X0508 4 2026-01-14 0001727196 Scholar Rock Holding Corp SRRK 0001980298 Qatanani Mo 301 BINNEY STREET CAMBRIDGE MA 02142 false true false false CHIEF SCIENTIFIC OFFICER 1 Common Stock 2026-01-14 4 M 0 1407 18.08 A 110371 D Common Stock 2026-01-14 4 M 0 321 7.62 A 110692 D Common Stock 2026-01-14 4 M 0 2813 10 A 113505 D Common Stock 2026-01-14 4 M 0 5893 15.75 A 119398 D Common Stock 2026-01-14 4 M 0 2678 35.15 A 122076 D Common Stock 2026-01-14 4 S 0 13112 45.1961 D 108964 D Stock Option (Right to Buy) 18.08 2026-01-14 4 M 0 1407 0 D 2032-02-14 Common Stock 1407 0 D Stock Option (Right to Buy) 7.62 2026-01-14 4 M 0 321 0 D 2032-10-10 Common Stock 321 961 D Stock Option (Right to Buy) 10 2026-01-14 4 M 0 2813 0 D 2033-02-13 Common Stock 2813 11250 D Stock Option (Right to Buy) 15.75 2026-01-14 4 M 0 5893 0 D 2034-02-12 Common Stock 5893 47143 D Stock Option (Right to Buy) 35.15 2026-01-14 4 M 0 2678 0 D 2035-03-10 Common Stock 2678 32142 D This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025. Consists of 1,407 shares of common stock and 108,964 RSUs. Consists of 1,728 shares of common stock and 108,964 RSUs. Consists of 4,541 shares of common stock and 108,964 RSUs. Consists of 10,434 shares of common stock and 108,964 RSUs. Consists of 13,112 shares of common stock and 108,964 RSUs. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.00 to $45.45, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. Consists of 108,964 RSUs. No shares remain unvested under this stock option. 961 shares remain unvested under this stock option. The first vesting event occurred on January 5, 2023 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date. 11,250 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2023 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date. 47,143 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2024 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date. 32,142 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2025 and the remainder vests in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date. /s/ Junlin Ho, Attorney-in-Fact for Mo Qatanani 2026-01-16