X0508 4 2025-12-24 0001806952 Lyell Immunopharma, Inc. LYEL 0002095702 Bulis Veronica Sanchez C/O LYELL IMMUNOPHARMA, INC. 201 HASKINS WAY, SUITE 101 SOUTH SAN FRANCISCO CA 94080 false true false false VP, Corporate Controller 0 Common Stock 2025-12-24 4 S 0 1136 38.67 D 8077 D Common Stock 2025-12-30 4 S 0 936 32.32 D 7141 D The price reported above reflects the weighted average price of the shares sold. The sale price ranged from $38.6643 to $38.6751 per share. Upon request from the SEC staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. /s/ Mark Meltz, Attorney-in-Fact 2026-01-06