| AARDVARK THERAPEUTICS INC | COM | $208K | 0.0% | 15,882 SH | New |
| ABIVAX SA | SPONSORED ADS | $10.2M | 1.8%Prev: 0.9% | 75,644 SH | Increased+34,024 SH |
| ALNYLAM PHARMACEUTICALS INC | COM | $2.1M | 0.4%Prev: 1.2% | 5,341 SH | Decreased-4,659 SH |
| ALTIMMUNE INC | COM NEW | $1.8M | 0.3%Prev: 0.4% | 491,800 SH | Increased+28,800 SH |
| ANAVEX LIFE SCIENCES CORP | COM NEW | $501K | 0.1%Prev: 0.3% | 140,600 SH | Decreased+800 SH |
| ANI PHARMACEUTICALS INC | COM | $4.2M | 0.7%Prev: 0.7% | 53,354 SH | Increased+21,954 SH |
| ANNEXON INC | COM | $3.3M | 0.6% | 659,100 SH | New |
| APOGEE THERAPEUTICS INC | COM | $15.9M | 2.7%Prev: 1.9% | 211,100 SH | Increased+19,450 SH |
| APPLIED THERAPEUTICS INC | COM | $2K | 0.0%Prev: 0.0% | 20,200 SH | Decreased+1,200 SH |
| AQUESTIVE THERAPEUTICS INC | COM | $3.5M | 0.6% | 548,800 SH | New |
| ARBUTUS BIOPHARMA CORP | COM | $2.6M | 0.5%Prev: 0.6% | 548,600 SH | Increased+32,300 SH |
| ARDELYX INC | COM | $1.5M | 0.3%Prev: 0.6% | 252,198 SH | Decreased-147,802 SH |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $1.5M | 0.3%Prev: 1.4% | 6,840 SH | Decreased-20,732 SH |
| ATYR PHARMA INC | COM NEW | $21K | 0.0%Prev: 0.0% | 27,300 SH | Decreased-177,600 SH |
| AVIDITY BIOSCIENCES INC | COM | $23.7M | 4.1%Prev: 2.6% | 328,000 SH | Increased+97,900 SH |
| AYTU BIOPHARMA INC | COM | $795K | 0.1%Prev: 0.1% | 305,788 SH | Increased+33,118 SH |
| BEONE MEDICINES LTD | SPONSORED ADS | $173K | 0.0% | 7,500 SH | New |
| BIOAGE LABS INC | COM | $3.9M | 0.7% | 293,764 SH | New |
| BIOCRYST PHARMACEUTICALS INC | COM | $1.5M | 0.3% | 190,928 SH | New |
| BIOHAVEN LTD | COM | $2.3M | 0.4% | 200,000 SH | New |
| BIOMARIN PHARMACEUTICAL INC | COM | $8.7M | 1.5%Prev: 2.9% | 146,361 SH | Decreased-66,516 SH |
| BLACK DIAMOND THERAPEUTICS I | COM | $463K | 0.1% | 190,400 SH | New |
| BRIDGEBIO PHARMA INC | COM | $31.3M | 5.4%Prev: 1.7% | 409,600 SH | Increased+278,200 SH |
| CAPRICOR THERAPEUTICS INC | COM NEW | $19.3M | 3.3%Prev: 0.6% | 670,375 SH | Increased+370,375 SH |
| CASSAVA SCIENCES INC | COM | $21K | 0.0%Prev: 0.0% | 10,600 SH | Decreased+700 SH |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $2.8M | 0.5% | 111,100 SH | New |
| COGENT BIOSCIENCES INC | COM | $4.7M | 0.8%Prev: 1.1% | 131,852 SH | Increased-165,961 SH |
| CORCEPT THERAPEUTICS INC | COM | $8.1M | 1.4%Prev: 0.6% | 232,245 SH | Increased+205,745 SH |
| CORMEDIX INC | COM | $1.8M | 0.3%Prev: 0.3% | 159,000 SH | Increased+59,000 SH |
