X0609 4 2026-08-18 0001888886 Structure Therapeutics Inc. GPCR 0001962926 Lin Xichen false C/O STRUCTURE THERAPEUTICS INC. 601 GATEWAY BLVD., SUITE 900 SOUTH SAN FRANCISCO CA 94080 false true false false CHIEF SCIENTIFIC OFFICER 1 Ordinary Shares 2026-08-18 4 M 0 11817 0.34 A 240777 D Ordinary Shares 2026-08-18 4 C 0 11817 0 D 228960 D Share Option (right to buy) 0.34 2026-08-18 4 M 0 11817 0 D 2029-09-10 Ordinary Shares 11817 142898 D American Depositary Shares 2026-08-18 4 C 0 3939 0 A Ordinary Shares 11817 3939 D American Depositary Shares 2026-08-18 4 S 0 3020 53.133 D Ordinary Shares 9060 919 D American Depositary Shares 2026-08-18 4 S 0 519 54.1970 D Ordinary Shares 1557 400 D American Depositary Shares 2026-08-18 4 S 0 400 55.05 D Ordinary Shares 1200 0 D Reflects price per share in Ordinary Shares. The Ordinary Shares were converted into American Depositary Shares as reported in Table II. 1/4 of the Ordinary Shares vested one year after July 22, 2019 (the "Vesting Commencement Date"); the balance of the Ordinary Shares vested in a series of 36 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date. This reflects the number of Ordinary Shares remaining under the share option following the partial exercise of the share option for 11,817 Ordinary Shares. Each American Depositary Share is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The American Depositary Shares have no expiration date. 11,817 Ordinary Shares, which were acquired upon exercise of a share option, were converted into 3,939 American Depositary Shares. The American Depositary Shares were sold pursuant to a Rule 10b5-1 trading plan entered into on March 26, 2026. Reflects price per share in American Depositary Shares. The weighted average sale price for the transaction reported was $53.133 and the range of prices were between $52.77 and $53.70. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of American Depositary Shares sold at each price will be provided. The weighted average sale price for the transaction reported was $54.1970, and the range of prices were between $53.80 and $54.7950. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of American Depositary Shares sold at each price will be provided. The weighted average sale price for the transaction reported was $55.05 and the range of prices were between $54.85 and $55.15. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of American Depositary Shares sold at each price will be provided. /s/ Jun Yoon, Attorney-in-Fact 2026-08-19