ORBIMED ADVISORS LLC

CIK 0001055951 • 6 13F filings • May 15, 2025 – Aug 14, 2026

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Filer information

Filed by: ORBIMED ADVISORS LLC, Member
Address: 601 Lexington Avenue, 54th Floor, New York, NY, 10022
Phone: 212-739-6400
AUM: $4.90B

AUM over time

$5.40B latest

Sector allocation over time

Past 5 quarters

Q4 2025

Q3 2025

Q2 2026

Q2 2025

Q1 2026

HealthcareOther

Holdings by filing

Portfolio value: $4.90B1 positionsView on SEC.gov

			% of Portfolio
ABIVAX SA	SPONSORED ADS	$49.6M	1.0%Prev: 0.8%	367,900 SH	Increased-12,100 SH
ADC THERAPEUTICS SA	SHS	$20.6M	0.4%Prev: 0.6%	5,822,854 SH	Decreased-84,497 SH
ADICET BIO INC	COM NEW	$8.7M	0.2%	1,027,944 SH	New
ALNYLAM PHARMACEUTICALS INC	COM	$114.8M	2.3%Prev: 3.2%	288,800 SH	Decreased-12,800 SH
ALTO NEUROSCIENCE INC	COM SHS	$2.2M	0.0%Prev: 0.0%	125,000 SH	Increased-125,000 SH
ALUMIS INC	COM	$10.8M	0.2%Prev: 0.2%	1,102,730 SH	Increased-823,693 SH
AMICUS THERAPEUTICS INC	COM	$10.4M	0.2%Prev: 0.3%	729,900 SH	Decreased-915,500 SH
APELLIS PHARMACEUTICALS INC	COM	$61.0M	1.2%Prev: 1.4%	2,429,868 SH	Increased-143,500 SH
ARGENX SE	SPONSORED ADR	$122.8M	2.5%Prev: 3.0%	146,000 SH	Decreased-26,300 SH
ARRIVENT BIOPHARMA INC	COM	$60.9M	1.2%Prev: 1.3%	3,027,328 SH	Increased
ARS PHARMACEUTICALS INC	COM	$96.6M	2.0%Prev: 2.0%	8,288,510 SH	Increased
ASCENDIS PHARMA A/S	SPONSORED ADR	$36.7M	0.7%Prev: 0.9%	171,977 SH	Decreased-19,928 SH
AVALO THERAPEUTICS INC	COM NEW	$21.6M	0.4%Prev: 0.4%	1,187,300 SH	Increased-162,000 SH
AVIDITY BIOSCIENCES INC	COM	$44.7M	0.9%Prev: 1.7%	619,530 SH	Decreased-1,019,356 SH
AXSOME THERAPEUTICS INC	COM	$46.2M	0.9%Prev: 1.5%	253,121 SH	Decreased-278,679 SH
BICARA THERAPEUTICS INC	COM	$3.5M	0.1%	209,100 SH	New
BIOAGE LABS INC	COM	$10.5M	0.2%Prev: 0.1%	790,901 SH	Increased
BIOCRYST PHARMACEUTICALS INC	COM	$13.6M	0.3%Prev: 0.2%	1,741,800 SH	Increased+840,300 SH
BOSTON SCIENTIFIC CORP	COM	$230.7M	4.7%Prev: 6.0%	2,419,300 SH	Decreased-210,000 SH
BRIGHTSPRING HEALTH SVCS INC	COM	$18.3M	0.4%Prev: 0.3%	488,500 SH	Increased+74,700 SH
BRISTOL-MYERS SQUIBB CO	COM	$41.8M	0.9%	775,000 SH	New
BRUKER CORP	COM	$26.2M	0.5%	555,789 SH	New
C4 THERAPEUTICS INC	COM STK	$2.7M	0.1%Prev: 0.3%	1,404,902 SH	Decreased-3,830,244 SH
CARIS LIFE SCIENCES INC	COM	$84.1M	1.7%Prev: 2.2%	3,116,011 SH	Decreased+81,153 SH
CARLSMED INC	COM	$15.5M	0.3%Prev: 0.4%	1,252,600 SH	Decreased
CELCUITY INC	COM	$8.5M	0.2%Prev: 0.1%	85,664 SH	Increased+1,644 SH
CG ONCOLOGY INC	COM	$63.0M	1.3%Prev: 1.6%	1,516,550 SH	Decreased-210,300 SH
COGENT BIOSCIENCES INC	COM	$13.2M	0.3%	371,000 SH	New
COGENT BIOSCIENCES INC	NOTE 1.625%11/1	$1.2M	0.0%	1,000,000 PRN	New
COMPASS THERAPEUTICS INC	COM	$81.7M	1.7%Prev: 1.3%	15,219,994 SH	Increased
