| 4D Molecular Therapeutics, Inc. | COM | $3.6M | 0.0% | 475,737 SH | New |
| AbCellera Biologics Inc. | COM | $94.1M | 0.6%Prev: 1.0% | 27,525,640 SH | Decreased |
| Abivax S.A. | SPONSORED ADS | $118.1M | 0.7%Prev: 0.5% | 875,796 SH | Increased |
| Absci Corporation | COM | $7.5M | 0.0% | 2,134,803 SH | New |
| ACADIA Pharmaceuticals Inc. | COM | $1.15B | 6.7%Prev: 6.6% | 42,896,690 SH | Increased |
| Acrivon Therapeutics, Inc. | COMMON STOCK | $55K | 0.0%Prev: 0.0% | 22,809 SH | Increased |
| Aligos Therapeutics, Inc. | COM | $774K | 0.0%Prev: 0.0% | 83,055 SH | Decreased |
| Alkermes plc | SHS | $280.1M | 1.6%Prev: 1.8% | 10,012,267 SH | Increased+1,920,916 SH |
| Alumis Inc. | COM | $15.3M | 0.1%Prev: 0.0% | 1,562,500 SH | Increased |
| Arcus Biosciences, Inc. | COM | $6.4M | 0.0% | 270,000 SH | New |
| argenx SE | SPONSORED ADR | $21.2M | 0.1%Prev: 0.2% | 25,174 SH | Decreased-12,586 SH |
| Arrowhead Pharmaceuticals, Inc. | COM | $144.4M | 0.8%Prev: 0.4% | 2,175,645 SH | Increased+504,883 SH |
| BeOne Medicines Ltd. | SPONSORED ADS | $2.67B | 15.7%Prev: 21.7% | 8,799,053 SH | Decreased |
| Bicycle Therapeutics plc | SPONSORED ADS | $77.1M | 0.5%Prev: 0.6% | 10,885,357 SH | Decreased |
| BioCryst Pharmaceuticals, Inc. | COM | $22.0M | 0.1% | 2,822,727 SH | New |
| BioNTech SE | SPONSORED ADS | $35.1M | 0.2%Prev: 0.3% | 368,923 SH | Decreased |
| Celcuity Inc. | COM | $789.5M | 4.6%Prev: 2.8% | 7,915,792 SH | Increased |
| Celcuity Inc. | Note 2.75% 8/1/2031 | $66.6M | 0.4%Prev: 0.3% | 30,750,000 PRN | Increased |
| Celldex Therapeutics, Inc. | COM | $18.1M | 0.1%Prev: 0.1% | 665,370 SH | Increased |
| Centessa Pharmaceuticals plc | SPONSORED ADS | $16.8M | 0.1% | 670,751 SH | New |
| Cerus Corporation | COM | $20.6M | 0.1%Prev: 0.1% | 10,008,345 SH | Increased |
| Contineum Therapeutics, Inc. | CL A | $16.2M | 0.1%Prev: 0.0% | 1,420,838 SH | Increased+1,343,168 SH |
| Crinetics Pharmaceuticals, Inc. | COM | $76.8M | 0.4%Prev: 0.1% | 1,648,869 SH | Increased+1,368,869 SH |
| CytomX Therapeutics, Inc. | COM | $18.1M | 0.1%Prev: 0.1% | 4,250,826 SH | Increased |
| DBV Technologies S.A. | SPONSORED ADS | $28.0M | 0.2%Prev: 0.1% | 1,461,425 SH | Increased |
| Denali Therapeutics Inc. | COM | $61.6M | 0.4%Prev: 0.4% | 3,731,695 SH | Increased |
| Design Therapeutics, Inc. | COM | $20.9M | 0.1%Prev: 0.1% | 2,233,099 SH | Increased+520,217 SH |
| Dianthus Therapeutics, Inc. | COM | $32.5M | 0.2%Prev: 0.2% | 789,759 SH | Increased |
| Disc Medicine, Inc. | COM | $26.8M | 0.2%Prev: 0.2% | 337,050 SH | Increased |
| Dyne Therapeutics, Inc. | COM | $15.9M | 0.1% | 813,449 SH | New |
