X0508 4 2026-01-02 0 0001599298 Summit Therapeutics Inc. SMMT 0001963544 Xia Yu C/O SUMMIT THERAPEUTICS INC. 601 BRICKELL KEY DRIVE, SUITE 1000 MIAMI FL 33131 1 0 0 0 0 Stock Option (right to buy) 17.52 2026-01-02 4 A 0 35000 A 2036-01-02 Common Stock 35000 35000 D The option was granted on January 2, 2026. The shares underlying the option shall vest in four quarterly installments on March 31, June 30, September 30 and December 31 of the year of grant, subject to the reporting person remaining as a non-salaried director on each such vesting date. Not applicable. /s/ Adam Finerman, as Attorney-in-Fact for Yu Xia 2026-01-06