HighVista Strategies LLC

CIK 0001335325 • 6 13F filings • May 15, 2025 – Aug 14, 2026

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Filer information

Filed by: HighVista Strategies LLC, Chief Compliance Officer
Address: 200 CLARENDON STREET, 50TH FLOOR, BOSTON, MA, 02116
Phone: 617-406-6546
AUM: $388.3M

AUM over time

$438.6M latest

Sector allocation over time

Past 5 quarters

Q4 2025

Q3 2025

Q2 2026

Q2 2025

Q1 2026

TechnologyConsumer DiscretionaryFinancialsOther

Holdings by filing

Portfolio value: $388.3M1 positionsView on SEC.gov

			% of Portfolio
3M CO	COM	$632K	0.2%Prev: 0.3%	3,950 SH	Decreased-3,650 SH
ABIVAX SA	SPONSORED ADS	$9.7M	2.5%Prev: 3.8%	72,185 SH	Decreased-112,283 SH
ACADIA HEALTHCARE COMPANY IN	COM	$1.2M	0.3%	81,630 SH	New
AFFIRM HLDGS INC	COM CL A	$974K	0.3%Prev: 0.2%	13,086 SH	Increased+586 SH
AGIOS PHARMACEUTICALS INC	COM	$4.0M	1.0%Prev: 1.9%	147,662 SH	Decreased-47,636 SH
ALCON AG	ORD SHS	$661K	0.2%Prev: 0.1%	10,440 SH	Increased+2,578 SH
ALKERMES PLC	SHS	$739K	0.2%Prev: 0.3%	26,401 SH	Decreased-17,680 SH
ALPHABET INC	CAP STK CL C	$2.0M	0.5%Prev: 0.6%	6,277 SH	Decreased-3,523 SH
AMAZON COM INC	COM	$4.0M	1.0%Prev: 1.4%	17,397 SH	Decreased-8,996 SH
AMPHENOL CORP NEW	CL A	$957K	0.2%Prev: 0.5%	7,081 SH	Decreased-8,319 SH
AMRIZE LTD	SHS	$1.8M	0.5%	33,468 SH	New
AMYLYX PHARMACEUTICALS INC	COM	$2.9M	0.7%	238,812 SH	New
APELLIS PHARMACEUTICALS INC	COM	$3.8M	1.0%Prev: 0.8%	150,776 SH	Increased+5,047 SH
API GROUP CORP	COM STK	$1.2M	0.3%Prev: 0.4%	30,958 SH	Decreased-16,392 SH
APOGEE THERAPEUTICS INC	COM	$6.7M	1.7%Prev: 1.0%	89,229 SH	Increased-17,878 SH
APPLOVIN CORP	COM CL A	$1.7M	0.4%	2,482 SH	New
ARCELLX INC	COMMON STOCK	$4.9M	1.3%Prev: 1.9%	75,002 SH	Decreased-21,175 SH
ARGAN INC	COM	$594K	0.2%Prev: 0.5%	1,896 SH	Decreased-5,204 SH
ARGENX SE	SPONSORED ADR	$3.0M	0.8%Prev: 0.7%	3,588 SH	Increased-480 SH
ASCENDIS PHARMA A/S	SPONSORED ADR	$780K	0.2%Prev: 0.3%	3,660 SH	Decreased-3,422 SH
AUTOLIV INC	COM	$622K	0.2%Prev: 0.3%	5,243 SH	Decreased-3,457 SH
AVALO THERAPEUTICS INC	COM NEW	$1.7M	0.4%Prev: 0.1%	95,631 SH	Increased+67,853 SH
AVIDITY BIOSCIENCES INC	COM	$2.9M	0.7%Prev: 0.7%	40,020 SH	Increased-25,560 SH
AXSOME THERAPEUTICS INC	COM	$2.0M	0.5%Prev: 0.3%	11,131 SH	Increased+1,783 SH
BANCO BRADESCO S A	SP ADR PFD NEW	$634K	0.2%Prev: 0.4%	190,264 SH	Decreased-329,836 SH
BOOKING HOLDINGS INC	COM	$1.3M	0.3%Prev: 0.2%	243 SH	Increased+86 SH
BRIDGEBIO ONCOLOGY THERAPEUT	COM NEW	$2.9M	0.7%	229,263 SH	New
BRIDGEBIO PHARMA INC	COM	$6.1M	1.6%Prev: 1.0%	80,205 SH	Increased-1,754 SH
BROADCOM INC	COM	$2.0M	0.5%Prev: 0.8%	5,639 SH	Decreased-4,561 SH
CELCUITY INC	COM	$1.6M	0.4%Prev: 0.2%	16,543 SH	Increased+2,863 SH
