X0609 4 2026-07-13 0 0001933414 Mineralys Therapeutics, Inc. MLYS 0001672659 Rodman David Malcom false 150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087 0 1 0 0 Chief Medical Officer 1 Common Stock 2026-07-13 4 M 0 3542 10.20 A 61275 D Common Stock 2026-07-13 4 M 0 4167 14.25 A 65442 D Common Stock 2026-07-13 4 M 0 6349 1.08 A 71791 D Common Stock 2026-07-13 4 S 0 14058 27.5798 D 57733 D Common Stock 2026-07-15 4 S 0 6349 26.6112 D 51384 D Stock Option 10.20 2026-07-13 4 M 0 3542 0 D 2035-02-13 Common Stock 3542 109792 D Stock Option 14.25 2026-07-13 4 M 0 4167 0 D 2034-02-13 Common Stock 4167 79167 D Stock Option 1.08 2026-07-13 4 M 0 6349 0 D 2032-07-11 Common Stock 6349 0 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted on October 6, 2025. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $26.965 to $27.750. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $26.41 to $27.15. The Reporting Person undertakes to provide to the Issuer, any securityholder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (3) to this Form 4. The stock option vests in monthly installments over a period of four years, with 1/48th of the total shares underlying the option vesting each one-month period following the date of grant. The stock option vested as to 25% of the underlying shares on the first anniversary of the grant date, with the remaining shares vesting in 36 substantially equal monthly installments thereafter. /s/ Adam Levy, Attorney-in-fact 2026-07-15