PERCEPTIVE ADVISORS LLC

CIK 0001224962 • 8 13F filings • May 15, 2025 – Aug 14, 2026

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Filer information

Filed by: PERCEPTIVE ADVISORS LLC, Managing Member
Address: 51 ASTOR PLACE, 10TH FLOOR, NEW YORK, NY, 10003
Phone: 646-205-5342
AUM: $5.61B

AUM over time

$6.66B latest

Sector allocation over time

Past 5 quarters

Q4 2025

Q3 2025

Q2 2026

Q2 2025

Q1 2026

HealthcareOther

Holdings by filing

Portfolio value: $5.61B116 positionsView on SEC.gov

			% of Portfolio
ABIVAX SA	SPONSORED ADS	$61.8M	1.1%Prev: 1.0%	458,343 SH	Increased+69,735 SH
ADAGIO MED HLDGS INC	COM	$10.3M	0.2%Prev: 0.6%	9,876,576 SH	Decreased
ADMA BIOLOGICS INC	COM	$16.1M	0.3%Prev: 0.5%	883,468 SH	Decreased-270,000 SH
ALDEYRA THERAPEUTICS INC	COM	$21.7M	0.4%Prev: 0.8%	4,185,632 SH	Decreased-1,036,679 SH
ALTO NEUROSCIENCE INC	COM SHS	$31.8M	0.6%Prev: 0.0%	1,784,393 SH	Increased+1,629,027 SH
AMICUS THERAPEUTICS INC	COM	$90.7M	1.6%Prev: 1.4%	6,370,851 SH	Increased
AMYLYX PHARMACEUTICALS INC	COM	$100.1M	1.8%Prev: 3.5%	8,284,882 SH	Decreased-667,483 SH
ANTERIS TECHNOLOGIES GLOBAL	COM	$8.4M	0.1%Prev: 0.2%	1,675,476 SH	Increased-29,654 SH
APOGEE THERAPEUTICS INC	COM	$175.9M	3.1%Prev: 1.6%	2,330,651 SH	Increased+978,662 SH
AQUESTIVE THERAPEUTICS INC	COM	$4.8M	0.1%Prev: 0.6%	747,193 SH	Decreased-3,012,906 SH
ARCELLX INC	COMMON STOCK	$95.6M	1.7%Prev: 5.9%	1,466,071 SH	Decreased-1,002,282 SH
ARTIVION INC	COM	$78.6M	1.4%Prev: 2.5%	1,722,290 SH	Decreased-297,710 SH
ASCENDIS PHARMA A/S	SPONSORED ADR	$230.6M	4.1%Prev: 6.2%	1,081,421 SH	Increased-7,080 SH
ASTRIA THERAPEUTICS INC	COM	$84.9M	1.5%Prev: 1.4%	6,485,420 SH	Increased
ATHIRA PHARMA INC	COM	$14.1M	0.3%Prev: 0.1%	1,859,322 SH	Increased+1,319,026 SH
AVALO THERAPEUTICS INC	COM NEW	$2.5M	0.0%Prev: 0.1%	139,667 SH	Increased
AXOGEN INC	COM	$25.7M	0.5%	784,140 SH	New
AXSOME THERAPEUTICS INC	COM	$27.2M	0.5%Prev: 0.5%	148,900 SH	Increased
BELITE BIO INC	SPONSORED ADS	$66.3M	1.2%Prev: 0.1%	414,239 SH	Increased+364,451 SH
BETA BIONICS INC	COM	$18.4M	0.3%Prev: 0.2%	602,944 SH	Increased+325,000 SH
BILLIONTOONE INC	CL A	$6.0M	0.1%	72,812 SH	New
BIOCRYST PHARMACEUTICALS INC	COM	$24.7M	0.4%	3,162,529 SH	New
BIODESIX	COM	$739K	0.0%Prev: 0.0%	108,694 SH	Decreased
BIOGEN INC	COM	$21.8M	0.4%	124,000 SH	New
BIOHAVEN LTD	COM	$5.6M	0.1%	500,000 SH	New
