X0508 4 2025-12-15 0 0001576280 Guardant Health, Inc. GH 0001977179 Chudova Darya 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief Technology Officer 0 Common Stock 2025-12-15 4 S 0 5451 104.0418 D 7012 D Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $104.0401 to $104.0900. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ John G. Saia, as attorney-in-fact for Darya Chudova 2025-12-17