CORBUS PHARMACEUTICALS HLDGS	COM NEW	$13.0M	0.3%Prev: 0.3%	1,597,287 SH	Decreased+425,000 SH
CORVUS PHARMACEUTICALS INC	COM	$55.2M	1.1%Prev: 1.2%	7,165,006 SH	Increased
CRINETICS PHARMACEUTICALS IN	COM	$46.5M	0.9%Prev: 1.2%	999,000 SH	Decreased-200,000 SH
CULLINAN THERAPEUTICS INC	COM	$2.8M	0.1%Prev: 0.3%	270,006 SH	Decreased-1,653,849 SH
CYBIN INC	COM NEW	$31.4M	0.6%	3,840,500 SH	New
CYTOMX THERAPEUTICS INC	COM	$15.0M	0.3%Prev: 0.6%	3,525,650 SH	Decreased-4,935,850 SH
DANAHER CORPORATION	COM	$68.6M	1.4%Prev: 1.2%	299,800 SH	Increased+36,700 SH
DISC MEDICINE INC	COM	$84.8M	1.7%Prev: 2.2%	1,067,550 SH	Decreased-347,470 SH
DYNE THERAPEUTICS INC	COM	$43.1M	0.9%Prev: 0.7%	2,202,184 SH	Increased-112,000 SH
EDGEWISE THERAPEUTICS INC	COM	$385.1M	7.9%Prev: 5.9%	15,518,492 SH	Increased
EDWARDS LIFESCIENCES CORP	COM	$169.9M	3.5%Prev: 3.1%	1,992,900 SH	Increased+308,900 SH
ELEVANCE HEALTH INC FORMERLY	COM	$34.7M	0.7%	99,100 SH	New
ELI LILLY & CO	COM	$323.7M	6.6%Prev: 5.4%	301,200 SH	Increased
ENLIVEN THERAPEUTICS INC	COM	$122.6M	2.5%Prev: 3.8%	7,959,538 SH	Decreased
ESPERION THERAPEUTICS INC NE	COM	$22.1M	0.5%	5,965,498 SH	New
EXACT SCIENCES CORP	COM	$35.7M	0.7%Prev: 1.3%	351,716 SH	Decreased-642,900 SH
EYEPOINT INC	COM NEW	$45.1M	0.9%	2,468,314 SH	New
FORTE BIOSCIENCES INC	COM NEW	$32.6M	0.7%Prev: 0.4%	1,196,955 SH	Increased
IMAGENEBIO INC	COM	$2.6M	0.1%Prev: 0.1%	378,556 SH	Decreased
IMAGENEBIO INC	NONVOTING	$3.7M	0.1%Prev: 0.1%	530,713 SH	Decreased
INSMED INC	COM PAR $.01	$4.4M	0.1%Prev: 0.0%	25,400 SH	Increased+11,941 SH
INSPIREMD INC	COM	$5.6M	0.1%Prev: 0.1%	3,133,405 SH	Increased+1,000,000 SH
INTUITIVE SURGICAL INC	COM NEW	$149.2M	3.0%Prev: 3.0%	263,400 SH	Increased-23,800 SH
JADE BIOSCIENCES INC	COM NEW	$8.2M	0.2%Prev: 0.1%	531,163 SH	Increased
JANUX THERAPEUTICS INC	COM	$27.0M	0.6%Prev: 1.0%	1,954,426 SH	Decreased+188,326 SH
KALVISTA PHARMACEUTICALS INC	COM	$6.2M	0.1%	382,400 SH	New
KEROS THERAPEUTICS INC	COM	$16.4M	0.3%Prev: 0.4%	804,212 SH	Increased-214,522 SH
KINIKSA PHARMACEUTICALS INTL	ORD SHS CL A	$7.7M	0.2%	187,199 SH	New
KRYSTAL BIOTECH INC	COM	$29.5M	0.6%Prev: 0.4%	119,800 SH	Increased+17,055 SH
LEXEO THERAPEUTICS INC	COM	$21.1M	0.4%	2,125,000 SH	New
MAPLIGHT THERAPEUTICS INC	COM	$952K	0.0%	56,000 SH	New
MBX BIOSCIENCES INC	COM	$124.1M	2.5%Prev: 1.6%	3,935,203 SH	Increased-67,684 SH
MIND MEDICINE MINDMED INC	COM NEW	$16.4M	0.3%Prev: 0.1%	1,226,700 SH	Increased+858,876 SH
MINERALYS THERAPEUTICS INC	COM	$35.6M	0.7%Prev: 1.3%	980,400 SH	Decreased-489,094 SH
NATERA INC	COM	$83.8M	1.7%Prev: 1.6%	365,800 SH	Increased-63,500 SH
NEUROCRINE BIOSCIENCES INC	COM	$44.6M	0.9%Prev: 1.2%	314,240 SH	Decreased-39,400 SH
NEUROPACE INC	COM	$37.2M	0.8%Prev: 0.6%	2,406,335 SH	Increased-207,849 SH
OCULAR THERAPEUTIX INC	COM	$1.9M	0.0%	157,300 SH	New