CELLDEX THERAPEUTICS INC NEW	COM NEW	$1.4M	0.4%Prev: 0.9%	51,805 SH	Decreased-83,453 SH
CENTESSA PHARMACEUTICALS PLC	SPONSORED ADS	$1.1M	0.3%Prev: 0.4%	44,490 SH	Decreased-18,811 SH
CG ONCOLOGY INC	COM	$1.2M	0.3%Prev: 0.3%	29,325 SH	Increased+3,285 SH
CIDARA THERAPEUTICS INC	COM NEW	$5.1M	1.3%Prev: 1.7%	22,928 SH	Decreased-47,976 SH
CIENA CORP	COM NEW	$1.2M	0.3%	5,185 SH	New
CLEAN HARBORS INC	COM	$1.5M	0.4%Prev: 0.5%	6,243 SH	Decreased-2,863 SH
CLEVELAND-CLIFFS INC NEW	COM	$1.6M	0.4%	118,574 SH	New
CNX RES CORP	COM	$648K	0.2%Prev: 0.2%	17,624 SH	Decreased-13,676 SH
COGENT BIOSCIENCES INC	COM	$12.0M	3.1%Prev: 1.6%	336,667 SH	Increased-125,738 SH
COMPANIA DE MINAS BUENAVENTU	SPONSORED ADR	$825K	0.2%Prev: 0.5%	29,649 SH	Decreased-53,282 SH
COMPASS PATHWAYS PLC	SPONSORED ADS	$3.4M	0.9%	498,933 SH	New
COMPASS THERAPEUTICS INC	COM	$1.3M	0.3%	245,532 SH	New
CONSTELLATION ENERGY CORP	COM	$1.7M	0.4%Prev: 0.6%	4,812 SH	Decreased-2,788 SH
CORE SCIENTIFIC INC NEW	COM	$925K	0.2%Prev: 0.3%	63,512 SH	Decreased-11,651 SH
CORPORACION AMER ARPTS S A	COM	$966K	0.2%Prev: 0.3%	37,145 SH	Decreased-34,255 SH
COUPANG INC	CL A	$585K	0.2%Prev: 0.2%	24,792 SH	Decreased+742 SH
CYTOKINETICS INC	COM NEW	$7.3M	1.9%Prev: 1.8%	114,564 SH	Decreased-18,366 SH
CYTOMX THERAPEUTICS INC	COM	$826K	0.2%Prev: 0.2%	193,941 SH	Increased-63,207 SH
DBV TECHNOLOGIES S A	SPONSORED ADS	$304K	0.1%	15,877 SH	New
DIANTHUS THERAPEUTICS INC	COM	$2.0M	0.5%Prev: 0.5%	48,484 SH	Decreased-5,741 SH
DYNE THERAPEUTICS INC	COM	$1.2M	0.3%	59,643 SH	New
EDGEWISE THERAPEUTICS INC	COM	$4.2M	1.1%Prev: 0.8%	171,137 SH	Increased-36,964 SH
ENLIVEN THERAPEUTICS INC	COM	$1.3M	0.3%Prev: 1.3%	82,536 SH	Decreased-176,599 SH
ENTERGY CORP NEW	COM	$955K	0.2%Prev: 0.2%	10,328 SH	Increased+728 SH
EQT CORP	COM	$1.5M	0.4%	27,090 SH	New
FERGUSON ENTERPRISES INC	COMMON STOCK NEW	$1.6M	0.4%Prev: 0.5%	6,973 SH	Decreased-2,705 SH
FLOWSERVE CORP	COM	$1.7M	0.4%Prev: 0.5%	24,958 SH	Decreased-14,017 SH
FULL TRUCK ALLIANCE CO LTD	SPONSORED ADS	$940K	0.2%	87,591 SH	New
GE VERNOVA INC	COM	$1.2M	0.3%Prev: 0.2%	1,768 SH	Increased+118 SH
GH RESEARCH PLC	ORDINARY SHARES	$3.1M	0.8%Prev: 0.8%	240,524 SH	Decreased-1,370 SH
GITLAB INC	CLASS A COM	$725K	0.2%	19,305 SH	New
GUARDANT HEALTH INC	COM	$3.8M	1.0%Prev: 1.0%	36,758 SH	Decreased-27,825 SH
HDFC BANK LTD	SPONSORED ADS	$809K	0.2%Prev: 0.3%	22,127 SH	Decreased-10,555 SH
HEWLETT PACKARD ENTERPRISE C	COM	$1.8M	0.5%Prev: 0.6%	76,181 SH	Decreased-22,519 SH
ICICI BANK LIMITED	ADR	$783K	0.2%Prev: 0.3%	26,284 SH	Decreased-10,763 SH
IMMUNOCORE HLDGS PLC	ADS	$1.1M	0.3%	32,998 SH	New
IMMUNOVANT INC	COM	$5.6M	1.5%Prev: 1.0%	221,883 SH	Increased-31,244 SH
INSMED INC	COM PAR $.01	$6.9M	1.8%Prev: 1.8%	39,400 SH	Decreased-10,549 SH
