404,998 SH | Decreased+3,422,697 SH |
| WAVE LIFE SCIENCES LTD | SH | $309.5M | 3.2%Prev: 1.6% | 18,203,009 SH | Increased+1,000 SH |
| WAYSTAR HOLDING CORP | SH | $4.7M | 0.0% | 144,400 SH | New |
| WEREWOLF THERAPEUTICS INC | SH | $4.2M | 0.0%Prev: 0.2% | 6,681,307 SH | Decreased |