X0609 4 2026-09-17 0 0002019410 Caris Life Sciences, Inc. CAI 0002071959 Brille Brian J false C/O CARIS LIFE SCIENCES, INC. 750 W. JOHN CARPENTER FREEWAY, SUITE 800 IRVING TX 75039 1 1 0 0 See Remarks 0 Common Stock 2026-09-17 4 M 0 400000 2.44 A 630303 D Common Stock 2026-09-17 4 S 0 400000 30.3302 D 230303 D Common Stock 500000 I By Trust Stock Option 2.44 2026-09-17 4 M 0 400000 0 D 2028-01-14 Common Stock 400000 1600000 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $30.2100 to $30.5650, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The Reporting Person disclaims beneficial ownership except to the extent of his pecuniary interest therein. By a family trust, with shares previously held in multiple family trusts consolidated into a single trust. The stock option is fully vested and exercisable. Vice Chairman and Executive Vice President /s/ J. Russel Denton, Attorney-in-Fact 2026-09-17