X0508 4 2025-11-21 0 0002023658 Bicara Therapeutics Inc. BCAX 0002034668 Hyep Ivan BICARA THERAPEUTICS INC. 116 HUNTINGTON AVENUE, SUITE 703 BOSTON MA 02116 0 1 0 0 Chief Financial Officer 1 Common Stock 2025-11-21 4 M 0 605 3.7898 A 145960 D Common Stock 2025-11-21 4 S 0 605 18.15 D 145355 D Common Stock 2025-11-24 4 M 0 17795 3.7898 A 163150 D Common Stock 2025-11-24 4 S 0 17795 18.5498 D 145355 D Stock Option (Right to Buy) 3.7898 2025-11-21 4 M 0 605 0 D 2033-08-08 Common Stock 605 115979 D Stock Option (Right to Buy) 3.7898 2025-11-24 4 M 0 17795 0 D 2033-08-08 Common Stock 17795 98184 D This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on February 13, 2025. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $18.15 to $18.84, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The shares underlying this option vest in sixteen equal quarterly installments following August 8, 2023, subject to the Reporting Person's continued service on each such vesting date. /s/ Lara Meisner, Attorney-in-Fact 2025-11-25