X0508 4 2026-02-04 0001818331 GeneDx Holdings Corp. WGS 0002051759 Dechairo Bryan C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST., NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 false true false false Chief Operating Officer 1 Class A Common Stock 2026-02-04 4 S 0 779 83.0352 D 5182 D Class A Common Stock 2026-02-04 4 S 0 1425 83.8287 D 3757 D Class A Common Stock 2026-02-04 4 S 0 1034 84.9280 D 2723 D Class A Common Stock 2026-02-04 4 S 0 623 86.3498 D 2100 D Class A Common Stock 2026-02-04 4 S 0 1572 87.6613 D 528 D Class A Common Stock 2026-02-04 4 S 0 328 88.6632 D 200 D Class A Common Stock 2026-02-04 4 S 0 100 90.4540 D 100 D Class A Common Stock 2026-02-04 4 S 0 100 91.9200 D 0 D This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 15, 2025. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.33 to $83.31 per share, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnotes 3 through 8 of this Form 4. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $83.33 to $84.32 per share, inclusive. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $84.50 to $85.41 per share, inclusive. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $85.77 to $86.70 per share, inclusive. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $87.30 to $88.26 per share, inclusive. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $88.34 to $88.80 per share, inclusive. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $90.44 to $90.51 per share, inclusive. Following the reported transactions, which were undertaken pursuant to the reporting person's 10b5-1 trading plan, the reporting person beneficially owned RSUs representing contingent rights to receive up to an aggregate 28,123 shares of Class A Common Stock, which RSUs vest according to their terms. /s/ Bridget Brown, Attorney-in-Fact 2026-02-06