X0609 4 2026-09-01 0001818331 GeneDx Holdings Corp. WGS 0001944119 Feeley Kevin false C/O GENEDX HOLDINGS CORP. 333 LUDLOW ST., NORTH TOWER, 6TH FLOOR STAMFORD CT 06902 false true false false CHIEF FINANCIAL OFFICER 0 Class A Common Stock 2026-09-01 4 M 0 717 0 A 40671 D Class A Common Stock 2026-09-01 4 S 0 372 83.8390 D 40299 D Restricted Stock Unit 2026-09-01 4 M 0 717 0 D Class A Common Stock 717 0 D Each restricted stock unit ("RSU") represents a contingent right to receive 1 share of the Issuer's Class A Common Stock upon settlement for no consideration. The sale reported on this Form 4 represents shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The sale was to satisfy tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary transaction by the Reporting Person. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $83.71 to $83.84 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Following the reported sale undertaken to satisfy tax withholding liabilities, in addition to the 40,299 shares of Class A Common Stock beneficially owned by the Reporting Person, the Reporting Person held RSUs representing contingent rights to receive up to an aggregate 81,326 shares of the Issuer's Class A Common Stock and options to purchase up to an aggregate 25,906 shares of Class A Common Stock, which RSUs and options vest according to their respective terms. 6.25% of the total award vested or vests quarterly, with the first tranche vested on December 1, 2022, subject to the Reporting Person's continued service to the Issuer on each vesting date. These RSUs do not have an expiration date; they either vest or are cancelled prior to the vesting date. /s/ Bridget Brown, Attorney-in-Fact 2026-09-03