INTUIT	COM	$1.2M	0.3%Prev: 0.4%	1,813 SH	Decreased-350 SH
INVESCO DB COMMDY INDX TRCK	UNIT	$23.6M	6.1%Prev: 7.9%	1,057,238 SH	Decreased-378,898 SH
JANUX THERAPEUTICS INC	COM	$572K	0.1%Prev: 0.3%	41,443 SH	Decreased-13,807 SH
JD.COM INC	SPON ADS CL A	$501K	0.1%Prev: 0.2%	17,463 SH	Decreased-5,920 SH
KANZHUN LIMITED	SPONSORED ADS	$420K	0.1%Prev: 0.1%	20,598 SH	Decreased+1,698 SH
KBR INC	COM	$1.2M	0.3%Prev: 0.4%	30,006 SH	Decreased-5,494 SH
KYMERA THERAPEUTICS INC	COM	$532K	0.1%Prev: 0.2%	6,835 SH	Decreased-8,893 SH
LB PHARMACEUTICALS INC	COM SHS	$3.1M	0.8%	140,107 SH	New
LIQUIDIA CORPORATION	COM NEW	$5.4M	1.4%Prev: 1.0%	156,003 SH	Increased-20,482 SH
LUMENTUM HLDGS INC	COM	$1.6M	0.4%Prev: 0.5%	4,317 SH	Decreased-8,610 SH
MADRIGAL PHARMACEUTICALS INC	COM	$1.7M	0.4%Prev: 0.4%	2,839 SH	Increased-698 SH
MASTEC INC	COM	$1.1M	0.3%Prev: 0.3%	5,027 SH	Decreased-1,673 SH
MASTERCARD INCORPORATED	CL A	$1.6M	0.4%Prev: 0.6%	2,784 SH	Decreased-1,421 SH
MAZE THERAPEUTICS INC	COM	$7.1M	1.8%	170,353 SH	New
MERCADOLIBRE INC	COM	$937K	0.2%Prev: 0.3%	465 SH	Decreased-35 SH
META PLATFORMS INC	CL A	$1.7M	0.4%Prev: 0.8%	2,562 SH	Decreased-1,938 SH
MICROSOFT CORP	COM	$3.2M	0.8%Prev: 1.2%	6,537 SH	Decreased-2,921 SH
MINERALYS THERAPEUTICS INC	COM	$4.5M	1.2%Prev: 2.0%	124,544 SH	Decreased-85,285 SH
NEKTAR THERAPEUTICS	COM NEW	$497K	0.1%	11,749 SH	New
NEW ORIENTAL ED & TECHNOLOGY	SPON ADR	$705K	0.2%	12,817 SH	New
NEWAMSTERDAM PHARMA COMPANY	ORDINARY SHARES	$1.2M	0.3%Prev: 0.2%	35,586 SH	Increased+3,755 SH
NEXTERA ENERGY INC	COM	$1.5M	0.4%Prev: 0.3%	19,285 SH	Increased+3,533 SH
NOKIA CORP	SPONSORED ADR	$385K	0.1%Prev: 0.1%	59,524 SH	Decreased-23,376 SH
NU HLDGS LTD	ORD SHS CL A	$1.0M	0.3%Prev: 0.4%	62,570 SH	Decreased-46,767 SH
NUVALENT INC	COM	$7.4M	1.9%Prev: 2.0%	73,287 SH	Decreased-20,007 SH
NVIDIA CORPORATION	COM	$2.7M	0.7%Prev: 0.6%	14,220 SH	Increased+820 SH
OCULAR THERAPEUTIX INC	COM	$4.2M	1.1%Prev: 0.3%	344,067 SH	Increased+237,456 SH
OLEMA PHARMACEUTICALS INC	COM	$6.0M	1.6%Prev: 1.0%	241,489 SH	Increased-195,690 SH
ORTHOFIX MED INC	COM	$1.3M	0.3%Prev: 0.3%	85,049 SH	Decreased-8,151 SH
PALISADE BIO INC	COM	$3.1M	0.8%	1,300,031 SH	New
PENNYMAC FINL SVCS INC NEW	COM	$1.0M	0.3%Prev: 0.3%	7,806 SH	Decreased-531 SH
PETROLEO BRASILEIRO SA PETRO	SP ADR NON VTG	$622K	0.2%Prev: 0.4%	55,200 SH	Decreased-83,000 SH
PHARVARIS N V	COM	$4.5M	1.2%	162,370 SH	New
PRAXIS PRECISION MEDICINES I	COM NEW	$7.6M	2.0%Prev: 1.2%	25,841 SH	Increased-69,161 SH
PROTAGONIST THERAPEUTICS INC	COM	$6.4M	1.7%Prev: 2.0%	73,545 SH	Decreased-48,137 SH
PTC INC	COM	$1.1M	0.3%Prev: 0.5%	6,374 SH	Decreased-3,148 SH
PURE STORAGE INC	CL A	$1.2M	0.3%Prev: 0.4%	17,409 SH	Decreased-2,991 SH
