X0508 4 2025-11-07 0 0002019410 Caris Life Sciences, Inc. CAI 0002071923 Denton John Russel C/O CARIS LIFE SCIENCES, INC. 750 W. JOHN CARPENTER FREEWAY, SUITE 800 IRVING TX 75039 0 1 0 0 See Remarks 0 Common Stock 2025-11-07 4 P 0 4184 24.09 A 9184 I By Trust Common Stock 123591 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $23.99 to $24.15, inclusive. The reporting person undertakes to provide to Caris Life Sciences, Inc., any security holder of Caris Life Sciences, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. Senior Vice President, General Counsel, and Secretary /s/ J. Russel Denton 2025-11-10