BOSTON SCIENTIFIC CORP	COM	$93.3M	1.7%Prev: 0.9%	979,000 SH	Increased+669,000 SH
BRIGHT MINDS BIOSCIENCES INC	COM NEW	$35.1M	0.6%Prev: 0.8%	449,290 SH	Increased
CAPRICOR THERAPEUTICS INC	COM NEW	$7.0M	0.1%	242,100 SH	New
CARIS LIFE SCIENCES INC	COM	$30.7M	0.5%Prev: 1.0%	1,136,206 SH	Decreased+38,043 SH
CELCUITY INC	COM	$315.2M	5.6%Prev: 4.2%	3,160,200 SH	Increased+203,881 SH
CELCUITY INC	NOTE 2.750% 8/0	$14.1M	0.3%	6,500,000 PRN	New
CENTESSA PHARMACEUTICALS PLC	SPONSORED ADS	$73.0M	1.3%Prev: 2.2%	2,917,634 SH	Decreased-183,268 SH
CIDARA THERAPEUTICS INC	COM NEW	$36.5M	0.7%	165,131 SH	New
COGENT BIOSCIENCES INC	COM	$4.3M	0.1%	121,082 SH	New
CONNECT BIOPHARMA HLDGS LTD	SHS	$2.2M	0.0%	792,696 SH	New
CONTINEUM THERAPEUTICS INC	CL A	$16.7M	0.3%Prev: 0.2%	1,464,592 SH	Increased+750,000 SH
CORVUS PHARMACEUTICALS INC	COM	$5.3M	0.1%Prev: 0.3%	692,441 SH	Decreased-746,154 SH
CRESCENT BIOPHARMA INC.	COM	$5.4M	0.1%Prev: 0.2%	453,686 SH	Decreased
CUMBERLAND PHARMACEUTICALS I	COM	$1.4M	0.0%	341,087 SH	New
CVS HEALTH CORP	COM	$17.5M	0.3%	220,000 SH	New
CYTOMX THERAPEUTICS INC	COM	$41.2M	0.7%Prev: 0.9%	9,680,185 SH	Increased
DANAHER CORPORATION	COM	$45.8M	0.8%	200,000 SH	New
DEXCOM INC	COM	$15.0M	0.3%	225,758 SH	New
DISC MEDICINE INC	COM	$35.8M	0.6%	450,743 SH	New
DYNE THERAPEUTICS INC	COM	$68.0M	1.2%Prev: 0.2%	3,478,944 SH	Increased+2,938,500 SH
EDGEWISE THERAPEUTICS	COM	$110.6M	2.0%	4,457,974 SH	New
ENGENE HOLDINGS INC	COM	$53.0M	0.9%Prev: 0.4%	5,869,076 SH	Increased+3,771,840 SH
ENSYSCE BIOSCIENCES INC	COM NEW	$80K	0.0%Prev: 0.0%	86,666 SH	Decreased
ENVVENO MEDICAL CORPORATION	COM	$564K	0.0%Prev: 0.0%	1,759,035 SH	Decreased
EXACT SCIENCES CORP	COM	$121.9M	2.2%Prev: 0.7%	1,200,487 SH	Increased+735,000 SH
GLAUKOS CORP	COM	$15.8M	0.3%	140,000 SH	New
GOSSAMER BIO INC	COM	$9.7M	0.2%Prev: 0.3%	3,139,669 SH	Decreased-673,128 SH
GRAIL INC	COM	$20.3M	0.4%	237,342 SH	New
GUARDANT HEALTH INC	COM	$16.3M	0.3%	160,000 SH	New
IMMATICS N.V	SHS	$109.0M	1.9%Prev: 2.3%	10,383,456 SH	Increased+1,000,000 SH
IMMIX BIOPHARMA INC	COM	$1.8M	0.0%	338,941 SH	New
IMMUNOVANT INC	COM	$50.7M	0.9%Prev: 0.7%	1,994,890 SH	Increased+407,000 SH
INHIBIKASE THERAPEUTICS INC	COM NEW	$11.1M	0.2%Prev: 0.3%	5,421,568 SH	Increased
INHIBRX BIOSCIENCES INC	COM	$114.8M	2.0%Prev: 1.3%	1,452,707 SH	Increased+125,000 SH
