X0508 4 2025-12-11 0 0002019410 Caris Life Sciences, Inc. CAI 0002072013 Power Luke Thomas C/O CARIS LIFE SCIENCES, INC. 750 W. JOHN CARPENTER FREEWAY, SUITE 800 IRVING TX 75039 0 1 0 0 See Remarks 1 Common Stock 2025-12-11 4 M 0 24750 2.44 A 124321 D Common Stock 2025-12-11 4 M 0 37500 2.44 A 161821 D Common Stock 2025-12-11 4 S 0 60850 26.5644 D 100971 D Common Stock 2025-12-11 4 S 0 1400 27.1554 D 99571 D Stock Option 2.44 2025-12-11 4 M 0 24750 0 D 2027-05-30 Common Stock 24750 0 D Stock Option 2.44 2025-12-11 4 M 0 37500 0 D 2028-11-14 Common Stock 37500 0 D The option exercises and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 19, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.11 to $27.07, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $27.11 to $27.20, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The stock option is fully vested and exercisable. Senior Vice President, Chief Financial Officer, and Chief Accounting Officer /s/ J. Russel Denton, Attorney-in-Fact 2025-12-12