ORIC PHARMACEUTICALS INC	COM	$29.8M	0.6%Prev: 1.0%	3,641,756 SH	Decreased
PALISADE BIO INC	COM	$4.4M	0.1%	1,871,420 SH	New
PFIZER INC	COM	$41.2M	0.8%Prev: 0.3%	1,652,900 SH	Increased+1,152,900 SH
PHARVARIS N V	COM	$5.7M	0.1%	205,400 SH	New
PMV PHARMACEUTICALS INC	COM	$6.2M	0.1%Prev: 0.2%	4,975,291 SH	Decreased-1,000,000 SH
PRAXIS PRECISION MEDICINES I	COM NEW	$27.9M	0.6%	94,500 SH	New
PRELUDE THERAPEUTICS INC	COM	$31.6M	0.6%Prev: 0.4%	10,909,256 SH	Increased
PRELUDE THERAPEUTICS INC	NONVOTING	$16.5M	0.3%Prev: 0.2%	5,680,186 SH	Increased
PROTAGONIST THERAPEUTICS INC	COM	$1.9M	0.0%	21,700 SH	New
PTC THERAPEUTICS INC	COM	$1.8M	0.0%	23,200 SH	New
Q32 BIO INC	COM	$7.5M	0.2%Prev: 0.1%	2,252,987 SH	Increased
RAPT THERAPEUTICS INC	COM NEW	$55.6M	1.1%Prev: 0.7%	1,642,891 SH	Increased+556,273 SH
RELMADA THERAPEUTICS INC	COM	$12.6M	0.3%	2,610,600 SH	New
REPARE THERAPEUTICS INC	COM	$8.6M	0.2%Prev: 0.1%	3,322,488 SH	Increased
REVOLUTION MEDICINES INC	COM	$2.1M	0.0%	25,900 SH	New
RHYTHM PHARMACEUTICALS INC	COM	$25.7M	0.5%Prev: 0.5%	239,800 SH	Increased+24,648 SH
ROIVANT SCIENCES LTD	SHS	$47.5M	1.0%Prev: 1.0%	2,190,907 SH	Increased-523,891 SH
SHATTUCK LABS INC	COM	$23.0M	0.5%Prev: 0.4%	6,306,127 SH	Increased
SINOVAC BIOTECH LTD	SHS	$184.5M	3.8%Prev: 4.3%	2,718,735 SH
SIONNA THERAPEUTICS INC	COM	$146.5M	3.0%Prev: 2.6%	3,561,655 SH	Increased-143,304 SH
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	$80.8M	1.6%Prev: 0.7%	1,161,803 SH	Increased+22,503 SH
STRYKER CORPORATION	COM	$114.2M	2.3%Prev: 3.1%	325,000 SH	Decreased-34,200 SH
TARSUS PHARMACEUTICALS INC	COM	$12.6M	0.3%Prev: 0.3%	154,400 SH	Increased-43,500 SH
TECTONIC THERAPEUTIC INC	COM	$12.0M	0.2%	574,600 SH	New
TERNS PHARMACEUTICALS INC	COM	$87.0M	1.8%Prev: 1.3%	2,153,300 SH	Increased-5,409,671 SH
THE CIGNA GROUP	COM	$56.4M	1.2%Prev: 1.1%	205,000 SH	Increased+42,200 SH
THERMO FISHER SCIENTIFIC INC	COM	$26.9M	0.5%Prev: 0.5%	46,500 SH	Increased
TRAWS PHARMA INC	COM NEW	$684K	0.0%Prev: 0.0%	605,531 SH	Decreased
TREVI THERAPEUTICS INC	COM	$39.9M	0.8%Prev: 0.7%	3,190,700 SH	Increased-117,700 SH
UNIQURE NV	SHS	$17.6M	0.4%Prev: 0.6%	737,400 SH	Decreased+278,900 SH
UNITED THERAPEUTICS CORP DEL	COM	$51.3M	1.0%Prev: 1.1%	105,200 SH	Increased-9,700 SH
UPSTREAM BIO INC	COM	$154.6M	3.2%Prev: 2.5%	5,693,589 SH	Increased
UROGEN PHARMA LTD	COM	$20.5M	0.4%Prev: 0.3%	875,487 SH	Increased+186,487 SH
VERA THERAPEUTICS INC	CL A	$17.9M	0.4%	353,500 SH	New
VIR BIOTECHNOLOGY INC	COM	$14.4M	0.3%Prev: 0.3%	2,380,715 SH	Increased
VISTAGEN THERAPEUTICS INC	COM	$2.1M	0.0%Prev: 0.3%	3,105,200 SH	Decreased
WHITEHAWK THERAPEUTICS INC	COM	$10.1M	0.2%Prev: 0.2%	4,166,000 SH	Increased
XENON PHARMACEUTICALS INC	COM	$20.0M	0.4%Prev: 0.4%	447,200 SH	Increased+27,600 SH

