X0609 4 2026-09-01 0001717115 Tempus AI, Inc. TEM 0002024250 Fukushima Ryan false C/O TEMPUS AI, INC. 600 WEST CHICAGO AVENUE, SUITE 510 CHICAGO IL 60654 false true false false CEO, Data 1 Class A Common Stock 2026-09-01 4 S 0 13046 62.12 D 34374 I By Spouse Class A Common Stock 2026-09-01 4 S 0 10900 62.64 D 23474 I By Spouse Class A Common Stock 2026-09-01 4 S 0 5900 63.80 D 17574 I By Spouse Class A Common Stock 2026-09-01 4 S 0 1000 64.63 D 16574 I By Spouse Class A Common Stock 562463 D This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse on March 12, 2026. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $61.33 to $62.32 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $62.33 to $63.32 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $63.33 to $64.31 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.34 to $65.00 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Andrew Polovin, Attorney-in-Fact 2026-09-03