| CORVUS PHARMACEUTICALS INC | COM | $409K | 0.1%Prev: 0.1% | 53,100 SH | Increased+3,100 SH |
| CRISPR THERAPEUTICS AG | NAMEN AKT | $5.9M | 1.0%Prev: 1.9% | 112,700 SH | Decreased+700 SH |
| DESIGN THERAPEUTICS INC | COM | $941K | 0.2% | 100,320 SH | New |
| EDESA BIOTECH INC | COM NEW | $77K | 0.0% | 54,025 SH | New |
| EDGEWISE THERAPEUTICS INC | COM | $744K | 0.1% | 30,000 SH | New |
| EDITAS MEDICINE INC | COM | $653K | 0.1%Prev: 0.3% | 318,700 SH | Decreased+18,700 SH |
| ELI LILLY & CO | COM | $2.1M | 0.4%Prev: 2.0% | 2,000 SH | Decreased-8,000 SH |
| ENANTA PHARMACEUTICALS INC | COM | $1.0M | 0.2% | 65,138 SH | New |
| EQUILLIUM INC | COM | $538K | 0.1%Prev: 0.1% | 347,393 SH | Increased+47,393 SH |
| EVOLUS INC | COM | $790K | 0.1% | 118,800 SH | New |
| FOGHORN THERAPEUTICS INC | COM | $165K | 0.0%Prev: 0.1% | 30,630 SH | Decreased-19,370 SH |
| GOSSAMER BIO INC | COM | $2.7M | 0.5%Prev: 0.6% | 877,100 SH | Increased+52,300 SH |
| HARMONY BIOSCIENCES HLDGS IN | COM | $281K | 0.0%Prev: 1.8% | 7,500 SH | Decreased-242,600 SH |
| IMMUNOCORE HLDGS PLC | ADS | $2.4M | 0.4%Prev: 1.2% | 70,300 SH | Decreased-54,084 SH |
| IMMUNOME INC | COM | $483K | 0.1% | 22,500 SH | New |
| INCYTE CORP | COM | $9.9M | 1.7%Prev: 2.2% | 100,000 SH | Increased |
| INDIVIOR PLC | ORD | $8.5M | 1.5%Prev: 1.6% | 237,620 SH | Increased-16,632 SH |
| INHIBRX BIOSCIENCES INC | COM | $103K | 0.0% | 1,299 SH | New |
| INOVIO PHARMACEUTICALS INC | COM SHS | $1.1M | 0.2% | 633,682 SH | New |
| INSMED INC | COM PAR $.01 | $9.2M | 1.6% | 52,800 SH | New |
| INTELLIA THERAPEUTICS INC | COM | $4.8M | 0.8%Prev: 2.1% | 529,300 SH | Decreased+59,100 SH |
| INVENTIVA SA | ADS | $1.6M | 0.3% | 334,251 SH | New |
| INVESCO QQQ TR | UNIT SER 1 | $18.4M | 3.2% | 30,000 SH | New |
| IONIS PHARMACEUTICALS INC | COM | $8.4M | 1.4%Prev: 1.7% | 106,200 SH | Increased+6,200 SH |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | $2.3M | 0.4% | 683,611 SH | New |
| JADE BIOSCIENCES INC | COM NEW | $3K | 0.0%Prev: 0.0% | 1,046 SH | Increased |
| JANUX THERAPEUTICS INC | COM | $414K | 0.1% | 30,000 SH | New |
| JAZZ PHARMACEUTICALS PLC | SHS USD | $17.9M | 3.1%Prev: 5.8% | 105,300 SH | Decreased-67,840 SH |
| JOHNSON & JOHNSON | COM | $24.1M | 4.2% | 116,444 SH | New |
| KODIAK SCIENCES INC | COM | $828K | 0.1%Prev: 0.1% | 29,600 SH | Increased+700 SH |
| LEGEND BIOTECH CORP | SPONSORED ADS | $1.5M | 0.3% | 69,000 SH | New |
| LIGAND PHARMACEUTICALS INC | COM NEW | $565K | 0.1% | 2,987 SH | New |
