<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-06-12-05:00</periodOfReport>

    <notSubjectToSection16>true</notSubjectToSection16>

    <issuer>
        <issuerCik>0002032950</issuerCik>
        <issuerName>Horizon Space Acquisition II Corp.</issuerName>
        <issuerTradingSymbol>HSPT</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001914823</rptOwnerCik>
            <rptOwnerName>Li Mingyu</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>C/O HORIZON SPACE ACQUISITION II CORP.</rptOwnerStreet1>
            <rptOwnerStreet2>1412 BROADWAY, 21ST FLOOR, SUITE 21V</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10018</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>false</aff10b5One>

    <nonDerivativeTable></nonDerivativeTable>

    <remarks>Horizon Space Acquisition II Sponsor Corp. (the &quot;Sponsor&quot;) was the record holder of certain securities of Horizon Space Acquisition II Corp. (&quot;HSPT&quot;). Mr. Mingyu Li beneficially owns 50% issued and outstanding shares of the Sponsor. In accordance with the governing documents of the Sponsor, Mr. Mingyu Li is the sole director of the Sponsor and deemed to have the voting and dispositive rights over the securities of HSPT held by the Sponsor.

This &quot;Exit&quot; Form 4 is voluntarily filed to report that, in connection with the consummation of the initial business combination of HSPT on June 12, 2026 pursuant to the Business Combination Agreement dated May 9, 2025 by and among HSPT, SL Science Holding Limited, a Cayman Islands exempted company limited by shares, SL BIO Ltd., a Cayman Islands exempted company limited by shares, CW Mega Limited, a Cayman Islands exempted company limited by shares, and WW Century Limited, a Cayman Islands exempted company limited by shares, (i) the Reporting Person no longer served as a director or officer of HSPT or held more than 10% of the issued and outstanding ordinary shares of HSPT after June 12, 2026, and therefore is no longer subject to Section 16 reporting, and (ii) the Sponsor no longer held more than 10% of the issued and outstanding ordinary shares of HSPT after June 12, 2026, and therefore is no longer subject to Section 16 reporting.</remarks>

    <ownerSignature>
        <signatureName>/s/ Mingyu Li</signatureName>
        <signatureDate>2026-06-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
