X0609 4 2026-09-22 0 0002019410 Caris Life Sciences, Inc. CAI 0002071923 Denton John Russel false C/O CARIS LIFE SCIENCES, INC. 750 W. JOHN CARPENTER FREEWAY, SUITE 800 IRVING TX 75039 0 1 0 0 See Remarks 0 Common Stock 2026-09-22 4 S 0 7500 31.8168 D 174855 D Common Stock 9184 I By Trust The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $31.7750 to $31.8700, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Includes shares acquired in a non-reportable transaction under the Caris Life Sciences, Inc. 2025 Employee Stock Purchase Plan (a tax-qualified plan) after the date of the reporting person's previous Form 4. Senior Vice President, General Counsel, and Secretary /s/ J. Russel Denton 2026-09-23