INTUITIVE SURGICAL INC	COM NEW	$49.8M	0.9%Prev: 0.7%	87,919 SH	Increased+35,800 SH
INVIVYD INC	COM	$53.8M	1.0%	21,785,166 SH	New
IOVANCE BIOTHERAPEUTICS INC	COM	$417K	0.0%	152,714 SH	New
IRHYTHM TECHNOLOGIES INC	COM	$19.2M	0.3%Prev: 0.6%	108,000 SH	Decreased-15,000 SH
JAZZ PHARMACEUTICALS PLC	SHS USD	$28.9M	0.5%	170,000 SH	New
KESTRA MED TECHNOLOGIES LTD	SHS	$7.6M	0.1%	285,000 SH	New
KODIAK SCIENCES INC	COM	$23.7M	0.4%Prev: 0.3%	848,900 SH	Increased+214,323 SH
KRYSTAL BIOTECH INC	COM	$4.3M	0.1%Prev: 0.2%	17,500 SH	Decreased-17,500 SH
KYMERA THERAPEUTICS INC	COM	$5.4M	0.1%Prev: 0.3%	69,935 SH	Decreased-99,861 SH
LENZ THERAPEUTICS INC	COM	$800K	0.0%	50,000 SH	New
LEXEO THERAPEUTICS INC	COM	$1.4M	0.0%Prev: 0.0%	139,835 SH	Increased
MAPLIGHT THERAPEUTICS INC	COM	$9.7M	0.2%	550,000 SH	New
MEDLINE INC	COM CL A	$1.2M	0.0%	28,000 SH	New
MEIRAGTX HLDGS PLC	COM	$82.1M	1.5%Prev: 3.0%	10,326,103 SH	Decreased-2,300,000 SH
MIRUM PHARMACEUTICALS INC	COM	$20.5M	0.4%	259,545 SH	New
NAUTILUS BIOTECHNOLOGY INC	COM	$24.6M	0.4%Prev: 0.3%	12,594,211 SH	Increased
NEUROCRINE BIOSCIENCES INC	COM	$47.0M	0.8%Prev: 1.8%	331,050 SH	Decreased-119,000 SH
NURIX THERAPEUTICS INC	COM	$67.5M	1.2%Prev: 0.4%	3,555,877 SH	Increased+2,139,728 SH
NUVALENT INC	COM	$167.5M	3.0%Prev: 3.9%	1,665,105 SH	Increased+102,769 SH
OCULIS HOLDING AG	ORDINARY SHARES	$9.9M	0.2%	493,827 SH	New
OLEMA PHARMACEUTICALS INC	COM	$4.1M	0.1%	165,713 SH	New
OMADA HEALTH INC	COM	$37.8M	0.7%Prev: 1.5%	2,396,330 SH	Decreased
OPUS GENETICS INC	COM	$8.7M	0.2%Prev: 0.2%	4,325,000 SH	Increased
ORCHESTRA BIOMED HLDGS INC	COM	$21.3M	0.4%Prev: 0.4%	5,127,256 SH	Increased-165,300 SH
ORUKA THERAPEUTICS INC	COM	$44.8M	0.8%Prev: 0.7%	1,476,501 SH	Increased+208,480 SH
OUTSET MED INC	COM NEW	$3.1M	0.1%Prev: 0.3%	833,333 SH	Decreased
PALATIN TECHNOLOGIES INC	COM NEW	$1.1M	0.0%	70,000 SH	New
PALISADE BIO INC	COM	$28.3M	0.5%	12,050,000 SH	New
PALVELLA THERAPEUTICS INC NE	COM	$27.9M	0.5%Prev: 0.7%	266,287 SH	Increased-128,806 SH
PENUMBRA INC	COM	$34.4M	0.6%Prev: 1.6%	110,529 SH	Decreased-110,018 SH
PEPGEN INC	COM	$5.4M	0.1%Prev: 0.1%	829,870 SH	Increased
PRAXIS PRECISION MEDICINES I	COM NEW	$588.3M	10.5%Prev: 2.4%	1,995,986 SH	Increased+431,432 SH
PROTAGONIST THERAPEUTICS INC	COM	$117.9M	2.1%Prev: 2.0%	1,350,425 SH	Increased+320,291 SH
RAPPORT THERAPEUTICS INC	COM	$20.4M	0.4%Prev: 0.3%	673,923 SH	Increased+270,000 SH
