X0508 4 2025-12-08 0 0001576280 Guardant Health, Inc. GH 0001977179 Chudova Darya 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief Technology Officer 0 Common Stock 2025-12-08 5 J 0 E 68144 0 D 21734 D Common Stock 2025-12-08 5 J 0 E 68144 0 A 68144 I Chudova Family Trust Common Stock 2025-12-08 4 S 0 9271 106.0029 D 12463 D Common Stock 2025-12-08 4 S 0 13664 105.0371 D 54480 I Chudova Family Trust Reflects changes in form of ownership from direct to indirect due to transfer of shares to The Chudova Family Trust. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.00 to $106.11. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $105.00 to $105.24. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Table I includes 488 shares acquired under the Guardant Health's Employee Stock Purchase Plan on 5/14/2023. /s/ John G. Saia, as attorney-in-fact for Darya Chudova 2025-12-10