X0508 4 2025-12-23 0 0001649094 Vaxcyte, Inc. PCVX 0001960048 Cowan Elvia C/O VAXCYTE, INC. 825 INDUSTRIAL ROAD, SUITE 300 SAN CARLOS CA 94070 0 1 0 0 SVP, FINANCE 0 Common Stock 2025-12-23 4 S 0 4907 47.899 D 21250 D Common Stock 2025-12-23 4 S 0 6716 47.935 D 14534 D Common Stock 2025-12-23 4 G 0 1000 0 D 13534 D Includes one (1) share acquired on November 17, 2025 under the Issuer's Employee Stock Purchase Plan. Reflects the bona-fide gift of the Issuer's common stock to a Charitable Donor Advised Fund. Elvia Cowan, by /s/ Peter N. Efremenko, Attorney-In-Fact 2025-12-29