| ABIVAX SA | SPONSORED ADS | $53.9M | 3.3%Prev: 3.2% | 400,000 SH | Increased-15,000 SH |
| ACADIA PHARMACEUTICALS INC | COM | $22.7M | 1.4% | 850,000 SH | New |
| ACLARIS THERAPEUTICS INC | COM | $1.8M | 0.1%Prev: 0.3% | 600,000 SH | Decreased-900,000 SH |
| AMYLYX PHARMACEUTICALS INC | COM | $11.5M | 0.7%Prev: 1.8% | 950,000 SH | Decreased-500,000 SH |
| APELLIS PHARMACEUTICALS INC | COM | $25.1M | 1.5%Prev: 2.0% | 1,000,000 SH | Increased |
| ARCELLX INC | COMMON STOCK | $7.5M | 0.5%Prev: 1.2% | 115,000 SH | Decreased-50,000 SH |
| ARCUS BIOSCIENCES INC | COM | $25.0M | 1.5% | 1,050,000 SH | New |
| AVIDITY BIOSCIENCES INC | COM | $36.1M | 2.2%Prev: 2.3% | 500,000 SH | Increased-100,000 SH |
| BIOGEN INC | COM | $35.2M | 2.1%Prev: 1.3% | 200,000 SH | Increased+100,000 SH |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | $9.5M | 0.6% | 350,000 SH | New |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $5.0M | 0.3%Prev: 1.1% | 200,000 SH | Decreased-325,000 SH |
| CG ONCOLOGY INC | COM | $8.3M | 0.5% | 200,000 SH | New |
| CIDARA THERAPEUTICS INC | COM NEW | $68.5M | 4.1%Prev: 3.2% | 310,000 SH | Increased-65,000 SH |
| COMPASS THERAPEUTICS INC | COM | $6.2M | 0.4%Prev: 0.6% | 1,150,000 SH | Decreased-900,000 SH |
| CORVUS PHARMACEUTICALS INC | COM | $3.9M | 0.2% | 500,000 SH | New |
| CRESCENT BIOPHARMA INC. | COM | $7.1M | 0.4%Prev: 0.6% | 600,000 SH | Decreased |
| CYTOKINETICS INC | COM NEW | $19.1M | 1.2% | 300,000 SH | New |
| DAY ONE BIOPHARMACEUTICALS I | COM | $2.8M | 0.2% | 300,000 SH | New |
| DBV TECHNOLOGIES S A | SPONSORED ADS | $479K | 0.0% | 25,000 SH | New |
| DESIGN THERAPEUTICS INC | COM | $23.4M | 1.4%Prev: 2.5% | 2,500,000 SH | Decreased-1,155,000 SH |
| DIANTHUS THERAPEUTICS INC | COM | $13.0M | 0.8%Prev: 0.7% | 315,000 SH | Increased+115,000 SH |
| DISC MEDICINE INC | COM | $40.5M | 2.4%Prev: 2.7% | 510,000 SH | Increased+60,000 SH |
| DYNE THERAPEUTICS INC | COM | $24.4M | 1.5%Prev: 2.7% | 1,250,000 SH | Decreased-1,150,000 SH |
| ENLIVEN THERAPEUTICS INC | COM | $5.2M | 0.3%Prev: 0.6% | 340,000 SH | Decreased |
| ERASCA INC | COM | $48.4M | 2.9%Prev: 3.0% | 13,000,000 SH | Increased-2,150,000 SH |
| FRACTYL HEALTH INC | COM | $2.4M | 0.1%Prev: 0.1% | 1,100,000 SH | Increased+600,000 SH |
| IBIO INC | COM NEW | $3.9M | 0.2% | 2,000,000 SH | New |
| IDEAYA BIOSCIENCES INC | COM | $123.6M | 7.5%Prev: 6.6% | 3,575,000 SH | Increased+875,000 SH |
| IMMATICS N.V | SHS | $8.9M | 0.5% | 850,000 SH | New |
| IMMIX BIOPHARMA INC | COM | $5.2M | 0.3% | 1,000,000 SH | New |
| IMMUNOCORE HLDGS PLC | ADS | $29.5M | 1.8%Prev: 2.8% | 850,000 SH | Decreased |
| IMMUNOVANT INC | COM | $35.0M | 2.1%Prev: 0.4% | 1,375,000 SH | Increased+1,100,000 SH |
| JADE BIOSCIENCES INC | COM NEW | $6.1M | 0.4%Prev: 0.5% | 395,000 SH | Increased-230,000 SH |
| JANUX THERAPEUTICS INC | COM | $13.8M | 0.8%Prev: 3.1% | 1,000,000 SH | Decreased-435,000 SH |
