X0508 4 2025-12-04 0001727196 Scholar Rock Holding Corp SRRK 0001980298 Qatanani Mo 301 BINNEY STREET CAMBRIDGE MA 02142 false true false false CHIEF SCIENTIFIC OFFICER 1 Common Stock 2025-12-04 4 M 0 65625 26.05 A 174589 D Common Stock 2025-12-04 4 M 0 21093 18.08 A 195682 D Common Stock 2025-12-04 4 M 0 5607 4.86 A 201289 D Common Stock 2025-12-04 4 M 0 1281 7.62 A 202570 D Common Stock 2025-12-04 4 M 0 11250 10 A 213820 D Common Stock 2025-12-04 4 M 0 23571 15.75 A 237391 D Common Stock 2025-12-04 4 M 0 8035 35.15 A 245426 D Common Stock 2025-12-04 4 S 0 136462 45.2125 D 108964 D Stock Option (Right to Buy) 26.05 2025-12-04 4 M 0 65625 0 D 2031-10-26 Common Stock 65625 4375 D Stock Option (Right to Buy) 18.08 2025-12-04 4 M 0 21093 0 D 2032-02-14 Common Stock 21093 1407 D Stock Option (Right to Buy) 4.86 2025-12-04 4 M 0 5607 0 D 2032-06-16 Common Stock 5607 0 D Stock Option (Right to Buy) 7.62 2025-12-04 4 M 0 1281 0 D 2032-10-10 Common Stock 1281 1282 D Stock Option (Right to Buy) 10 2025-12-04 4 M 0 11250 0 D 2033-02-13 Common Stock 11250 14063 D Stock Option (Right to Buy) 15.75 2025-12-04 4 M 0 23571 0 D 2034-12-12 Common Stock 23571 53036 D Stock Option (Right to Buy) 35.15 2025-12-04 4 M 0 8035 0 D 2035-03-10 Common Stock 8035 34820 D This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025. Consists of 65,625 shares of common stock and 108,964 RSUs. Consists of 86,718 shares of common stock and 108,964 RSUs. Consists of 92,325 shares of common stock and 108,964 RSUs Consists of 93,606 shares of common stock and 108,964 RSUs. Consists of 104,856 shares of common stock and 108,964 RSUs. Consists of 128,427 shares of common stock and 108,964 RSUs. Consists of 136,462 shares of common stock and 108,964 RSUs. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $45.00 to $45.46, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request. Consists of 108,964 RSUs. 1,282 shares remain unvested under this stock option. The first vesting event occurred on January 5, 2023 and the remainder vest in fifteen quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date. 1,407 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2022 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date. 14,063 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2023 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date. 53,036 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2024 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date. 34,820 shares remain unvested under this stock option. The first vesting event occurred on April 1, 2025 and the remainder vests in fifteen quarterly installments thereafter; provided the Reporting Person continues to have a service relationship with the Issuer on such vesting date. /s/ Junlin Ho, Attorney-in-Fact for Mo Qatanani 2025-12-05