| ABIVAX SA | SPONSORED ADS | $68.1M | 3.9%Prev: 2.7% | 505,000 SH | Increased+145,000 SH |
| ADAGIO MED HLDGS INC | COM | $83K | 0.0%Prev: 0.0% | 80,000 SH | Decreased |
| ALKERMES PLC | SHS | $28.0M | 1.6%Prev: 3.3% | 1,000,000 SH | Decreased-250,000 SH |
| AMGEN INC | COM | $47.5M | 2.7% | 145,000 SH | New |
| ANAPTYSBIO INC | COM | $21.6M | 1.2% | 444,692 SH | New |
| ANTERIS TECHNOLOGIES GLOBAL | COM | $2.4M | 0.1%Prev: 0.2% | 486,684 SH | Increased+36,684 SH |
| APOGEE THERAPEUTICS INC | COM | $93.2M | 5.3%Prev: 4.1% | 1,234,926 SH | Increased+61,500 SH |
| ARBUTUS BIOPHARMA CORP | COM | $2.5M | 0.1%Prev: 0.1% | 521,900 SH | Increased+310,400 SH |
| ARCELLX INC | COMMON STOCK | $34.1M | 1.9%Prev: 3.6% | 523,725 SH | Decreased+23,725 SH |
| ARCUS BIOSCIENCES INC | COM | $7.1M | 0.4% | 300,000 SH | New |
| ARRIVENT BIOPHARMA INC | COM | $3.0M | 0.2% | 150,000 SH | New |
| ARROWHEAD PHARMACEUTICALS IN | COM | $4.6M | 0.3% | 70,000 SH | New |
| ASCENDIS PHARMA A/S | SPONSORED ADR | $6.4M | 0.4% | 30,000 SH | New |
| AVADEL PHARMACEUTICALS PLC | COM SHS | $5.4M | 0.3% | 250,000 SH | New |
| AVALO THERAPEUTICS INC | COM NEW | $19.1M | 1.1%Prev: 1.1% | 1,051,054 SH | Increased+44,837 SH |
| BELITE BIO INC | SPONSORED ADS | $3.2M | 0.2% | 20,000 SH | New |
| BRIDGEBIO PHARMA INC | COM | $24.5M | 1.4%Prev: 0.3% | 320,000 SH | Increased+255,000 SH |
| CELCUITY INC | NOTE 2.750% 8/0 | $6.5M | 0.4%Prev: 0.3% | 3,000,000 PRN | Increased |
| CELLDEX THERAPEUTICS INC NEW | COM NEW | $9.5M | 0.5%Prev: 0.7% | 350,000 SH | Increased+50,000 SH |
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | $15.0M | 0.9%Prev: 2.3% | 600,552 SH | Decreased-506,610 SH |
| CLIMB BIO INC | COM | $5.2M | 0.3%Prev: 0.2% | 1,300,000 SH | Increased |
| COGENT BIOSCIENCES INC | COM | $12.4M | 0.7% | 350,000 SH | New |
| COGENT BIOSCIENCES INC | NOTE 1.625%11/1 | $1.2M | 0.1% | 1,000,000 PRN | New |
| COMPASS PATHWAYS PLC | SPONSORED ADS | $1.4M | 0.1%Prev: 0.1% | 200,000 SH | Increased |
| CRINETICS PHARMACEUTICALS IN | COM | $3.5M | 0.2%Prev: 0.3% | 75,000 SH | Increased |
| CULLINAN THERAPEUTICS INC | COM | $20.0M | 1.1%Prev: 0.1% | 1,932,106 SH | Increased+1,668,289 SH |
| CYTOKINETICS INC | COM NEW | $50.8M | 2.9%Prev: 1.7% | 800,000 SH | Increased+450,000 SH |
| DIANTHUS THERAPEUTICS INC | COM | $4.7M | 0.3%Prev: 0.9% | 115,000 SH | Decreased-147,100 SH |
| ENGENE HOLDINGS INC | COM | $5.8M | 0.3%Prev: 0.0% | 643,370 SH | Increased+566,370 SH |
| ERASCA INC | COM | $14.5M | 0.8%Prev: 0.8% | 3,900,000 SH | Increased-385,787 SH |
| ESTABLISHMENT LABS HLDGS INC | COM | $14.6M | 0.8%Prev: 1.1% | 200,000 SH | Increased-110,000 SH |