Sold (vs prior filing)

ABBOTT LABS — $20.1M
ADICET BIO INC — $9.3M
AKERO THERAPEUTICS INC — $25.0M
AMYLYX PHARMACEUTICALS INC — $10.2M
ASTRAZENECA PLC — $11.5M
ATAI LIFE SCIENCES NV — $1.8M
CELCUITY INC — $2.7M
DIH HLDG US INC — $358K
EYEPOINT PHARMACEUTICALS INC — $25.6M
IMMATICS N.V — $4.0M
INTEGER HLDGS CORP — $30.0M
KEZAR LIFE SCIENCES INC — $752K
KORRO BIO INC — $1.6M
LYELL IMMUNOPHARMA INC — $840K
MILESTONE PHARMACEUTICALS IN — $6.4M
MURAL ONCOLOGY PUB LTD CO — $1.2M
PASSAGE BIO INC — $474K
SCHOLAR ROCK HLDG CORP — $3.7M
SCPHARMACEUTICALS INC — $34.4M
SI-BONE INC — $38.0M
… and 3 more

All filings

Open a filing on Jive Data

Filing Date	Quarter	Form	Accession	Portfolio	Filing
Feb 17, 2026	Q4 2025	13F-HR	0001172661-26-001119	$4.90B	View
Nov 14, 2025	Q3 2025	13F-HR	0001172661-25-005047	$4.26B	View
Aug 14, 2026	Q2 2026