X0508 4 2026-01-20 0001672619 Enliven Therapeutics, Inc. ELVN 0001967150 Lyssikatos Joseph P C/O ENLIVEN THERAPEUTICS, INC. 6200 LOOKOUT ROAD BOULDER CO 80301 false true false false CHIEF SCIENTIFIC OFFICER 1 Common Stock 2026-01-20 4 S 0 5491 26.373 D 759697 I See footnote Common Stock 2026-01-20 4 S 0 14509 26.8995 D 745188 I See footnote The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 15, 2024. This transaction was executed in multiple trades at prices ranging from $25.605 to $26.5928. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. The shares are held by The Lyssikatos Revocable Trust 12/15/2011 for which the Reporting Person serves as trustee. This transaction was executed in multiple trades at prices ranging from $26.6137 to $27.344. The price reported above reflects the weighted average sale price. The Reporting Person undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate sale price. /s/ Ben Hohl, by power of attorney 2026-01-22