X0508 4 2025-12-01 0001177648 ENANTA PHARMACEUTICALS INC ENTA 0002085123 Trout Harry R. III C/O ENANTA PHARMACEUTICALS, INC. 4 KINGSBURY AVENUE WATERTOWN MA 02472 0 1 0 0 See Remarks 0 Common Stock 2025-12-01 4 F 0 105 14.12 D 17270 D Common Stock 2025-12-02 4 S 0 380 13.96 D 16890 D Represents the number of shares of ENTA common stock forfeited by the reporting person to cover withholding taxes due as a result of settlement of a portion of the restricted stock unit award granted on November 19, 2021. Represents shares sold by the reporting person to cover withholding taxes due as a result of settlement of a portion of the restricted stock unit award granted on November 27, 2024, as required pursuant to the terms of the award. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the reporting person. Vice President, Finance (Principal Financial Officer) /s/ Matthew Kowalsky as attorney-in-fact 2025-12-03