X0508 4 2025-12-09 0 0001232524 Jazz Pharmaceuticals plc JAZZ 0001989533 Henderson Mary Elizabeth 5TH FL, WATERLOO EXCHANGE WATERLOO RD DUBLIN 4 L2 IRELAND 0 1 0 0 SVP, Technical Operations 0 Ordinary Shares 2025-12-09 4 S 0 2238 169.511 D 19508 D Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $169.00 to $169.82. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. By: /s/Paz Dizon, as attorney in fact For: Mary Elizabeth Henderson 2025-12-11