| LIPOCINE INC NEW | COM NEW | $2.1M | 0.4% | 260,939 SH | New |
| LIQUIDIA CORPORATION | COM NEW | $755K | 0.1% | 21,881 SH | New |
| LYELL IMMUNOPHARMA INC | COM NEW | $117K | 0.0% | 3,800 SH | New |
| MANNKIND CORP | COM NEW | $4.8M | 0.8%Prev: 1.7% | 854,300 SH | Decreased-397,675 SH |
| MAPLIGHT THERAPEUTICS INC | COM | $1.1M | 0.2% | 63,791 SH | New |
| MEREO BIOPHARMA GROUP PLC | SPON ADS | $833K | 0.1%Prev: 0.8% | 1,999,500 SH | Decreased+439,900 SH |
| MINERALYS THERAPEUTICS INC | COM | $907K | 0.2% | 25,000 SH | New |
| MONTE ROSA THERAPEUTICS INC | COM | $977K | 0.2% | 62,281 SH | New |
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | $622K | 0.1%Prev: 0.0% | 47,200 SH | Increased+21,100 SH |
| NEUPHORIA THERAPEUTICS INC | COM | $194K | 0.0%Prev: 0.1% | 50,000 SH | Decreased+28,548 SH |
| NOVO-NORDISK A S | ADR | $2.7M | 0.5%Prev: 1.8% | 53,100 SH | Decreased-71,900 SH |
| OCULAR THERAPEUTIX INC | COM | $6.6M | 1.1%Prev: 0.4% | 545,200 SH | Increased+408,500 SH |
| OLEMA PHARMACEUTICALS INC | COM | $2.4M | 0.4%Prev: 0.2% | 96,100 SH | Increased+5,600 SH |
| PACIRA BIOSCIENCES INC | COM | $1.2M | 0.2%Prev: 0.4% | 48,025 SH | Decreased-10,901 SH |
| PALISADE BIO INC | COM | $390K | 0.1% | 166,049 SH | New |
| PELTHOS THERAPEUTICS INC | COM SHS | $775K | 0.1%Prev: 0.1% | 25,000 SH | Increased+14,502 SH |
| PLIANT THERAPEUTICS INC | COM | $177K | 0.0% | 144,914 SH | New |
| PRAXIS PRECISION MEDICINES I | COM NEW | $29.7M | 5.1%Prev: 1.4% | 100,600 SH | Increased+600 SH |
| PROQR THRAPEUTICS N V | SHS EURO | $338K | 0.1%Prev: 0.1% | 167,532 SH | Increased+9,838 SH |
| PROTAGONIST THERAPEUTICS INC | COM | $2.0M | 0.3%Prev: 0.9% | 22,700 SH | Decreased-28,485 SH |
| PROTHENA CORP PLC | SHS | $1.0M | 0.2% | 106,539 SH | New |
| PUMA BIOTECHNOLOGY INC | COM | $201K | 0.0%Prev: 0.2% | 33,800 SH | Decreased-102,100 SH |
| PURETECH HEALTH PLC | ADS | $124K | 0.0%Prev: 0.0% | 7,442 SH | Decreased+118 SH |
| RECURSION PHARMACEUTICALS IN | CL A | $3.0M | 0.5%Prev: 0.9% | 741,900 SH | Decreased+43,500 SH |
| REGENERON PHARMACEUTICALS | COM | $11.8M | 2.0%Prev: 4.3% | 15,300 SH | Decreased-14,860 SH |
| RELMADA THERAPEUTICS INC | COM | $1.9M | 0.3% | 389,395 SH | New |
| REPLIMUNE GROUP INC | COM | $2.2M | 0.4%Prev: 0.7% | 230,997 SH | Decreased-381,303 SH |
| REVIVA PHARMACEUTCLS HLDGS I | COM | $140K | 0.0%Prev: 0.2% | 500,000 SH | Decreased-2,006,921 SH |
| REVOLUTION MEDICINES INC | COM | $2.9M | 0.5%Prev: 0.7% | 37,020 SH | Increased-22,059 SH |