QXO INC	COM NEW	$1.1M	0.3%Prev: 0.4%	58,720 SH	Decreased-31,480 SH
RBC BEARINGS INC	COM	$1.2M	0.3%Prev: 0.3%	2,703 SH	Decreased-797 SH
REDDIT INC	CL A	$1.2M	0.3%Prev: 0.4%	5,300 SH	Decreased-1,000 SH
RELAY THERAPEUTICS INC	COM	$4.6M	1.2%Prev: 0.3%	545,079 SH	Increased+304,620 SH
REVOLUTION MEDICINES INC	COM	$9.6M	2.5%Prev: 2.0%	120,240 SH	Increased-55,208 SH
RHYTHM PHARMACEUTICALS INC	COM	$4.6M	1.2%Prev: 0.9%	42,867 SH	Increased+5,385 SH
ROBLOX CORP	CL A	$683K	0.2%Prev: 0.3%	8,431 SH	Decreased-269 SH
ROCKET COS INC	COM CL A	$1.9M	0.5%	97,430 SH	New
RXO INC	COMMON STOCK	$1.1M	0.3%Prev: 0.3%	90,938 SH	Decreased+10,038 SH
SALESFORCE INC	COM	$2.3M	0.6%Prev: 0.7%	8,613 SH	Decreased-4,272 SH
SANDISK CORP	COM	$1.0M	0.3%Prev: 1.3%	4,378 SH	Decreased-43,073 SH
SCHWAB CHARLES CORP	COM	$1.1M	0.3%Prev: 0.3%	10,601 SH	Decreased-3,499 SH
SEA LTD	SPONSORD ADS	$950K	0.2%Prev: 0.2%	7,450 SH	Increased+2,309 SH
SEPTERNA INC	COM	$2.2M	0.6%	78,682 SH	New
SHIFT4 PMTS INC	CL A	$817K	0.2%Prev: 0.2%	12,982 SH	Decreased+482 SH
SOLENO THERAPEUTICS INC	COM	$6.3M	1.6%Prev: 0.3%	135,069 SH	Increased+116,369 SH
SPYRE THERAPEUTICS INC	COM NEW	$6.2M	1.6%Prev: 0.9%	188,206 SH	Increased-27,540 SH
STOKE THERAPEUTICS INC	COM	$3.7M	0.9%	115,539 SH	New
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	$13.4M	3.5%Prev: 1.6%	193,001 SH	Increased-43,235 SH
TALEN ENERGY CORP	COM	$1.3M	0.3%Prev: 0.5%	3,488 SH	Decreased-1,612 SH
TARSUS PHARMACEUTICALS INC	COM	$4.4M	1.1%Prev: 0.4%	53,564 SH	Increased+28,710 SH
TERNS PHARMACEUTICALS INC	COM	$7.1M	1.8%	175,462 SH	New
THERMO FISHER SCIENTIFIC INC	COM	$1.3M	0.3%	2,269 SH	New
TRANSDIGM GROUP INC	COM	$2.9M	0.7%	2,175 SH	New
TREVI THERAPEUTICS INC	COM	$1.3M	0.3%	106,159 SH	New
TRIP COM GROUP LTD	ADS	$766K	0.2%Prev: 0.2%	10,646 SH	Increased+890 SH
TYRA BIOSCIENCES INC	COM	$922K	0.2%Prev: 0.2%	35,086 SH	Increased-30,726 SH
UNIFIRST CORP MASS	COM	$1.5M	0.4%	7,727 SH	New
UNION PAC CORP	COM	$1.9M	0.5%	8,058 SH	New
UNITED THERAPEUTICS CORP DEL	COM	$1.1M	0.3%	2,330 SH	New
UNITY SOFTWARE INC	COM	$1.3M	0.3%Prev: 0.7%	28,663 SH	Decreased-38,566 SH
UROGEN PHARMA LTD	COM	$656K	0.2%Prev: 0.2%	28,005 SH	Increased-3,881 SH
VAXCYTE INC	COM	$5.3M	1.4%Prev: 0.8%	114,049 SH	Increased+27,247 SH
VIRIDIAN THERAPEUTICS INC	COM	$11.6M	3.0%Prev: 2.5%	372,472 SH	Increased-96,863 SH
VISA INC	COM CL A	$2.2M	0.6%Prev: 0.7%	6,291 SH	Decreased-1,570 SH
VISTRA CORP	COM	$915K	0.2%	5,673 SH	New
WORKDAY INC	CL A	$1.4M	0.4%Prev: 0.5%	6,486 SH	Decreased-1,705 SH
XCEL ENERGY INC	COM	$595K	0.2%	8,058 SH	New
XOMA ROYALTY CORPORATION	COM NEW	$3.0M	0.8%Prev: 1.0%	112,917 SH	Decreased+7,203 SH
XPO INC	COM	$1.7M	0.4%Prev: 0.7%	12,723 SH	Decreased-8,357 SH

