X0609 4 2026-09-24 0001628171 Revolution Medicines, Inc. RVMD 0002124509 Mancini Anthony false REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 false true false false See Remarks true Common Stock 2026-09-24 4 S false 587 200 D 39765 D Common Stock 2026-09-25 4 M false 3121 33.62 A 42886 D Common Stock 2026-09-25 4 S false 3121 200.54 D 39765 D Stock Option (Right to Buy) 33.62 2026-09-25 4 M false 3121 0 D 2035-03-31 Common Stock 3121 93625 D Transaction made pursuant to a 10b5-1 trading plan adopted by Anthony Mancini on June 11, 2026. Includes 39,575 restricted stock units. Twenty-five percent of the total shares subject to the option will vest on the first year anniversary measured from April 1, 2025 (the "Vesting Commencement Date") and one forty-eighth (1/48th) of the shares subject to the option will vest on each monthly anniversary of the Vesting Commencement Date thereafter, so that 100% of the shares subject to the option will be fully vested and exercisable as of the fourth anniversary of the Vesting Commencement Date, subject to the Reporting Person's continued service through each vesting date. Chief Global Commercialization Officer /s/ Jack Anders, as Attorney-in-fact for Anthony Mancini 2026-09-28