| RIGEL PHARMACEUTICALS INC | COM | $1.3M | 0.2% | 30,000 SH | New |
| ROIVANT SCIENCES LTD | SHS | $6.9M | 1.2%Prev: 1.6% | 318,700 SH | Increased-101,300 SH |
| SELLAS LIFE SCIENCES GROUP I | COM NEW | $1.6M | 0.3%Prev: 0.2% | 424,900 SH | Increased+24,900 SH |
| SOLENO THERAPEUTICS INC | COM | $3.7M | 0.6%Prev: 5.7% | 79,992 SH | Decreased-247,338 SH |
| SPDR SERIES TRUST | STATE STREET SPD | $30.5M | 5.3% | 250,000 SH | New |
| STOKE THERAPEUTICS INC | COM | $545K | 0.1% | 17,181 SH | New |
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | $13.3M | 2.3% | 191,700 SH | New |
| TALPHERA INC | COM NEW | $156K | 0.0% | 136,923 SH | New |
| TECTONIC THERAPEUTIC INC | COM | $2.1M | 0.4%Prev: 0.4% | 100,600 SH | Increased+600 SH |
| TENAX THERAPEUTICS INC | COM NEW | $3.0M | 0.5% | 243,170 SH | New |
| TERNS PHARMACEUTICALS INC | COM | $16.6M | 2.9%Prev: 1.1% | 410,580 SH | Increased-137,779 SH |
| TG THERAPEUTICS INC | COM | $6.7M | 1.1%Prev: 0.6% | 223,283 SH | Increased+162,535 SH |
| TRAVERE THERAPEUTICS INC | COM | $1.9M | 0.3%Prev: 0.0% | 50,300 SH | Increased+50,000 SH |
| TREVI THERAPEUTICS INC | COM | $1.2M | 0.2%Prev: 0.2% | 97,184 SH | Increased+11,354 SH |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $2.3M | 0.4%Prev: 2.2% | 100,000 SH | Decreased-182,489 SH |
| UNIQURE NV | SHS | $8.3M | 1.4%Prev: 4.5% | 346,800 SH | Decreased+46,800 SH |
| UNITED THERAPEUTICS CORP DEL | COM | $4.9M | 0.8% | 10,000 SH | New |
| UPSTREAM BIO INC | COM | $557K | 0.1%Prev: 1.0% | 20,500 SH | Decreased-179,500 SH |
| UROGEN PHARMA LTD | COM | $511K | 0.1%Prev: 0.5% | 21,810 SH | Decreased-68,190 SH |
| VANDA PHARMACEUTICALS INC | COM | $1.8M | 0.3% | 200,000 SH | New |
| VAXCYTE INC | COM | $1.1M | 0.2%Prev: 2.0% | 22,972 SH | Decreased-195,313 SH |
| VENTYX BIOSCIENCES INC | COM | $1.8M | 0.3%Prev: 0.1% | 200,000 SH | Increased+128,796 SH |
| VERTEX PHARMACEUTICALS INC | COM | $44.6M | 7.7% | 98,300 SH | New |
| VIKING THERAPEUTICS INC | COM | $47.2M | 8.1%Prev: 4.0% | 1,342,449 SH | Increased+743,660 SH |
| VIR BIOTECHNOLOGY INC | COM | $1.1M | 0.2% | 189,200 SH | New |
| VIRIDIAN THERAPEUTICS INC | COM | $657K | 0.1% | 21,114 SH | New |
| VISTAGEN THERAPEUTICS INC | COM | $137K | 0.0%Prev: 0.4% | 206,500 SH | Decreased-243,489 SH |
| XERIS BIOPHARMA HOLDINGS INC | COM | $1.3M | 0.2%Prev: 0.2% | 170,568 SH | Increased+95,815 SH |
| ZYMEWORKS INC | COM | $6.9M | 1.2%Prev: 0.9% | 262,000 SH | Increased+65,500 SH |