Sold (vs prior filing)

ADMA BIOLOGICS INC — $1.4M
ADVANCED MICRO DEVICES INC — $2.8M
AKERO THERAPEUTICS INC — $5.2M
ALIBABA GROUP HLDG LTD — $671K
AURA BIOSCIENCES INC — $168K
AVANTOR INC — $2.2M
BANK AMERICA CORP — $1.4M
CAESARS ENTERTAINMENT INC NE — $1.2M
CAPITAL ONE FINL CORP — $2.1M
CISCO SYS INC — $1.5M
CORBUS PHARMACEUTICALS HLDGS — $1.5M
CORE & MAIN INC — $1.5M
CRH PLC — $2.3M
DYNAVAX TECHNOLOGIES CORP — $1.9M
ENTEGRIS INC — $1.5M
EVOLUS INC — $1.4M
FABRINET — $1.9M
INHIBRX BIOSCIENCES INC — $257K
JOHNSON CTLS INTL PLC — $1.2M
KE HLDGS INC — $217K
… and 16 more

All filings

Open a filing on Jive Data

Filing Date	Quarter	Form	Accession	Portfolio	Filing
Feb 17, 2026	Q4 2025	13F-HR	0001172661-26-000882	$388.3M	View
Nov 14, 2025	Q3 2025	13F-HR	0001172661-25-004799	$408.0M	View
Aug 14, 2026	Q2 2026