X0508 4 2026-01-30 0 0001867096 Xeris Biopharma Holdings, Inc. XERS 0002058704 Nguyen Anh Tu C/O XERIS BIOPHARMA HOLDINGS, INC. 1375 WEST FULTON STREET, SUITE 1300 CHICAGO IL 60607 0 1 0 0 See Remarks 0 Common Stock 2026-01-30 4 A 0 121293 0 A 424323 D Common Stock 3710 I By IRA Common Stock 3501 I By children's IRA Stock Option (Right to Buy) 7.36 2026-01-30 4 A 0 162162 0 A 2036-01-30 Common Stock 162162 162162 D These shares were acquired pursuant to a restricted stock unit grant under the Company's 2018 Stock Option and Incentive Plan (the "Plan"). Each restricted stock unit represents a contingent right to receive one share of the Company's common stock. These shares shall vest in equal annual installments over three years, subject to continued employment through such vesting date. Includes 3,030 shares acquired on December 31, 2025 under the issuer's 2018 Employee Stock Purchase Plan, as amended. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. These stock options were acquired pursuant to a grant under the Plan. These stock options shall vest in equal annual installments over three years, subject to continued service through such vesting date. Chief Medical Officer /s/ Beth Hecht, Attorney-in-Fact 2026-02-02