X0609 4 2026-09-03 0 0002019410 Caris Life Sciences, Inc. CAI 0002071953 Spetzler David Baxley false C/O CARIS LIFE SCIENCES, INC. 750 W. JOHN CARPENTER FREEWAY, SUITE 800 IRVING TX 75039 0 1 0 0 President 0 Common Stock 2026-09-03 4 M 0 1000000 2.44 A 1530083 D Common Stock 2026-09-03 4 S 0 393100 24.7604 D 1136983 D Common Stock 2026-09-03 4 S 0 84900 25.3201 D 1052083 D Common Stock 2026-09-04 4 M 0 250000 2.44 A 1302083 D Common Stock 2026-09-04 4 S 0 119212 24.7552 D 1182871 D Stock Option 2.44 2026-09-03 4 M 0 1000000 0 D 2026-09-12 Common Stock 1000000 250000 D Stock Option 2.44 2026-09-04 4 M 0 250000 0 D 2026-09-12 Common Stock 250000 0 D The sales reported on this Form 4 were effected pursuant to a broker-assisted sell-to-cover exercise of fully vested stock options scheduled to expire on September 12, 2026. The shares were sold solely to cover the aggregate exercise price and applicable tax withholding obligations. The Reporting Person retained all remaining shares acquired upon exercise. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $24.3200 to $25.3100, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.3200 to $25.3300, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $24.5550 to $25.1200, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Exercise of stock options before their expiration date. The stock option is fully vested and exercisable. President /s/ J. Russel Denton, Attorney-in-Fact 2026-09-04