X0508 4 2025-12-16 0001346830 Tvardi Therapeutics, Inc. TVRD 0002064889 O'Brien Stephen Paul C/O TVARDI THERAPEUTICS, INC. 3 SUGAR CREEK CTR BLVD, STE 525 SUGAR LAND TX 77478 false true false false Principal Accounting Officer 0 Employee Stock Option (right to buy) 4.20 2025-12-16 4 A 0 4000 0 A 2035-12-16 Common Stock 4000 4000 D 25% of the shares subject to the option shall vest on December 16, 2026, and the balance of the shares subject to the option shall vest in equal monthly installments over the following 36 months, subject to the Reporting Person's continuous service through each applicable vesting date. /s/ Dan Conn, Attorney-in-Fact 2025-12-18