X0508 4 2026-02-01 0001818331 GeneDx Holdings Corp. WGS 0002051759 Dechairo Bryan C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST., NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 false true false false Chief Operating Officer 0 Class A Common Stock 2026-02-01 4 M 0 9374 0 A 9374 D Class A Common Stock 2026-02-02 4 S 0 93 96.7676 D 9281 D Class A Common Stock 2026-02-02 4 S 0 492 98.6117 D 8789 D Class A Common Stock 2026-02-02 4 S 0 1662 99.3974 D 7127 D Class A Common Stock 2026-02-02 4 S 0 1166 100.3146 D 5961 D Restricted Stock Unit 2026-02-01 4 M 0 9374 0 D Class A Common Stock 9374 28123 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.60 to $96.86, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and in footnotes 4 through 6 of this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.895 to $98.88, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $98.9075 to $99.88, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.93 to $100.7675, inclusive. Following the reported sale undertaken to satisfy tax withholding liabilities, in addition to the 5,961 shares of Class A Common Stock beneficially owned by the Reporting Person, the Reporting Person beneficially owned RSUs representing contingent rights to receive up to an aggregate 28,123 shares of Class A Common Stock, which RSUs vest according to their terms. 1/4 of the total award vested or vests annually, subject to the Reporting Person's continued service to the Issuer on each vesting date, and with the first tranche vested on February 1, 2026. These RSUs do not have an expiration date; they either vest or are cancelled prior to the vesting date. /s/ Bridget Brown, Attorney-in-Fact 2026-02-03