RAPT THERAPEUTICS INC	COM NEW	$28.0M	0.5%Prev: 0.1%	825,890 SH	Increased+642,000 SH
RELAY THERAPEUTICS INC	COM	$16.1M	0.3%	1,903,245 SH	New
REPLIGEN CORP	COM	$51.7M	0.9%Prev: 1.0%	315,541 SH	Increased+45,113 SH
REVOLUTION MEDICINES INC	*W EXP 12/17/202	$235K	0.0%Prev: 0.0%	250,000 SH	Increased
RHYTHM PHARMACEUTICALS INC	COM	$272.6M	4.9%Prev: 8.3%	2,546,391 SH	Decreased-416,558,578 SH
ROIVANT SCIENCES LTD	SHS	$173.3M	3.1%Prev: 3.2%	7,985,461 SH	Increased+617,000 SH
SAB BIOTHERAPEUTICS INC	COM NEW	$3.0M	0.1%	803,210 SH	New
SAVARA INC	COM	$14.5M	0.3%	2,400,000 SH	New
SCHRODINGER INC	COM	$3.6M	0.1%	202,400 SH	New
SEPTERNA INC	COM	$12.1M	0.2%Prev: 0.3%	433,160 SH	Increased-108,290 SH
SIONNA THERAPEUTICS INC	COM	$48.5M	0.9%Prev: 1.0%	1,179,098 SH	Increased
SOLID BIOSCIENCES INC	COM NEW	$66.7M	1.2%Prev: 2.1%	11,833,539 SH	Decreased
SPDR SERIES TRUST	STATE STREET SPD	$134.1M	2.4%	1,100,000 SH	New
SPYRE THERAPEUTICS INC	COM NEW	$100.5M	1.8%Prev: 0.6%	3,069,225 SH	Increased+1,839,780 SH
SURROZEN INC	*W EXP 08/01/203	$3K	0.0%Prev: 0.0%	166,666 SH	Increased
TANGO THERAPEUTICS INC	COM	$4.5M	0.1%	513,035 SH	New
TECTONIC THERAPEUTIC INC	COM	$5.2M	0.1%	250,000 SH	New
TENAX THERAPEUTICS INC	COM NEW	$5.4M	0.1%	439,142 SH	New
TRAVERE THERAPEUTICS INC	COM	$163.5M	2.9%Prev: 2.6%	4,278,180 SH	Increased+483,565 SH
VIRIDIAN THERAPEUTICS INC	COM	$94.7M	1.7%Prev: 0.9%	3,042,703 SH	Increased+1,580,303 SH
X4 PHARMACEUTICALS INC	COM NEW	$25.3M	0.5%	6,314,452 SH	New
XENON PHARMACEUTICALS INC	COM	$9.0M	0.2%Prev: 0.2%	200,791 SH	Increased
ZYMEWORKS INC	COM	$85.9M	1.5%Prev: 1.0%	3,261,850 SH	Increased+1,171,187 SH

Sold (vs prior filing)

AKERO THERAPEUTICS INC — $53.9M
APYX MEDICAL CORPORATION — $321K
ARS PHARMACEUTICALS INC — $2.0M
CELCUITY INC — $8.7M
EDGEWISE THERAPEUTICS INC — $61.6M
HEARTFLOW INC — $5.0M
INSMED INC — $101.1M
JANUX THERAPEUTICS INC — $7.2M
LYRA THERAPEUTICS INC — $1.5M
MERUS N V — $127.4M
PYXIS ONCOLOGY INC — $2.6M
SCPHARMACEUTICALS INC — $3.3M
TEMPUS AI INC — $6.9M
TRINITY BIOTECH PLC — $1.9M
UNIQURE NV — $1.2M
VERONA PHARMA PLC — $55.9M
VIKING THERAPEUTICS INC — $2.8M

All filings

Open a filing on Jive Data

Filing Date	Quarter	Form	Accession	Portfolio	Filing
Feb 17, 2026	Q4 2025	13F-HR	0001012975-26-000155	$5.61B	View
Nov 14, 2025	Q3 2025	13F-HR	0001012975-25-000762	$3.46B	View
Aug 14, 2026	Q2 2026