| Edgewise Therapeutics, Inc. | COM | $163.2M | 1.0%Prev: 0.9% | 6,575,940 SH | Increased-730,000 SH |
| Enliven Therapeutics, Inc. | COM | $4.2M | 0.0%Prev: 0.0% | 271,406 SH | Increased+156,573 SH |
| Entrada Therapeutics, Inc. | COM | $52.1M | 0.3%Prev: 0.2% | 5,072,730 SH | Increased+206,911 SH |
| GRAIL, Inc. | COM | $178.5M | 1.0%Prev: 0.7% | 2,085,333 SH | Increased+455,208 SH |
| IDEAYA Biosciences, Inc. | COM | $125.1M | 0.7%Prev: 0.6% | 3,618,826 SH | Increased+343,382 SH |
| Immatics N.V. | SHS | $127.0M | 0.7%Prev: 0.7% | 12,094,094 SH | Increased |
| Immunocore Holdings plc | ADS | $80.6M | 0.5%Prev: 0.6% | 2,322,656 SH | Decreased |
| Immunovant, Inc. | COM | $138.7M | 0.8%Prev: 0.6% | 5,457,881 SH | Increased |
| Incyte Corporation | COM | $3.04B | 17.8%Prev: 18.8% | 30,743,991 SH | Increased+328 SH |
| Insmed Incorporated | COM PAR $.01 | $1.15B | 6.7%Prev: 7.0% | 6,592,746 SH | Increased-110,738 SH |
| Ionis Pharmaceuticals, Inc. | COM | $141.8M | 0.8%Prev: 0.3% | 1,791,841 SH | Increased+1,225,043 SH |
| Jade Biosciences, Inc. | COM | $25.3M | 0.1% | 1,641,137 SH | New |
| KALA BIO, Inc. | COM | $1.0M | 0.0%Prev: 0.0% | 1,804,055 SH | Decreased+818,962 SH |
| Kiniksa Pharmaceuticals International, plc | ORD SHS CL A | $116.6M | 0.7%Prev: 0.8% | 2,826,246 SH | Increased+1,577 SH |
| Kodiak Sciences Inc. | COM | $556.9M | 3.3%Prev: 2.0% | 19,919,186 SH | Increased+2,608,696 SH |
| Kymera Therapeutics, Inc. | COM | $673.6M | 3.9%Prev: 2.7% | 8,657,242 SH | Increased+2,005,813 SH |
| LB Pharmaceuticals Inc. | COM SHS | $4.5M | 0.0%Prev: 0.0% | 200,000 SH | Increased |
| Madrigal Pharmaceuticals, Inc. | COM | $1.25B | 7.3%Prev: 7.1% | 2,141,701 SH | Increased |
| MapLight Therapeutics, Inc. | COM | $6.4M | 0.0% | 364,705 SH | New |
| Monte Rosa Therapeutics, Inc. | COM | $68.1M | 0.4%Prev: 0.3% | 4,345,736 SH | Increased-570,359 SH |
| Neurogene Inc. | COM | $20.4M | 0.1%Prev: 0.1% | 991,691 SH | Increased |
| Nurix Therapeutics, Inc. | COM | $88.4M | 0.5%Prev: 0.3% | 4,658,556 SH | Increased+776,431 SH |
| Nuvalent, Inc. | COM | $14.5M | 0.1%Prev: 0.1% | 143,937 SH | Increased |
| Pharvaris N.V. | COM | $10.4M | 0.1%Prev: 0.1% | 375,000 SH | Increased |
| Praxis Precision Medicines, Inc. | COM | $332.0M | 1.9%Prev: 0.3% | 1,126,488 SH | Increased+437,000 SH |
| Prelude Therapeutics Inc. | COM | $29.4M | 0.2%Prev: 0.1% | 10,123,824 SH | Increased |
| Protara Therapeutics, Inc. | COM STK | $5.2M | 0.0%Prev: 0.0% | 971,614 SH | Increased+434,782 SH |
| Rapport Therapeutics, Inc. | COM | $46.9M | 0.3%Prev: 0.3% | 1,547,090 SH | Increased |