| EUPRAXIA PHARMACEUTICALS INC | COM | $2.3M | 0.1%Prev: 0.2% | 300,000 SH | Increased |
| FORTE BIOSCIENCES INC | COM NEW | $27.6M | 1.6% | 1,011,890 SH | New |
| GERON CORP | COM | $2.0M | 0.1%Prev: 0.2% | 1,500,000 SH | Decreased |
| IBIO INC | COM NEW | $4.0M | 0.2% | 2,057,200 SH | New |
| IMMUNOVANT INC | COM | $5.1M | 0.3%Prev: 0.4% | 200,000 SH | Increased-100,000 SH |
| INSMED INC | COM PAR $.01 | $78.3M | 4.5%Prev: 8.2% | 450,000 SH | Decreased-205,000 SH |
| ISHARES TR | ISHARES BIOTECH | $67.5M | 3.8% | 400,000 SH | New |
| JADE BIOSCIENCES INC | COM NEW | $11.0M | 0.6%Prev: 0.0% | 714,956 SH | Increased+649,639 SH |
| KARYOPHARM THERAPEUTICS INC | COM NEW | $6.5M | 0.4%Prev: 0.1% | 889,575 SH | Increased+731,975 SH |
| KEZAR LIFE SCIENCES INC | COM NEW | $1.4M | 0.1% | 229,076 SH | New |
| LENZ THERAPEUTICS INC | COM | $1.6M | 0.1% | 100,000 SH | New |
| LEXEO THERAPEUTICS INC | COM | $31.8M | 1.8%Prev: 2.2% | 3,200,000 SH | Increased-670,527 SH |
| MACROGENICS INC | COM | $780K | 0.0% | 484,308 SH | New |
| MADRIGAL PHARMACEUTICALS INC | COM | $18.1M | 1.0%Prev: 4.6% | 31,131 SH | Decreased-83,869 SH |
| MBX BIOSCIENCES INC | COM | $7.9M | 0.4%Prev: 0.3% | 250,000 SH | Increased+85,000 SH |
| MERSANA THERAPEUTICS INC | COM | $2.9M | 0.2% | 100,000 SH | New |
| MINERALYS THERAPEUTICS INC | COM | $26.5M | 1.5%Prev: 2.5% | 730,000 SH | Decreased-20,000 SH |
| NEWAMSTERDAM PHARMA COMPANY | *W EXP 99/99/999 | $5.6M | 0.3%Prev: 0.4% | 245,000 SH | Increased |
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | $9.6M | 0.5%Prev: 0.7% | 275,000 SH | Increased |
| NEXTCURE INC | COM NEW | $3.5M | 0.2%Prev: 0.1% | 247,294 SH | Increased+55,412 SH |
| NURIX THERAPEUTICS INC | COM | $18.4M | 1.0%Prev: 0.8% | 967,620 SH | Increased |
| NUVALENT INC | COM | $32.5M | 1.8%Prev: 2.9% | 322,633 SH | Decreased-61,784 SH |
| OAKTREE ACQUISITION CORP III | UNIT 10/04/2029 | $2.7M | 0.2%Prev: 0.2% | 250,000 SH | Decreased |
| OMEROS CORP | NOTE 9.500% 6/1 | $19.4M | 1.1%Prev: 0.4% | 6,525,000 PRN | Increased+1,000,000 PRN |
| ORCHESTRA BIOMED HLDGS INC | COM | $2.4M | 0.1%Prev: 0.2% | 572,804 SH | Increased-154,468 SH |
| ORUKA THERAPEUTICS INC | COM | $24.3M | 1.4%Prev: 1.6% | 802,342 SH | Increased-156,838 SH |
| OVID THERAPEUTICS INC | COM | $11.7M | 0.7%Prev: 0.3% | 7,150,000 SH | Increased+4,500,000 SH |
| PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | $652K | 0.0%Prev: 0.3% | 50,000 SH | Decreased-300,000 SH |
| PERSPECTIVE THERAPEUTICS INC | COM NEW | $825K | 0.0%Prev: 0.1% | 300,000 SH | Decreased |
| PRAXIS PRECISION MEDICINES I | COM NEW | $54.5M | 3.1% | 185,000 SH | New |
| PROQR THRAPEUTICS N V | SHS EURO | $5.0M | 0.3%Prev: 0.7% | 2,454,278 SH | Decreased-1,145,722 SH |