| JAZZ PHARMACEUTICALS PLC | SHS USD | $34.0M | 2.1%Prev: 2.4% | 200,000 SH | Increased |
| KINIKSA PHARMACEUTICALS INTL | ORD SHS CL A | $14.4M | 0.9% | 350,000 SH | New |
| KYMERA THERAPEUTICS INC | COM | $10.1M | 0.6%Prev: 1.3% | 130,000 SH | Decreased-120,000 SH |
| LB PHARMACEUTICALS INC | COM SHS | $26.7M | 1.6%Prev: 1.6% | 1,200,000 SH | Increased+70,000 SH |
| MAZE THERAPEUTICS INC | COM | $39.4M | 2.4%Prev: 2.9% | 950,000 SH | Increased-277,300 SH |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | $771K | 0.0%Prev: 0.1% | 1,850,000 SH | Decreased+1,350,000 SH |
| MINERVA NEUROSCIENCES INC | COM NEW | $13.3M | 0.8% | 3,311,000 SH | New |
| MIRUM PHARMACEUTICALS INC | COM | $17.8M | 1.1% | 225,000 SH | New |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | $23.1M | 1.4% | 1,750,000 SH | New |
| NEUROGENE INC | COM | $4.0M | 0.2% | 195,000 SH | New |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | $15.8M | 1.0% | 450,000 SH | New |
| NURIX THERAPEUTICS INC | COM | $9.5M | 0.6% | 500,000 SH | New |
| NUVATION BIO INC | *W EXP 02/10/202 | $22K | 0.0%Prev: 0.0% | 66,666 SH | Increased |
| OCULAR THERAPEUTIX INC | COM | $42.5M | 2.6%Prev: 3.4% | 3,500,000 SH | Increased+250,000 SH |
| OLEMA PHARMACEUTICALS INC | COM | $80.2M | 4.8%Prev: 2.8% | 3,208,875 SH | Increased |
| ORIC PHARMACEUTICALS INC | COM | $3.7M | 0.2% | 450,000 SH | New |
| PALATIN TECHNOLOGIES INC | COM NEW | $2.2M | 0.1% | 140,000 SH | New |
| PHARVARIS N V | COM | $2.8M | 0.2%Prev: 0.3% | 100,000 SH | Decreased-50,000 SH |
| PRAXIS PRECISION MEDICINES I | COM NEW | $110.5M | 6.7%Prev: 0.6% | 375,000 SH | Increased+250,000 SH |
| REVOLUTION MEDICINES INC | COM | $238.9M | 14.4%Prev: 11.5% | 3,000,000 SH | Increased+250,000 SH |
| RHYTHM PHARMACEUTICALS INC | COM | $20.3M | 1.2%Prev: 1.8% | 190,000 SH | Increased-10,000 SH |
| SEPTERNA INC | COM | $657K | 0.0%Prev: 0.1% | 23,548 SH | Decreased-60,000 SH |
| SOLENO THERAPEUTICS INC | COM | $13.9M | 0.8% | 300,000 SH | New |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $41.7M | 2.5%Prev: 2.1% | 600,000 SH | Increased-250,000 SH |
| TANGO THERAPEUTICS INC | COM | $37.2M | 2.2%Prev: 0.7% | 4,200,000 SH | Increased+3,250,000 SH |
| TERNS PHARMACEUTICALS INC | COM | $30.3M | 1.8% | 750,000 SH | New |
| TREVI THERAPEUTICS INC | COM | $19.4M | 1.2%Prev: 1.8% | 1,550,000 SH | Decreased-650,000 SH |
| TYRA BIOSCIENCES INC | COM | $5.5M | 0.3% | 210,000 SH | New |
| UNICYCIVE THERAPEUTICS INC | COM NEW | $2.7M | 0.2%Prev: 0.2% | 473,563 SH | Increased |
| UNIQURE NV | SHS | $16.2M | 1.0%Prev: 1.6% | 675,000 SH | Decreased+375,000 SH |
| VAXCYTE INC | COM | $30.0M | 1.8%Prev: 2.0% | 650,000 SH | Increased+25,000 SH |
| VERASTEM INC | COM NEW | $13.1M | 0.8%Prev: 3.2% | 1,700,000 SH | Decreased-2,350,000 SH |
| VOR BIOPHARMA INC | COM NEW | $1.3M | 0.1% | 100,000 SH | New |