X0508 4 2025-12-10 0 0001651308 BeOne Medicines Ltd. ONC 0001980648 Lee Chan Henry C/O BEONE MEDICINES I GMBH AESCHENGRABEN 27, 21ST FLOOR BASEL V8 4051 SWITZERLAND 0 1 0 0 SVP, General Counsel 1 Ordinary Shares 223106 D American Depositary Shares 2025-12-10 4 M 0 101 194.47 A 101 D American Depositary Shares 2025-12-10 4 M 0 133 213.32 A 234 D American Depositary Shares 2025-12-10 4 M 0 98 159.03 A 332 D American Depositary Shares 2025-12-10 4 S 0 332 318.28 D 0 D American Depositary Shares 2025-12-11 4 M 0 101 194.47 A 101 D American Depositary Shares 2025-12-11 4 M 0 133 213.32 A 234 D American Depositary Shares 2025-12-11 4 M 0 98 159.03 A 332 D American Depositary Shares 2025-12-11 4 S 0 332 325 D 0 D Share Option (Right to Buy) 14.96 2025-12-10 4 M 0 1313 0 D 2032-08-04 Ordinary Shares 1313 34385 D Share Option (Right to Buy) 16.41 2025-12-10 4 M 0 1729 0 D 2033-06-14 Ordinary Shares 1729 102206 D Share Option (Right to Buy) 12.23 2025-12-10 4 M 0 1274 0 D 2034-06-04 Ordinary Shares 1274 121940 D Share Option (Right to Buy) 14.96 2025-12-11 4 M 0 1313 0 D 2032-08-04 Ordinary Shares 1313 33072 D Share Option (Right to Buy) 16.41 2025-12-11 4 M 0 1729 0 D 2033-06-14 Ordinary Shares 1729 100477 D Share Option (Right to Buy) 12.23 2025-12-11 4 M 0 1274 0 D 2034-06-04 Ordinary Shares 1274 120666 D Each American Depositary Share represents 13 Ordinary Shares. The sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2025. The number of securities underlying each option and the exercise price therefore are represented in ordinary shares. These securities vest over a four-year period as follows: 25% on July 29, 2023 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events. These securities vest over a four-year period as follows: 25% on the first anniversary of June 15, 2023 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events. These securities vest over a four-year period as follows: 25% on the first anniversary of June 5, 2024 with the remaining shares vesting in 36 equal successive monthly installments thereafter, subject to continued service. Unvested securities are subject to accelerated vesting upon certain termination events. /s/ Qing Nian, as Attorney-in-Fact 2025-12-12