| PROTAGONIST THERAPEUTICS INC | COM | $15.0M | 0.9%Prev: 1.3% | 172,125 SH | Increased-48,475 SH |
| Q32 BIO INC | COM | $92K | 0.0%Prev: 0.0% | 27,777 SH | Increased |
| REVOLUTION MEDICINES INC | COM | $8.0M | 0.5%Prev: 0.4% | 100,000 SH | Increased |
| REZOLUTE INC | COM NEW | $5.5M | 0.3%Prev: 1.7% | 2,351,144 SH | Decreased+251,144 SH |
| ROCKET PHARMACEUTICALS INC | *W EXP 09/02/202 | $2K | 0.0%Prev: 0.0% | 75,000 SH | Decreased |
| ROIVANT SCIENCES LTD | SHS | $36.9M | 2.1%Prev: 1.1% | 1,700,000 SH | Increased+900,000 SH |
| SAGIMET BIOSCIENCES INC | COM SER A | $6.8M | 0.4%Prev: 0.2% | 1,148,245 SH | Increased+798,245 SH |
| SAVARA INC | COM | $16.9M | 1.0%Prev: 0.5% | 2,797,153 SH | Increased+1,297,153 SH |
| SELECT SECTOR SPDR TR | STATE STREET HEA | $38.7M | 2.2% | 250,000 SH | New |
| SPDR SERIES TRUST | STATE STREET SPD | $182.9M | 10.4% | 1,500,000 SH | New |
| SPYRE THERAPEUTICS INC | COM NEW | $46.9M | 2.7%Prev: 2.1% | 1,432,591 SH | Increased+13,292 SH |
| SUMMIT THERAPEUTICS INC | COM | $6.1M | 0.3%Prev: 0.6% | 350,000 SH | Decreased |
| SUTRO BIOPHARMA INC | COM SHS | $8.7M | 0.5% | 748,382 SH | New |
| TANGO THERAPEUTICS INC | COM | $8.9M | 0.5% | 1,000,000 SH | New |
| TAYSHA GENE THERAPIES INC | COM SHS | $18.1M | 1.0%Prev: 0.9% | 3,300,000 SH | Increased+300,000 SH |
| TERNS PHARMACEUTICALS INC | COM | $22.2M | 1.3% | 550,000 SH | New |
| TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | $43.7M | 2.5%Prev: 2.5% | 1,400,000 SH | Increased |
| TRAVERE THERAPEUTICS INC | COM | $11.5M | 0.7%Prev: 1.0% | 300,000 SH | Decreased-200,000 SH |
| TRAVERE THERAPEUTICS INC | NOTE 2.250% 3/0 | $10.0M | 0.6%Prev: 0.7% | 7,000,000 PRN | Increased |
| TREVI THERAPEUTICS INC | COM | $26.9M | 1.5%Prev: 2.2% | 2,150,172 SH | Increased-649,828 SH |
| ULTRAGENYX PHARMACEUTICAL IN | COM | $1.7M | 0.1% | 75,000 SH | New |
| UNIQURE NV | SHS | $20.3M | 1.2%Prev: 1.5% | 850,000 SH | Increased+550,000 SH |
| VENTYX BIOSCIENCES INC | COM | $58.6M | 3.3%Prev: 1.1% | 6,484,558 SH | Increased+2,560,143 SH |
| VERA THERAPEUTICS INC | CL A | $12.7M | 0.7%Prev: 0.8% | 250,000 SH | Increased-53,330 SH |
| VERRICA PHARMACEUTICALS INC | COM SHS | $5.9M | 0.3% | 707,338 SH | New |
| VIRIDIAN THERAPEUTICS INC | COM | $7.8M | 0.4%Prev: 0.5% | 250,000 SH | Increased |
| WAVE LIFE SCIENCES LTD | SHS | $45.9M | 2.6%Prev: 1.3% | 2,700,000 SH | Increased+600,000 SH |
| X4 PHARMACEUTICALS INC | COM NEW | $580K | 0.0% | 145,000 SH | New |
| XENON PHARMACEUTICALS INC | COM | $56.0M | 3.2%Prev: 4.9% | 1,250,000 SH | Decreased-150,000 SH |
| ZURA BIO LTD | CLASS A ORD SHS | $9.5M | 0.5%Prev: 0.5% | 1,813,671 SH | Increased+539,320 SH |