| Relay Therapeutics, Inc. | COM | $9.8M | 0.1%Prev: 0.0% | 1,160,117 SH | Increased |
| Replimune Group, Inc. | COM | $107.4M | 0.6%Prev: 0.3% | 11,045,336 SH | Increased |
| Revolution Medicines, Inc. | COM | $753.1M | 4.4%Prev: 3.2% | 9,455,357 SH | Increased |
| Rhythm Pharmaceuticals, Inc. | COM | $599.9M | 3.5%Prev: 4.1% | 5,604,483 SH | Increased |
| Roivant Sciences Ltd. | SHS | $120.5M | 0.7%Prev: 0.4% | 5,555,017 SH | Increased+1,787,244 SH |
| Sagimet Biosciences Inc. | COM SER A | $5.6M | 0.0%Prev: 0.0% | 952,996 SH | Decreased |
| Sana Biotechnology, Inc. | COM | $1.3M | 0.0%Prev: 0.1% | 310,483 SH | Decreased-1,720,466 SH |
| Sera Prognostics, Inc. | CLASS A COM | $16.2M | 0.1%Prev: 0.1% | 5,498,170 SH | Decreased |
| Sionna Therapeutics, Inc. | COM | $16.5M | 0.1%Prev: 0.1% | 400,000 SH | Increased |
| Skye Bioscience, Inc. | COM | $1.1M | 0.0%Prev: 0.0% | 1,450,638 SH | Decreased |
| Spyre Therapeutics, Inc. | COM | $32.8M | 0.2%Prev: 0.1% | 1,000,000 SH | Increased |
| Stoke Therapeutics, Inc. | COM | $105.9M | 0.6%Prev: 0.8% | 3,336,697 SH | Decreased-1,297,141 SH |
| Structure Therapeutics Inc. | SPONSORED ADS | $99.6M | 0.6%Prev: 0.3% | 1,432,529 SH | Increased-123,580 SH |
| Summit Therapeutics Inc. | COM | $636.5M | 3.7%Prev: 5.0% | 36,391,063 SH | Decreased+2,668,089 SH |
| Surrozen, Inc. | W EXP 8/11/2026 | $17K | 0.0%Prev: 0.0% | 833,333 SH | Increased |
| Taysha Gene Therapies, Inc. | COM SHS | $22.0M | 0.1%Prev: 0.1% | 4,004,756 SH | Increased |
| Tectonic Therapeutic, Inc. | COM | $18.8M | 0.1%Prev: 0.0% | 903,400 SH | Increased+803,400 SH |
| Terns Pharmaceuticals, Inc. | COM | $38.4M | 0.2% | 950,000 SH | New |
| TScan Therapeutics, Inc. | COM | $2.8M | 0.0%Prev: 0.0% | 2,784,792 SH | Decreased |
| Tyra Biosciences, Inc. | COM | $279K | 0.0%Prev: 0.0% | 10,607 SH | Increased |
| Ultragenyx Pharmaceutical Inc. | COM | $63.8M | 0.4%Prev: 0.6% | 2,772,692 SH | Decreased |
| Ventyx Biosciences, Inc. | COM | $21.2M | 0.1%Prev: 0.0% | 2,349,280 SH | Increased+1,326,150 SH |
| Vir Biotechnology, Inc. | COM | $3.3M | 0.0%Prev: 0.0% | 542,539 SH | Increased |
| Viridian Therapeutics, Inc. | COM | $61.4M | 0.4%Prev: 0.3% | 1,971,678 SH | Increased+227,272 SH |
| vTv Therapeutics, Inc. | CL A | $5.9M | 0.0%Prev: 0.0% | 148,314 SH | Increased |
| Wave Life Sciences Ltd. | SHS | $5.8M | 0.0%Prev: 0.0% | 344,063 SH | Increased |
| Xencor, Inc. | COM | $16.9M | 0.1%Prev: 0.1% | 1,102,106 SH | Increased |
| Xenon Pharmaceuticals Inc. | COM | $16.6M | 0.1%Prev: 0.1% | 370,208 SH | Increased |